Amyotrophic lateral sclerosis classification: Difference between revisions

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{{Amyotrophic lateral sclerosis}}
{{Amyotrophic lateral sclerosis}}
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==Overview==
==Overview==
ALS is classified into three general groups, '''familial ALS''', '''sporadic ALS''' and '''Guamanian ALS'''.
ALS is classified into two sub-groups: '''Familial ALS''' and '''Sporadic ALS.'''  
==Classification==
==Classification==
* "Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors.  Of these approximately 10% are linked to a mutation in [[Superoxide dismutase]] (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals.
* Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component.
* A third type, called "Guamanian ALS", represents a small cluster of cases concentrated on the Pacific island of Guam.


==Guamanian ALS==
*'''Familial ALS''' accounts for approximately 5%-10% of all ALS cases and is caused due to genetic factors.
There was a high inicidence of this rare form of ALS from the 1940s to the 1960's, and during this thie, the rates of ALS increased by 50 to 100 times of its incidence prior to this time. The incidence of Guamanian ALS has dropped significantly since the 1960's, but during it's peak, it killed more than 10% of the native Chamorro people of Guam.
*'''Sporadic ALS''' accounts for the remaining 90%-95% of ALS with no known cause.  


===Parkinson's and Alzheimers Association===
<br />
Unique to the Guamanian form of ALS
<ref name="pmid30207670">{{cite journal| author=Hulisz D| title=Amyotrophic lateral sclerosis: disease state overview. | journal=Am J Manag Care | year= 2018 | volume= 24 | issue= 15 Suppl | pages= S320-S326 | pmid=30207670 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30207670  }} </ref>


==References==
==References==

Latest revision as of 11:34, 2 July 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]Mohamadmostafa Jahansouz M.D.[3]

Overview

ALS is classified into two sub-groups: Familial ALS and Sporadic ALS.

Classification

  • Familial ALS accounts for approximately 5%-10% of all ALS cases and is caused due to genetic factors.
  • Sporadic ALS accounts for the remaining 90%-95% of ALS with no known cause.


[1]

References

  1. Hulisz D (2018). "Amyotrophic lateral sclerosis: disease state overview". Am J Manag Care. 24 (15 Suppl): S320–S326. PMID 30207670.

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