Bornholm disease pathophysiology: Difference between revisions
(Created page with "__NOTOC__ {{CMG}} {{Bornholm disease}} ==Overview== Bornholm disease usually is caused by one of the group B coxsackieviruses and is less often caused by a group A coxsackiev...") |
No edit summary |
||
| (23 intermediate revisions by 4 users not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Bornholm disease}} | {{Bornholm disease}} | ||
{{CMG}}; '''Associate Editor(s)-in-Chief:''' [[User:AroojNaz|Arooj Naz, M.B.B.S]] | |||
==Overview== | ==Overview== | ||
Bornholm disease | Bornholm disease is a disease caused by one of the [[Coxsackie B virus|group B coxsackie virus]]es and is less often caused by a [[Coxsackie A virus|group A coxsackie virus]] or an [[echovirus]], causing pain in the muscles of the chest that join ribs together. The virus is spread by contact and epidemics usually occur during warm weather in temperate regions and at any time in the tropics, primarily through [[saliva]] and feces. From within the [[pharynx]], the viruse multiplies in the throat and [[intestines]], the muscles of the [[Chest wall muscles|chest wall]], [[abdominal muscles]] and [[diaphragm]] after which it enters the [[lymphatic tissues]]. The virus uses [[autophagy]] to increase [[viral replication]]. | ||
==Pathophysiology== | ==Pathophysiology== | ||
Group B | Group B [[Coxsackie virus|coxsackie]] viruses are transmitted from person to person by [[Fecal-oral route|fecal-oral]] contamination, direct mouth-to-mouth contact or via [[droplet]] infection. <ref name="pmid20251794">{{cite journal| author=JAMIESON WM, PRINSLEY DM| title=Bornholm disease in the tropics. | journal=Br Med J | year= 1947 | volume= 2 | issue= 4514 | pages= 47-50 | pmid=20251794 | doi=10.1136/bmj.2.4514.47 | pmc=2055212 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20251794 }} </ref> Other people become infected with the [[virus]] if they touch contaminated items then put their fingers in their mouth before washing them properly. Contaminated items can include soiled diapers, shared toys and toilets. [[Epidemic]] [[pleurodynia]] is contagious and occurs in clusters, meaning many people in an area get it around the same time. | ||
Epidemic pleurodynia is contagious and occurs in clusters, meaning many people in an area get it around the same time. | |||
The virus that causes | The virus that causes [[devil's grip]] is a [[picornavirus]]. It is spread by contact and epidemics usually occur during warm weather in temperate regions and at any time in the tropics. It can also be spread through [[saliva]] and feces.<ref>http://www.medicomm.net/Consumer%20Site/dc/dc_b60.htm</ref> Once inside the body via the [[pharynx]], the coxsackie viruses multiplies in the throat and [[intestines]] as well as within the muscles of the [[Chest wall muscles|chest wall]], [[abdominal muscles]] and [[diaphragm]] after which it enters the [[lymphatic tissues]] <ref name="pmid30364740">{{cite journal| author=Lal A, Akhtar J, Isaac S, Mishra AK, Khan MS, Noreldin M | display-authors=etal| title=Unusual cause of chest pain, Bornholm disease, a forgotten entity; case report and review of literature. | journal=Respir Med Case Rep | year= 2018 | volume= 25 | issue= | pages= 270-273 | pmid=30364740 | doi=10.1016/j.rmcr.2018.10.005 | pmc=6197799 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30364740 }} </ref> and subsequently spreads into the bloodstream. At this point, the body's immune defences often can limit the infection and prevent the person from developing symptoms. If the immune defences are less successful, the person starts developing symptoms. | ||
Once viral cells are within host cells, it uses [[autophagy]] to increase [[viral replication]]. Reduced immunity in children may help explain the disease susceptibility in younger children.<ref name="pmid26142496">{{cite journal| author=Sin J, Mangale V, Thienphrapa W, Gottlieb RA, Feuer R| title=Recent progress in understanding coxsackievirus replication, dissemination, and pathogenesis. | journal=Virology | year= 2015 | volume= 484 | issue= | pages= 288-304 | pmid=26142496 | doi=10.1016/j.virol.2015.06.006 | pmc=4567421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26142496 }}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Viral diseases]] | |||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Mature chapter]] | [[Category:Mature chapter]] | ||
[[Category:Infectious diseases]] | [[Category:Infectious diseases]] | ||
[[Category:Up to date]] | |||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Latest revision as of 19:03, 1 December 2022
|
Bornholm disease Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Bornholm disease pathophysiology On the Web |
|
American Roentgen Ray Society Images of Bornholm disease pathophysiology |
|
Risk calculators and risk factors for Bornholm disease pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Arooj Naz, M.B.B.S
Overview
Bornholm disease is a disease caused by one of the group B coxsackie viruses and is less often caused by a group A coxsackie virus or an echovirus, causing pain in the muscles of the chest that join ribs together. The virus is spread by contact and epidemics usually occur during warm weather in temperate regions and at any time in the tropics, primarily through saliva and feces. From within the pharynx, the viruse multiplies in the throat and intestines, the muscles of the chest wall, abdominal muscles and diaphragm after which it enters the lymphatic tissues. The virus uses autophagy to increase viral replication.
Pathophysiology
Group B coxsackie viruses are transmitted from person to person by fecal-oral contamination, direct mouth-to-mouth contact or via droplet infection. [1] Other people become infected with the virus if they touch contaminated items then put their fingers in their mouth before washing them properly. Contaminated items can include soiled diapers, shared toys and toilets. Epidemic pleurodynia is contagious and occurs in clusters, meaning many people in an area get it around the same time.
The virus that causes devil's grip is a picornavirus. It is spread by contact and epidemics usually occur during warm weather in temperate regions and at any time in the tropics. It can also be spread through saliva and feces.[2] Once inside the body via the pharynx, the coxsackie viruses multiplies in the throat and intestines as well as within the muscles of the chest wall, abdominal muscles and diaphragm after which it enters the lymphatic tissues [3] and subsequently spreads into the bloodstream. At this point, the body's immune defences often can limit the infection and prevent the person from developing symptoms. If the immune defences are less successful, the person starts developing symptoms.
Once viral cells are within host cells, it uses autophagy to increase viral replication. Reduced immunity in children may help explain the disease susceptibility in younger children.[4]
References
- ↑ JAMIESON WM, PRINSLEY DM (1947). "Bornholm disease in the tropics". Br Med J. 2 (4514): 47–50. doi:10.1136/bmj.2.4514.47. PMC 2055212. PMID 20251794.
- ↑ http://www.medicomm.net/Consumer%20Site/dc/dc_b60.htm
- ↑ Lal A, Akhtar J, Isaac S, Mishra AK, Khan MS, Noreldin M; et al. (2018). "Unusual cause of chest pain, Bornholm disease, a forgotten entity; case report and review of literature". Respir Med Case Rep. 25: 270–273. doi:10.1016/j.rmcr.2018.10.005. PMC 6197799. PMID 30364740.
- ↑ Sin J, Mangale V, Thienphrapa W, Gottlieb RA, Feuer R (2015). "Recent progress in understanding coxsackievirus replication, dissemination, and pathogenesis". Virology. 484: 288–304. doi:10.1016/j.virol.2015.06.006. PMC 4567421. PMID 26142496.