Brugada syndrome epidemiology and demographics: Difference between revisions
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{{Brugada syndrome}} | {{Brugada syndrome}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
Insofar as Brugada syndrome is a relatively newly recognized syndrome, its [[incidence]] and [[prevalence]] continues to increase. Brugada syndrome is quite common in Southeast Asia where it is [[endemic]], and affects 500 out of every 100,000 individuals. It is the second leading cause of death after car accidents among young people in these countries. It has been estimated that Brugada syndrome accounts for 4% of all sudden cardiac deaths and 20% of [[sudden cardiac death]]s among patients with structurally normal hearts. It is 8-10 times more common in men. | |||
==Epidemiology and Demographics== | |||
===Prevalence=== | |||
* The prevalence of the Brugada syndrome is estimated at 50:100,000, largely depending on geographic location.<ref>{{Cite journal | |||
| author = [[Wasawat Vutthikraivit]], [[Pattara Rattanawong]], [[Prapaipan Putthapiban]], [[Weera Sukhumthammarat]], [[Prin Vathesatogkit]], [[Tachapong Ngarmukos]] & [[Ammarin Thakkinstian]] | |||
| title = Worldwide Prevalence of Brugada Syndrome: A Systematic Review and Meta-Analysis | |||
| journal = [[Acta Cardiologica Sinica]] | |||
| volume = 34 | |||
| issue = 3 | |||
| pages = 267–277 | |||
| year = 2018 | |||
| month = May | |||
| doi = 10.6515/ACS.201805_34(3).20180302B | |||
| pmid = 29844648 | |||
}}</ref> | |||
===Age=== | |||
== | *The incidence of Brugada syndrome increases with age; the median age at diagnosis is 43 years.<ref name="MilmanAndorin2017">{{cite journal|last1=Milman|first1=Anat|last2=Andorin|first2=Antoine|last3=Gourraud|first3=Jean-Baptiste|last4=Sacher|first4=Frederic|last5=Mabo|first5=Philippe|last6=Kim|first6=Sung-Hwan|last7=Maeda|first7=Shingo|last8=Takahashi|first8=Yoshihide|last9=Kamakura|first9=Tsukasa|last10=Aiba|first10=Takeshi|last11=Conte|first11=Giulio|last12=Juang|first12=Jimmy J.M.|last13=Leshem|first13=Eran|last14=Rahkovich|first14=Michael|last15=Hochstadt|first15=Aviram|last16=Mizusawa|first16=Yuka|last17=Postema|first17=Pieter G.|last18=Arbelo|first18=Elena|last19=Huang|first19=Zhengrong|last20=Denjoy|first20=Isabelle|last21=Giustetto|first21=Carla|last22=Wijeyeratne|first22=Yanushi D.|last23=Napolitano|first23=Carlo|last24=Michowitz|first24=Yoav|last25=Brugada|first25=Ramon|last26=Casado-Arroyo|first26=Ruben|last27=Champagne|first27=Jean|last28=Calo|first28=Leonardo|last29=Sarquella-Brugada|first29=Georgia|last30=Tfelt-Hansen|first30=Jacob|last31=Priori|first31=Silvia G.|last32=Takagi|first32=Masahiko|last33=Veltmann|first33=Christian|last34=Delise|first34=Pietro|last35=Corrado|first35=Domenico|last36=Behr|first36=Elijah R.|last37=Gaita|first37=Fiorenzo|last38=Yan|first38=Gan-Xin|last39=Brugada|first39=Josep|last40=Leenhardt|first40=Antoine|last41=Wilde|first41=Arthur A.M.|last42=Brugada|first42=Pedro|last43=Kusano|first43=Kengo F.|last44=Hirao|first44=Kenzo|last45=Nam|first45=Gi-Byoung|last46=Probst|first46=Vincent|last47=Belhassen|first47=Bernard|title=Age of First Arrhythmic Event in Brugada Syndrome|journal=Circulation: Arrhythmia and Electrophysiology|volume=10|issue=12|year=2017|issn=1941-3149|doi=10.1161/CIRCEP.117.005222}}</ref><ref name="BrugadaSieira2016">{{cite journal|last1=Brugada|first1=Pedro|last2=Sieira|first2=Juan|title=Brugada Syndrome: Defining the Risk in Asymptomatic Patients|journal=Arrhythmia & Electrophysiology Review|volume=5|issue=3|year=2016|pages=164|issn=2050-3369|doi=10.15420/aer.2016:22:3}}</ref> | ||
