Malabsorption causes: Difference between revisions

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{{Malabsorption}}
{{Malabsorption}}
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{{CMG}} {{AE}} {{Maheep}} {{LRO}}


==Causes==
==Overview==
Malabsorption syndrome is commonly caused by [[gastroenterological]] conditions, including [[bacterial]] infections and other sources of [[liver]], [[intestine]], and [[pancreatic]] [[inflammation]]. It is also commonly caused by sources of [[anemia]].


===Due to Infective Agents===
==Causes<ref>{{cite book |author=M. S Losowsky, |title=Malabsorption in clinical practice |publisher=Churchill Livingstone |location=Edinburgh |year= |pages= |isbn=0-443-01007-2 |oclc= |doi=}}</ref>==
*[[Whipple's disease]]
<div style="-webkit-user-select: none;">
*Intestinal [[tuberculosis]]
===Life Threatening Causes===
*[[HIV]] related malabsorption
*[[Aids]]
*[[Tropical sprue]]
*[[Atrophic gastritis ]]
*[[Traveller's diarrhoea]]
*[[Bacterial overgrowth]]
*[[Parasites]] e.g. [[giardiasis|''Giardia lamblia'']], [[Diphyllobothrium|fish tape worm]] (B12 malabsorption), [[Strongyloides stercoralis|round warm]], [[hookworm]] (''Ancylostoma duodenale'' and ''Necator americanus'').
*[[Carcinoid syndrome]]
*[[Carcinoma of pancreas]]
*[[Chronic pancreatitis]]
*[[Cirrhosis]]
*[[Cystic fibrosis]]
*[[Hiv related malabsorption]]
*[[Ileal disease ]]
*[[Intestinal lymphoma]]
*[[Intestinal trauma]]
*[[Intestinal tuberculosis]]
*[[Liver disease]]
*[[Lymphoma ]]
*[[Mastocytosis]]
*[[Pancreatic insufficiencies]]
*[[Pancreatitis]]
*[[Terminal ileal disease]]


===Due to Structural Defects<ref>{{cite book |author=M. S Losowsky, |title=Malabsorption in clinical practice |publisher=Churchill Livingstone |location=Edinburgh |year= |pages= |isbn=0-443-01007-2 |oclc= |doi=}}</ref>===
===Common Causes===  
*[[blind loop syndrome|Blind loops]]
*[[Atrophic gastritis]]
*Inflammatory bowel diseases commonly in [[Crohn's Disease]]
*[[B12 malabsorption]]  
*Intestinal hurry from Post-[[gastrectomy]]; post-[[vagotomy]], gastro-jejunostomy
*[[Fistulae]], [[Diverticulum|diverticulae]] and [[strictures]],
*Infiltrative conditions such as [[amyloidosis]], [[lymphoma]], Eosinophilic gastroenteropathy
*[[Radiation enteritis]]
*[[Systemic sclerosis]] and collagen vascular diseases
 
===Due to Mucosal Abnormality===
*[[Celiac disease]]
*[[Celiac disease]]
*Cows' milk intolerance
*[[Celiac sprue]]
*Soya milk intolerance
*[[Cholestasis]]
 
*[[Chronic pancreatitis]]
===Due to Enzyme Defeciencies===
*[[Cirrhosis]]
*Lactase deficiency inducing [[lactose intolerance]] (constitutional, secondary or rarely congenital)
*[[Crohn's disease]]
*[[Sucrose intolerance]]  
*[[Disaccharidase deficiency]] 
*Intestinal disaccharidase defeciency
*[[Gallbladder disease]]
*Intestinal enteropeptidase defeciency
*[[Giardia lamblia]]
*[[Giardiasis]]
*[[Hiv related malabsorption]]
*[[Intestinal radiation therapy]]
*[[Intestinal surgery]]
*[[Intestinal trauma]]
*[[Intestinal tuberculosis]]
*[[Lactase deficiency ]],
*[[Laxative abuse]],
*[[Liver disease]],
*[[Menetrier disease]],
*[[Obstructive jaundice]],
*[[Pancreatic insufficiencies]],
*[[Pancreatitis]],
*[[Postgastrectomy syndrome]],
*[[Short bowel syndrome]],
*[[Short gut syndrome]],  
*[[Soya milk intolerance]],
*[[Ulcerative colitis]],
*[[Whipple's disease]],


