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| {{Hantavirus pulmonary syndrome}} | | {{Hantavirus infection}} |
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| {{CMG}} | | {{CMG}} ; {{AE}} {{ADG}} |
| | ==Overview== |
| | Hantavirus infection has a diverse epidemiology and demographics due to the vast number of viruses classified under [[hantaviruses]]. The total number of hantavirus pulmonary syndrome (HPS) cases reported in the United States from 2004-2015 is 323. HPS cases have been reported in 30 states, including most of the western half of the country and some eastern states as well. Over half of the confirmed cases have been reported from areas outside the Four Corners area. The mean age of confirmed HPS cases is 38 years (range: 5 to 84 years).<ref name="urlHantavirus Pulmonary Syndrome (HPS) Cases, by State of Exposure | Hantavirus | DHCPP | CDC">{{cite web |url=https://www.cdc.gov/hantavirus/surveillance/state-of-exposure.html |title=Hantavirus Pulmonary Syndrome (HPS) Cases, by State of Exposure | Hantavirus | DHCPP | CDC |format= |work= |accessdate=}}</ref> |
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| ==Epidemiology and Demographics== | | ==Epidemiology== |
| | ===Incidence=== |
| | *Total number of HPS cases reported in the United States from 2004-2015 is 323. |
| | *Total number of HPS cases reported in the United States from 1993-2003 is 336.<ref name="urlAnnual U.S. HPS Cases and Case-Fatality, 1993-2015 | Hantavirus | DHCPP | CDC">{{cite web |url=https://www.cdc.gov/hantavirus/surveillance/annual-cases.html |title=Annual U.S. HPS Cases and Case-Fatality, 1993-2015 | Hantavirus | DHCPP | CDC |format= |work= |accessdate=}}</ref> |
| | *The annual incidence of HPS in Europe is 3,000 per 100,000 persons. |
| | [[Image:HPS Epi-Curve-Cases-fatality.jpg|center|500px|thumb|Source: Centers for disease Control and Prevention www.cdc.gov]] |
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| ''HPS an old disease, newly recognized''
| | ===Case fatality rate=== |
| | The case-mortality rate of [[Hantavirus]] infection is approximately 50% worldwide.<ref name="pmid28120221">{{cite journal |vauthors=Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X |title=Hantavirus infection: a global zoonotic challenge |journal=Virol Sin |volume=32 |issue=1 |pages=32–43 |year=2017 |pmid=28120221 |doi=10.1007/s12250-016-3899-x |url=}}</ref> |
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| Although the high-profile investigation of the HPS syndrome emphasized public health authorities' warnings about new and emerging infectious diseases, HPS has turned out to be a newly identified, but not a "new," disease. In fact, the earliest case of a serologically confirmed SNV infection was in a person who developed an HPS-compatible illness in July 1959 and was found to have IgG antibodies in September 1994. The earliest case of HPS to be confirmed by IHC with direct visualization of hantaviral antigens in postmortem tissue involved a patient who died in 1978.
| | ==Demographics== |
| | ===Age=== |
| | The mean age of confirmed HPS cases is 38 years (range: 5 to 84 years).<ref name="urlHantavirus Pulmonary Syndrome (HPS) Cases, by State of Exposure | Hantavirus | DHCPP | CDC">{{cite web |url=https://www.cdc.gov/hantavirus/surveillance/state-of-exposure.html |title=Hantavirus Pulmonary Syndrome (HPS) Cases, by State of Exposure | Hantavirus | DHCPP | CDC |format= |work= |accessdate=}}</ref> |
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| Hantavirus infection is apparently not deleterious to its rodent reservoir host and is associated with a brisk antibody response against the virion envelope and core proteins and chronic, probably lifelong infection. In natural populations, most infections occur through age-dependent horizontal route(s). The highest antibody prevalence is observed in large (mature) animals. A striking male predilection for hantavirus infection is observed in some rodent species such as harvest mice and deer mice, but not in urban rats (Rattus norvegicus). Horizontal transmission among cage-mates was experimentally demonstrated, but vertical transmission from dam to pup is negligible or absent both in wild and experimental settings.
| | ===Gender=== |
| | Men and women are affected equally by hantavirus infection but of persons ill with hantavirus cardiopulmonary syndrome, 63% have been male, 37% female. |
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| Outbreaks of hantaviral disease have been associated with changes in rodent population densities, which may vary greatly across time, both seasonally and from year to year. Cycles respond to such extrinsic factors as interspecific competition, climatic changes, and predation. Spring and summer outbreaks of HFRS in agricultural settings in Asia and Europe are linked to human contact with field rodents through the planting and harvesting of crops. PUU outbreaks in Scandinavia and the HPS outbreak in the Four Corners region of the United States were associated with natural rodent population increases, followed by invasion of buildings by rodents. The ecologic events that led to 1994 and 1996 outbreaks of Andes virus-HPS in Patagonia, a region in southern South America, are being investigated. Human interventions, such as the introduction of Old World plant species (e.g., rosas mosquetas and Scottish brougham) to Patagonia, with associated alteration in rodent population dynamics, have been suggested as possible factors. Recent fires and a mild winter in Argentina's Rio Negro and Chubut Provinces may also have had a positive effect on the carrier rodent, the colilargo, Oligoryzomys longicaudatus (M. Christie and O. Pearson, pers. comm.).