The | *The average age at the time of initial diagnosis or sudden death is 40 ± 22 years, with the youngest patient diagnosed at 2 days of age and the oldest at 84 years. Brugada syndrome usually becomes apparent in adulthood, although signs and symptoms, including sudden death, can occur any time from early infancy to old age. The mean age of sudden death is approximately 40 years. This condition may explain some cases of sudden infant death syndrome ([[SIDS]]), which is a major cause of death in babies younger than one year. It is characterized by sudden and unexplained death, usually during sleep. Sudden unexplained nocturnal death syndrome (SUNDS) is a condition characterized by unexpected [[cardiac arrest]] in young adults, usually at night during sleep. This condition was originally described in Southeast Asian populations, where it is a major cause of death. Researchers have determined that SUNDS and Brugada syndrome are the same disorder.<ref>{{Cite journal | ||
| author = [[Charles Antzelevitch]] | |||
| title = Brugada syndrome | |||
| journal = [[Pacing and clinical electrophysiology : PACE]] | |||
| volume = 29 | |||
| issue = 10 | |||
| pages = 1130–1159 | |||
| year = 2006 | |||
| month = October | |||
| doi = 10.1111/j.1540-8159.2006.00507.x | |||
| pmid = 17038146 | |||
}}</ref> | |||
== | ===Race=== | ||
*Brugada syndrome usually affects individuals of Asian ancestry, particularly in Japanese and Southeast Asian populations.<ref>Brugada J, Brugada P, Brugada R. The syndrome of right bundle branch block ST segment elevation in V1 to V3 and sudden death--the Brugada syndrome. Europace. 1999 Jul;1(3):156-66. PMID 11225790 </ref> | |||
*Brugada syndrome is the most common cause of sudden death in young men without known underlying cardiac disease in Thailand and Laos. | |||
*Among different Asian countries, different names have been given to SUDS: in the Phillipines it is called ''bangungut'' (to rise and moan in sleep) and in Thailand ''lai tai'' (death during sleep).<ref name="AntzelevitchBrugada2005">{{cite journal|last1=Antzelevitch|first1=Charles|last2=Brugada|first2=Pedro|last3=Borggrefe|first3=Martin|last4=Brugada|first4=Josep|last5=Brugada|first5=Ramon|last6=Corrado|first6=Domenico|last7=Gussak|first7=Ihor|last8=LeMarec|first8=Herve|last9=Nademanee|first9=Koonlawee|last10=Perez Riera|first10=Andres Ricardo|last11=Shimizu|first11=Wataru|last12=Schulze-Bahr|first12=Eric|last13=Tan|first13=Hanno|last14=Wilde|first14=Arthur|title=Brugada Syndrome: Report of the Second Consensus Conference|journal=Circulation|volume=111|issue=5|year=2005|pages=659–670|issn=0009-7322|doi=10.1161/01.CIR.0000152479.54298.51}}</ref> | |||
==Gender== | ===Gender=== | ||
*Brugada syndrome affects [[men]] and [[women]].<ref>{{Cite journal | |||
| author = [[Carlo Pappone]] & [[Vincenzo Santinelli]] | |||
| title = Brugada Syndrome: Progress in Diagnosis and Management | |||
| journal = [[Arrhythmia & electrophysiology review]] | |||
| volume = 8 | |||
| issue = 1 | |||