===Due to Digestive Failure===
===Causes by Organ System===
*Pancreatic insuffeciencies:
{|style="width:80%; height:100px" border="1"
**[[Cystic fibrosis]]
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
**[[Chronic pancreatitis]]
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" |  [[Abetalipoproteinemia]],  [[Anderson disease]],  [[Apolipoprotein b deficiency]],  [[Cholesterol ester storage disease]],  [[Strictures]],  [[Systemic sclerosis ]]
**[[Carcinoma of pancreas]]
|-
**[[Zollinger-Ellison syndrome]]
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
*[[Bile salt]] malabsorption
|bgcolor="Beige"| No underlying causes
**Terminal ileal disease
|-
**[[Obstructive jaundice]]
|-bgcolor="LightSteelBlue"
**[[Bacterial overgrowth]]
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| [[Cholestatic jaundice]],  [[Collagen vascular diseases]]
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Colchicine]],  [[Colestyramine]],  [[Efavirenz]],  [[Laxative abuse]],  [[Metformin]],  [[Neomycin]],  [[Prolonged antibiotic use]]
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| [[Addison's disease]],  [[Autoimmune polyendocrine syndrome type 1]],  [[Hyperparathyroidism ]],  [[Hyperthyroidism]],  [[Hypoparathyroidism]],  [[Hypothyroidism ]]
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Alagille syndrome]],  [[Atrophic gastritis ]],  [[B12 malabsorption]],  [[Bile acid malabsorption syndrome]],  [[Bile salt malabsorption]],  [[Biliary atresia]],  [[Blind loops]],  [[Canada-cronkhite syndrome]],  [[Carcinoma of pancreas]],  [[Celiac disease]],  [[Celiac sprue]],  [[Cholestasis]],  [[Cholestatic jaundice]],  [[Chronic cholestasis]],  [[Chronic granulomatous disease]],  [[Chronic pancreatitis]],  [[Chylomicron retention disease]],  [[Cirrhosis]],  [[Cow's milk intolerance]],  [[Crohn's disease]],  [[Disaccharidase deficiency]],  [[Diverticulae]],  [[Eosinophilic gastroenteropathy]],  [[Fistulae]],  [[Gallbladder disease]],  [[Giardia lamblia]],  [[Giardiasis]],  [[Graft versus host disease]],  [[Hiv related malabsorption]],  [[Ileal disease ]],  [[Intestinal disaccharidase deficiency]],  [[Intestinal enteropeptidase deficiency]],  [[Intestinal lymphangiectasia]],  [[Intestinal lymphoma]],  [[Intestinal radiation therapy]],  [[Intestinal surgery]],  [[Intestinal trauma]],  [[Intestinal tuberculosis]],  [[Lactase deficiency ]],  [[Laxative abuse]],  [[Liver disease]],  [[Menetrier disease]],  [[Obstructive jaundice]],  [[Pancreatic insufficiencies]],  [[Pancreatitis]],  [[Pearson marrow-pancreas