Alport syndrome natural history, complications and prognosis: Difference between revisions
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==Natural History== | |||
Recognition of Alport’s syndrome based on the clinical presentation and distinguishing it from other causes of hematuria or extra renal manifestations is important because Alport’s syndrome usually carries a poor prognosis with inevitable progression to end-stage renal disease (ESRD).<ref name="pmid23349312">{{cite journal| author=Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F| title=Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy. | journal=J Am Soc Nephrol | year= 2013 | volume= 24 | issue= 3 | pages= 364-75 | pmid=23349312 | doi=10.1681/ASN.2012020148 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23349312 }} </ref> | |||
==Complications== | |||
*[[Chronic kidney disease]] | |||
*[[End stage renal failure]] | |||
*[[Deafness]] | |||
*Decrease or [[vision loss]] | |||
==Prognosis== | |||
Onset of symptoms often starts during infancy in X-linked Alport’s syndrome; patients reach end-stage renal disease (ESRD) during adolescence.<ref name="pmid23349312">{{cite journal| author=Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F|title=Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy.|journal=J Am Soc Nephrol | year= 2013 | volume= 24 | issue= 3 | pages= 364-75 | pmid=23349312|doi=10.1681/ASN.2012020148 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23349312 }} </ref> All patients with Alport's syndrome eventually progress to ESRD. | |||
Patients with autosomal recessive Alport’s syndrome sometimes progress less rapidly. Although they may still progress to ESRD early, they may reach ESRD during adult life.<ref name="pmid23349312">{{cite journal| author=Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F|title=Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy. |journal=J Am Soc Nephrol | year= 2013 | volume= 24 | issue= 3 | pages= 364-75 | pmid=23349312 |doi=10.1681/ASN.2012020148 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23349312 }} </ref> | |||
==References== | ==References== |
Latest revision as of 20:08, 31 October 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Natural History
Recognition of Alport’s syndrome based on the clinical presentation and distinguishing it from other causes of hematuria or extra renal manifestations is important because Alport’s syndrome usually carries a poor prognosis with inevitable progression to end-stage renal disease (ESRD).[1]
Complications
Prognosis
Onset of symptoms often starts during infancy in X-linked Alport’s syndrome; patients reach end-stage renal disease (ESRD) during adolescence.[1] All patients with Alport's syndrome eventually progress to ESRD.
Patients with autosomal recessive Alport’s syndrome sometimes progress less rapidly. Although they may still progress to ESRD early, they may reach ESRD during adult life.[1]
References
- ↑ 1.0 1.1 1.2 Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F (2013). "Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy". J Am Soc Nephrol. 24 (3): 364–75. doi:10.1681/ASN.2012020148. PMID 23349312.