| pages = 13–18 | |||
| year = 2019 | |||
| month = March | |||
| doi = 10.15420/aer.2018.73.2 | |||
| pmid = 30918662 | |||
}}</ref> | |||
*[[Men]] are more commonly affected by Brugada syndrome than [[women]]. The [[men]] to [[women]] ratio is approximately 8 to 10 .<ref name="YuanTian2018">{{cite journal|last1=Yuan|first1=Mengchen|last2=Tian|first2=Chao|last3=Li|first3=Xinye|last4=Yang|first4=Xinyu|last5=Wang|first5=Xiaofeng|last6=Yang|first6=Yihan|last7=Liu|first7=Nian|last8=Kusano|first8=Kengo F.|last9=Barajas-Martinez|first9=Hector|last10=Hu|first10=Dan|last11=Shang|first11=Hongcai|last12=Gao|first12=Yonghong|last13=Xing|first13=Yanwei|title=Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials|journal=Frontiers in Physiology|volume=9|year=2018|issn=1664-042X|doi=10.3389/fphys.2018.01127}}</ref> | |||
==References== | ==References== | ||
{{ | {{Reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[CME Category::Cardiology]] | |||
[[Category:Electrophysiology]] | |||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
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[[Category:Genetic disorders]] | |||
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Latest revision as of 19:07, 16 December 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Insofar as Brugada syndrome is a relatively newly recognized syndrome, its incidence and prevalence continues to increase. Brugada syndrome is quite common in Southeast Asia where it is endemic, and affects 500 out of every 100,000 individuals. It is the second leading cause of death after car accidents among young people in these countries. It has been estimated that Brugada syndrome accounts for 4% of all sudden cardiac deaths and 20% of sudden cardiac deaths among patients with structurally normal hearts. It is 8-10 times more common in men.
Epidemiology and Demographics
Prevalence
- The prevalence of the Brugada syndrome is estimated at 50:100,000, largely depending on geographic location.[1]
Age
- The incidence of Brugada syndrome increases with age; the median age at diagnosis is 43 years.[2][3]
- The average age at the time of initial diagnosis or sudden death is 40 ± 22 years, with the youngest patient diagnosed at 2 days of age and the oldest at 84 years. Brugada syndrome usually becomes apparent in adulthood, although signs and symptoms, including sudden death, can occur any time from early infancy to old age. The mean age of sudden death is approximately 40 years. This condition may explain some cases of sudden infant death syndrome (SIDS), which is a major cause of death in babies younger than one year. It is characterized by sudden and unexplained death, usually during sleep. Sudden unexplained nocturnal death syndrome (SUNDS) is a condition characterized by unexpected cardiac arrest in young adults, usually at night during sleep. This condition was originally described in Southeast Asian populations, where it is a major cause of death. Researchers have determined that SUNDS and Brugada syndrome are the same disorder.[4]
Race
- Brugada syndrome usually affects individuals of Asian ancestry, particularly in Japanese and Southeast Asian populations.[5]
- Brugada syndrome is the most common cause of sudden death in young men without known underlying cardiac disease in Thailand and Laos.