syndrome]],  [[Post billroth ii procedure]],  [[Postgastrectomy syndrome]],  [[Radiation enteritis]],  [[Short bowel syndrome]],  [[Short gut syndrome]],  [[Shwachman-diamond syndrome]],  [[Soya milk intolerance]],  [[Terminal ileal disease]],  [[Trichohepatoenteric syndrome 1]],  [[Tropical sprue]],  [[Ulcerative colitis]],  [[Whipple's disease]],  [[Zollinger-ellison syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| [[Alagille syndrome]],  [[Canada-cronkhite syndrome]],  [[Disaccharidase deficiency]],  [[Hartnup's disease]],  [[Johanson-blizzard syndrome]],  [[Trypsinogen deficiency]]
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| [[3-beta-hydroxy-delta-5-c27-steroid oxidoreductase deficiency]],  [[Abetalipoproteinemia]],  [[Apolipoprotein b deficiency]],  [[B12 malabsorption]],  [[Common variable hypogammaglobulinaemia]],  [[Diabetes mellitus]],  [[Eosinophilic gastroenteropathy]],  [[Hypogammaglobulinaemia]],  [[Ileal disease ]],  [[Obstructive jaundice]],  [[Pernicious anemia ]],  [[Shwachman-diamond syndrome]],  [[Small bowel lymphoma]],  [[Sucrase-isomaltase deficiency]],  [[Sucrose intolerance]],  [[Terminal ileal disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| [[Intestinal radiation therapy]],  [[Intestinal surgery]],  [[Post billroth ii procedure]],  [[Postgastrectomy syndrome]],  [[Radiation enteritis]]
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| [[Aids]],  [[Bacterial overgrowth]],  [[Blind loops]],  [[Fasciolopsis buski]],  [[Fish tape worm]],  [[Giardia lamblia]],  [[Giardiasis]],  [[Hiv related malabsorption]],  [[Hookworm]],  [[Intestinal tuberculosis]],  [[Pancreatitis]],  [[Strongyloidiasis]],  [[Whipple's disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| [[Diabetes mellitus]],  [[Malnutrition]]
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| [[Carcinoid syndrome]],  [[Carcinoma of pancreas]],  [[Intestinal lymphoma]],  [[Lymphoma ]],  [[Mastocytosis]],  [[Small bowel lymphoma]],  [[Zollinger-ellison syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| [[Gallbladder disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| [[Alpha heavy chain disease]],  [[Amyloidosis]],  [[Celiac disease]],  [[Celiac sprue]],  [[Cow's milk intolerance]],  [[Crohn's disease]],  [[Cystic fibrosis]],  [[Mastocytosis]],  [[Soya milk intolerance]]
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| [[Aids]]
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| [[Intestinal trauma]]
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
|-
|}


