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==Overview==
==Medical Therapy==
==Medical Therapy==
The distribution of these agents in their natural reservoirs will eventually define the geographic range of the threat the viruses pose. However, these viruses are recent discoveries, and much work remains to be done on their geographic distribution and the reservoir species. The occurrence of the disease in humans has been associated only with infection of an intermediate species such as horses with Hendra and swine with Nipah virus. Early recognition of the disease in the intermediate animal host is probably the most crucial means of limiting future human cases.
The distribution of these agents in their natural reservoirs will eventually define the geographic range of the threat the viruses pose. However, these viruses are recent discoveries, and much work remains to be done on their geographic distribution and the reservoir species. The occurrence of the disease in humans has been associated only with infection of an intermediate species such as horses with Hendra and swine with Nipah virus. Early recognition of the disease in the intermediate animal host is probably the most crucial means of limiting future human cases.


=== Pharmacotherapy ===
There have been many open label trials in which Ribavarin was found to reduce the [[mortality]] of acute Nipah virus [[encephalitis]] without any serious adverse effects<ref name="pmid11409437">{{cite journal| author=Chong HT, Kamarulzaman A, Tan CT, Goh KJ, Thayaparan T, Kunjapan SR et al.| title=Treatment of acute Nipah encephalitis with ribavirin. | journal=Ann Neurol | year= 2001 | volume= 49 | issue= 6 | pages= 810-3 | pmid=11409437 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11409437  }} </ref><ref name="pmid18582201">{{cite journal| author=Tunkel AR, Glaser CA, Bloch KC, Sejvar JJ, Marra CM, Roos KL et al.| title=The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America. | journal=Clin Infect Dis | year= 2008 | volume= 47 | issue= 3 | pages= 303-27 | pmid=18582201 | doi=10.1086/589747 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18582201  }} </ref>. However, more data is required in recommending its use.
The drug [[ribavirin]] has been shown to be effective against the viruses in vitro. However, controlled drug investigations have not been performed and the clinical usefulness of these drugs is uncertain.
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Infectious disease]]
 
[[Category:Mature chapter]]
[[Category:Mature chapter]]
[[Category:Needs overview]]
[[Category:Needs overview]]
[[Category:Viral diseases]]

Latest revision as of 18:11, 18 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Medical Therapy

The distribution of these agents in their natural reservoirs will eventually define the geographic range of the threat the viruses pose. However, these viruses are recent discoveries, and much work remains to be done on their geographic distribution and the reservoir species. The occurrence of the disease in humans has been associated only with infection of an intermediate species such as horses with Hendra and swine with Nipah virus. Early recognition of the disease in the intermediate animal host is probably the most crucial means of limiting future human cases.

There have been many open label trials in which Ribavarin was found to reduce the mortality of acute Nipah virus encephalitis without any serious adverse effects[1][2]. However, more data is required in recommending its use.

References

  1. Chong HT, Kamarulzaman A, Tan CT, Goh KJ, Thayaparan T, Kunjapan SR; et al. (2001). "Treatment of acute Nipah encephalitis with ribavirin". Ann Neurol. 49 (6): 810–3. PMID 11409437.
  2. Tunkel AR, Glaser CA, Bloch KC, Sejvar JJ, Marra CM, Roos KL; et al. (2008). "The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America". Clin Infect Dis. 47 (3): 303–27. doi:10.1086/589747. PMID 18582201.

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