- Among different Asian countries, different names have been given to SUDS: in the Phillipines it is called bangungut (to rise and moan in sleep) and in Thailand lai tai (death during sleep).[6]
Gender
- Brugada syndrome affects men and women.[7]
- Men are more commonly affected by Brugada syndrome than women. The men to women ratio is approximately 8 to 10 .[8]
References
- ↑ Wasawat Vutthikraivit, Pattara Rattanawong, Prapaipan Putthapiban, Weera Sukhumthammarat, Prin Vathesatogkit, Tachapong Ngarmukos & Ammarin Thakkinstian (2018). "Worldwide Prevalence of Brugada Syndrome: A Systematic Review and Meta-Analysis". Acta Cardiologica Sinica. 34 (3): 267–277. doi:10.6515/ACS.201805_34(3).20180302B. PMID 29844648. Unknown parameter
|month=ignored (help) - ↑ Milman, Anat; Andorin, Antoine; Gourraud, Jean-Baptiste; Sacher, Frederic; Mabo, Philippe; Kim, Sung-Hwan; Maeda, Shingo; Takahashi, Yoshihide; Kamakura, Tsukasa; Aiba, Takeshi; Conte, Giulio; Juang, Jimmy J.M.; Leshem, Eran; Rahkovich, Michael; Hochstadt, Aviram; Mizusawa, Yuka; Postema, Pieter G.; Arbelo, Elena; Huang, Zhengrong; Denjoy, Isabelle; Giustetto, Carla; Wijeyeratne, Yanushi D.; Napolitano, Carlo; Michowitz, Yoav; Brugada, Ramon; Casado-Arroyo, Ruben; Champagne, Jean; Calo, Leonardo; Sarquella-Brugada, Georgia; Tfelt-Hansen, Jacob; Priori, Silvia G.; Takagi, Masahiko; Veltmann, Christian; Delise, Pietro; Corrado, Domenico; Behr, Elijah R.; Gaita, Fiorenzo; Yan, Gan-Xin; Brugada, Josep; Leenhardt, Antoine; Wilde, Arthur A.M.; Brugada, Pedro; Kusano, Kengo F.; Hirao, Kenzo; Nam, Gi-Byoung; Probst, Vincent; Belhassen, Bernard (2017). "Age of First Arrhythmic Event in Brugada Syndrome". Circulation: Arrhythmia and Electrophysiology. 10 (12). doi:10.1161/CIRCEP.117.005222. ISSN 1941-3149.
- ↑ Brugada, Pedro; Sieira, Juan (2016). "Brugada Syndrome: Defining the Risk in Asymptomatic Patients". Arrhythmia & Electrophysiology Review. 5 (3): 164. doi:10.15420/aer.2016:22:3. ISSN 2050-3369.
- ↑ Charles Antzelevitch (2006). "Brugada syndrome". Pacing and clinical electrophysiology : PACE. 29 (10): 1130–1159. doi:10.1111/j.1540-8159.2006.00507.x. PMID 17038146. Unknown parameter
|month=ignored (help) - ↑ Brugada J, Brugada P, Brugada R. The syndrome of right bundle branch block ST segment elevation in V1 to V3 and sudden death--the Brugada syndrome. Europace. 1999 Jul;1(3):156-66. PMID 11225790
- ↑ Antzelevitch, Charles; Brugada, Pedro; Borggrefe, Martin; Brugada, Josep; Brugada, Ramon; Corrado, Domenico; Gussak, Ihor; LeMarec, Herve; Nademanee, Koonlawee; Perez Riera, Andres Ricardo; Shimizu, Wataru; Schulze-Bahr, Eric; Tan, Hanno; Wilde, Arthur (2005). "Brugada Syndrome: Report of the Second Consensus Conference". Circulation. 111 (5): 659–670. doi:10.1161/01.CIR.0000152479.54298.51. ISSN 0009-7322.
- ↑ Carlo Pappone & Vincenzo Santinelli (2019). "Brugada Syndrome: Progress in Diagnosis and Management". Arrhythmia & electrophysiology review. 8 (1): 13–18. doi:10.15420/aer.2018.73.2. PMID 30918662. Unknown parameter
|month=ignored (help) - ↑ Yuan, Mengchen; Tian, Chao; Li, Xinye; Yang, Xinyu; Wang, Xiaofeng; Yang, Yihan; Liu, Nian; Kusano, Kengo F.; Barajas-Martinez, Hector; Hu, Dan; Shang, Hongcai; Gao, Yonghong; Xing, Yanwei (2018). "Gender Differences in Prognosis and Risk Stratification of Brugada Syndrome: A Pooled Analysis of 4,140 Patients From 24 Clinical Trials". Frontiers in Physiology. 9. doi:10.3389/fphys.2018.01127. ISSN 1664-042X.