===Due to Other [[Systemic Disease]]s Affecting GI Tract===
===Causes in Alphabetical Order===
*[[Hypothyroidism]] and [[hyperthyroidism]]
{{columns-list|
*[[3-beta-hydroxy-delta-5-c27-steroid oxidoreductase deficiency]]
*[[Abetalipoproteinemia]]
*[[Addison's disease]]
*[[Addison's disease]]
*[[Aids]]
*[[Alagille syndrome]]
*[[Alpha heavy chain disease]]
*[[Amyloidosis]]
*[[Anderson disease]]
*[[Apolipoprotein b deficiency]]
*[[Atrophic gastritis ]]
*[[Autoimmune polyendocrine syndrome type 1]]
*[[B12 malabsorption]]
*[[Bacterial overgrowth]]
*[[Bile acid malabsorption syndrome]]
*[[Bile salt malabsorption]]
*[[Biliary atresia]]
*[[Blind loops]]
*[[Canada-cronkhite syndrome]]
*[[Carcinoid syndrome]]
*[[Carcinoma of pancreas]]
*[[Celiac disease]]
*[[Celiac sprue]]
*[[Cholestasis]]
*[[Cholestatic jaundice]]
*[[Cholesterol ester storage disease]]
*[[Chronic cholestasis]]
*[[Chronic granulomatous disease]]
*[[Chronic pancreatitis]]
*[[Chylomicron retention disease]]
*[[Cirrhosis]]
*[[Colchicine]]
*[[Colestyramine]]
*[[Collagen vascular diseases]]
*[[Common variable hypogammaglobulinaemia]]
*[[Cow's milk intolerance]]
*[[Crohn disease]]
*[[Crohn's disease]]
*[[Cystic fibrosis]]
*[[Diabetes mellitus]]
*[[Diabetes mellitus]]
*[[Hyperparathyroidism]] and [[Hypoparathyroidism]]
*[[Disaccharidase deficiency]]
*[[Carcinoid syndrome]]
*[[Diverticulae]]
*Malnutrition
*[[Efavirenz]]
*[[Abetalipoproteinemia|Abeta-lipoproteinemia]]
*[[Eosinophilic gastroenteropathy]]
*[[Fasciolopsis buski]]
*[[Fish tape worm]]
*[[Fistulae]]
*[[Gallbladder disease]]
*[[Giardia lamblia]]
*[[Giardiasis]]
*[[Graft versus host disease]]
*[[Hartnup's disease]]
*[[Hiv related malabsorption]]
*[[Hookworm]]
*[[Hyperparathyroidism ]]
*[[Hyperthyroidism]]
*[[Hypogammaglobulinaemia]]
*[[Hypoparathyroidism]]
*[[Hypothyroidism ]]
*[[Ileal disease ]]
*[[Intestinal disaccharidase deficiency]]
*[[Intestinal enteropeptidase deficiency]]
*[[Intestinal lymphangiectasia]]
*[[Intestinal lymphoma]]
*[[Intestinal radiation therapy]]
*[[Intestinal surgery]]
*[[Intestinal trauma]]
*[[Intestinal tuberculosis]]
*[[Johanson-blizzard syndrome]]
*[[Lactase deficiency ]]
*[[Laxative abuse]]
*[[Liver disease]]
*[[Lymphoma ]]
*[[Malnutrition]]
*[[Mastocytosis]]
*[[Menetrier disease]]
*[[Metformin]]
*[[Neomycin]]
*[[Obstructive jaundice]]
*[[Pancreatic insufficiencies]]
*[[Pancreatitis]]
*[[Pearson marrow-pancreas syndrome]]
*[[Pernicious anemia ]]
*[[Post billroth ii procedure]]
*[[Postgastrectomy syndrome]]
*[[Prolonged antibiotic use]]
*[[Radiation enteritis]]
*[[Short bowel syndrome]]
*[[Short gut syndrome]]
*[[Shwachman-diamond syndrome]]
*[[Small bowel lymphoma]]
*[[Soya milk intolerance]]
*[[Strictures]]
*[[Strongyloidiasis]]
*[[Sucrase-isomaltase deficiency]]
*[[Sucrose intolerance]]
*[[Systemic sclerosis ]]
*[[Terminal ileal disease]]
*[[Traveller's diarrhoea]]
*[[Trichohepatoenteric syndrome 1]]
*[[Tropical sprue]]
*[[Trypsinogen deficiency]]
*[[Ulcerative colitis]]
*[[Whipple's disease]]
*[[Zollinger-ellison syndrome]]
}}
</div>


