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{{Thin basement membrane disease}}
{{Thin basement membrane disease}}
{{CMG}}
{{CMG}}
{{AE}} {{MMT}}
==Overview==
Obtaining complete [[History and Physical examination|history]] both for the patient and family is an important aspect of diagnosing [[TBMD]]. The hallmark of TBMD is [[Benign Recurrent Hamaturia|benign hematuria.]] A positive [[Family history|family histor]]<nowiki/>y of incidental finding of intermittent or [[Hematuria|persistent hematuria]] is suggestive of [[TBMD]]. TBMD is mostly asymptomatic. [[Microscopic hematuria]] is found incidentally.
==History and Symptoms==
===History===
Obtaining complete [[medical]] and [[family history]] is an important aspect of diagnosing TBMD. It provides insight to cause and differentiation of [[TBMD]] with [[Alport syndrome]], [[IgA nephropathy]], [[Lupus]] [[Nephritis]] and other [[Glomerulopathy|glomerulopathies.]] History may be obtained focusing specific areas including:
*Past [[medical history]] including [[Upper respiratory infection|URTI]], [[Autoimmune disease|Autoimmune Disease]], [[Glomerulopathy|Glomerulopathi]]<nowiki/>es.
*Positive [[family history]] o[[Benign Recurrent Hamaturia|f benign intermittent or persistent hematuria.]]
*[[Physical properties]] of [[urine]] ([[color]], [[turbidity]]).
*Nature of [[micturation]] ([[frequency]], [[dysuria]])
*New onset [[hypertension]] or [[edema]].
===Symptoms===
TBMD is mostly asymptomatic. The following signs are included:


==Overview==
*[[Benign Recurrent Hamaturia|Intermiitent or persistent hematuria]] is found incidentally.
*New onset [[hypertension]].
*[[Proteinuria]].
*[[Renal impairment]].
*[[Renal failure]].


==Biopsy==
A [[needle aspiration biopsy|kidney biopsy]] is the only way to diagnose thin basement membrane disease. It reveals thinning of the [[glomerular basement membrane]] from the normal 300 to 400 nanometers (nm) to 150 to 250&nbsp;nm. However, a [[needle aspiration biopsy|biopsy]] is rarely done in cases where the patient has isolated [[microscopic hematuria]], normal [[kidney function]], and no [[proteinuria]]. The prognosis is excellent in this setting unless the clinical manifestations progress, as occurs in most males and some females with [[Alport syndrome]] and many patients with [[IgA nephropathy]].


==References==
==References==

Latest revision as of 09:37, 21 December 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Marufa Marium, M.B.B.S[2]

Overview

Obtaining complete history both for the patient and family is an important aspect of diagnosing TBMD. The hallmark of TBMD is benign hematuria. A positive family history of incidental finding of intermittent or persistent hematuria is suggestive of TBMD. TBMD is mostly asymptomatic. Microscopic hematuria is found incidentally.

History and Symptoms

History

Obtaining complete medical and family history is an important aspect of diagnosing TBMD. It provides insight to cause and differentiation of TBMD with Alport syndrome, IgA nephropathy, Lupus Nephritis and other glomerulopathies. History may be obtained focusing specific areas including:

Symptoms

TBMD is mostly asymptomatic. The following signs are included:


References

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