==References==
==References==
{{Reflist|2}}


{{Reflist|2}}
[[Category:Disease]]
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Needs overview]]
 
[[Category:Needs causes]]
{{WS}}
{{WH}}

Latest revision as of 21:53, 10 January 2020

Malabsorption

Home

Overview

Classification

Infection
Structural defect
Digestive failure
Systemic disease
Iatrogenic

Differentiating Malabsorption from other Diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maheep Sangha, M.B.B.S. Luke Rusowicz-Orazem, B.S.

Overview

Malabsorption syndrome is commonly caused by gastroenterological conditions, including bacterial infections and other sources of liver, intestine, and pancreatic inflammation. It is also commonly caused by sources of anemia.

Causes[1]

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular Abetalipoproteinemia, Anderson disease, Apolipoprotein b deficiency, Cholesterol ester storage disease, Strictures, Systemic sclerosis 
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic Cholestatic jaundice, Collagen vascular diseases
Drug Side Effect Colchicine, Colestyramine, Efavirenz, Laxative abuse, Metformin, Neomycin, Prolonged antibiotic use
Ear Nose Throat No underlying causes
Endocrine Addison's disease, Autoimmune polyendocrine syndrome type 1, Hyperparathyroidism , Hyperthyroidism, Hypoparathyroidism, Hypothyroidism 
Environmental No underlying causes
Gastroenterologic Alagille syndrome, Atrophic gastritis , B12 malabsorption, Bile acid malabsorption syndrome, Bile salt malabsorption, Biliary atresia, Blind loops, Canada-cronkhite syndrome, Carcinoma of pancreas, Celiac disease, Celiac sprue, Cholestasis, Cholestatic jaundice, Chronic cholestasis, Chronic granulomatous disease, Chronic pancreatitis, Chylomicron retention disease, Cirrhosis, Cow's milk intolerance, Crohn's disease, Disaccharidase deficiency, Diverticulae, Eosinophilic gastroenteropathy, Fistulae, Gallbladder disease, Giardia lamblia, Giardiasis, Graft versus host disease, Hiv related malabsorption, Ileal disease , Intestinal disaccharidase deficiency, Intestinal enteropeptidase deficiency, Intestinal lymphangiectasia, Intestinal lymphoma, Intestinal radiation therapy, Intestinal surgery, Intestinal trauma, Intestinal tuberculosis, Lactase deficiency , Laxative abuse, Liver disease, Menetrier disease, Obstructive jaundice, Pancreatic insufficiencies, Pancreatitis, Pearson marrow-pancreas syndrome, Post billroth ii procedure, Postgastrectomy syndrome, Radiation enteritis, Short bowel syndrome, Short gut syndrome, Shwachman-diamond syndrome, Soya milk intolerance, Terminal ileal disease, Trichohepatoenteric syndrome 1, Tropical sprue, Ulcerative colitis, Whipple's disease, Zollinger-ellison syndrome
Genetic Alagille syndrome, Canada-cronkhite syndrome, Disaccharidase deficiency, Hartnup's disease, Johanson-blizzard syndrome, Trypsinogen deficiency
Hematologic 3-beta-hydroxy-delta-5-c27-steroid oxidoreductase deficiency, Abetalipoproteinemia, Apolipoprotein b deficiency, B12 malabsorption, Common variable hypogammaglobulinaemia, Diabetes mellitus, Eosinophilic gastroenteropathy, Hypogammaglobulinaemia, Ileal disease , Obstructive jaundice, Pernicious anemia , Shwachman-diamond syndrome, Small bowel lymphoma, Sucrase-isomaltase deficiency, Sucrose intolerance, Terminal ileal disease
Iatrogenic Intestinal radiation therapy, Intestinal surgery, Post billroth ii procedure, Postgastrectomy syndrome, Radiation enteritis
Infectious Disease Aids, Bacterial overgrowth, Blind loops, Fasciolopsis buski, Fish tape worm, Giardia lamblia, Giardiasis, Hiv related malabsorption, Hookworm, Intestinal tuberculosis, Pancreatitis, Strongyloidiasis, Whipple's disease
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Diabetes mellitus, Malnutrition
Obstetric/Gynecologic No underlying causes
Oncologic Carcinoid syndrome, Carcinoma of pancreas, Intestinal lymphoma, Lymphoma , Mastocytosis, Small bowel lymphoma, Zollinger-ellison syndrome
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Gallbladder disease
Rheumatology/Immunology/Allergy Alpha heavy chain disease, Amyloidosis, Celiac disease, Celiac sprue, Cow's milk intolerance, Crohn's disease, Cystic fibrosis, Mastocytosis, Soya milk intolerance
Sexual Aids
Trauma Intestinal trauma
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

  1. ↑ M. S Losowsky,. Malabsorption in clinical practice. Edinburgh: Churchill Livingstone. ISBN 0-443-01007-2.

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