| | ===Race=== |
| | There is no racial predilection for hantavirus infection. However, Whites currently account for 78% of all cases. American Indians account for about 18% of cases, African Americans for 1% of cases, and Asians for 1% of cases. Of cases with known ethnicity, 19% of HPS cases have been reported among Hispanics (ethnicity considered separately from race). |
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| Although the aerosol route of infection is undoubtedly the most common means of transmission among rodents and to humans, virus transmission by bite may occur among certain rodents and may also occasionally result in human infection (often inside a closed space, such as a rodent-infested grain silo, garage, or outbuilding used for food storage). Epidemiologic investigations have linked virus exposure to such activities as heavy farm work, threshing, sleeping on the ground, and military exercises. Indoor exposure was linked to invasion of homes by field rodents during cold weather or to nesting of rodents in or near dwellings. Genetic sequencing of rodent- and patient-associated viruses has been used to pinpoint the precise locations of human infections, which has supported the role of indoor exposure in hantavirus transmission (32,33). Many hantavirus infections have occurred in persons of lower socioeconomic status because poorer housing conditions and agricultural activities favor closer contact between humans and rodents. However, suburbanization, wilderness camping, and other outdoor recreational activities have spread infection to persons of middle and upper incomes.
| | ===Geographic distrubution=== |
| | | *Of total 659 HPS cases reported in the United States, 96% occurred in states west of the Mississippi River. |
| Nosocomial transmission of hantaviruses has not been documented until very recently and must be regarded as rare. However, viruses have been isolated from blood and urine of HFRS patients, so exposure to bodily fluids of infected persons could result in secondary transmission. Only rarely have multiple North American HPS cases been associated with particular households or buildings. During recent outbreaks of HPS in South America, however, clustering of cases in households and among personal contacts appeared to be more common (M. Christie, pers. comm.). During a recent outbreak of Andes-virus-associated HPS in Patagonia, a Buenos Aires physician apparently contracted the infection after minimal exposure to infected patient blood (34; D.A. Pirola, pers. comm.). An adolescent patient in Buenos Aires apparently contracted hantavirus infection from her parents, who were infected in Patagonia. This unprecedented observation of apparent person-to-person spread of a hantavirus clearly requires laboratory confirmation, especially by careful comparative analysis of the viral sequences.
| | *HPS cases have been reported in 30 states, including most of the western half of the country and some eastern states as well. Over half of the confirmed cases have been reported from areas outside the Four Corners area. |
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| Hantaviruses have also caused several laboratory-associated outbreaks of [[HFRS]]. Laboratory-acquired infections were traced to persistently infected rats obtained from breeders, to wild-caught, naturally infected rodents, or to experimentally infected rodents. No illnesses due to laboratory infections have been reported among workers using cell-culture adapted viruses, although asymptomatic seroconversions have been documented.
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| '''Hantavirus Distribution and Disease-causing Potential'''
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| The worldwide distribution of rodents known to harbor hantaviruses suggests great disease-causing potential. Each hantavirus appears to have a single predominant natural reservoir. With rare exception, the phylogenetic interrelationships among the viruses and those of their predominant host show remarkable concordance. These observations suggest that hantaviruses do not adapt readily to new hosts and that they are closely adapted for success in their host, possibly because of thousands of years of coexistence. As many as three hantaviruses can be found in a particular geographic site, each circulating in its own rodent reservoir, with no apparent evolutionary influence on one another.
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| [[Image:Schmfig.gif|left|Phylogeny of hantaviruses and their relationships to natural reservoirs.]]
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| ''Figure. Phylogeny of hantaviruses and their relationships to natural reservoirs. The trees were constructed by comparing the complete coding regions of the S segments of hantaviruses or of 330 nucleotides corresponding to those of the M segment of Hantaan virus (strain 76118) from nucleotides 1987 to 2315. Abrreviations for viruses are as in Table 1. For each analysis, a single most parsimonious tree was derived by using PAUP 3.1.1 software. For the S segment tree, boostrap values resulting from 100 replications were all greater than 87% except for the branch leading to BCC (78%) and the branch leading to DOB (52%). The next most common placing of DOB was on a branch with HTN.''
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| All known hantaviruses, except Thotta-palayam (TPM) virus, have been isolated or detected in murid rodents. Because only one isolate of TPM virus was made from a shrew (Order Insectivora), it is not clear if Suncus is the true primary reservoir or an example of a "spillover" host, i.e., a secondary host infected through contact with the primary host. Spillover is common in sympatric murid rodents, including those identified as the predominant carrier of another hantavirus; thus, the opportunity for genetic exchange among hantaviruses is present in nature. Spillover hosts are believed to have little or no impact on hantaviral distribution or associated disease. However, rodents other than the primary reservoirs can play an important carrier role. For example, Microtus rossiaemeri-dionalis may play a role in maintenance of Tula virus in some settings, and Peromyscus leucopus and Peromyscus boylii can be important reservoirs for SN virus in the western United States (T. Yates and B. Hjelle, unpub. data). Apparent spillover may also be the result of laboratory errors such as polymerase chain reaction (PCR) contamination or misidentification of rodent species. However, spillover is probably under-appreciated in many studies that rely on reverse transcriptase PCR for identifying specific viruses because many primer pairs may not detect an unexpected spillover virus. In either case, because mistaken identities and cell culture contaminations with other hantaviruses have occasionally been reported, investigators should verify unusual findings to prevent further confusion.
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| '''Epidemiology in the Virology Laboratory'''
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| During the outbreak in 1993, definitive proof that the agent causing HPS was a novel hantavirus was obtained using a genetic detection assay. Oligonucleotide primers were designed on the basis of regions of the M segment (G2 coding region) conserved among hantaviruses and were used in a nested RT-PCR assay to amplify hantavirus-specific DNA fragments from RNA extracted from the tissues of patients. The amplified DNA fragments were then sequenced. Comparative and phylogenetic analyses of derived sequence data demonstrated that the hantavirus associated with the HPS outbreak (SNV) was a novel virus most closely related to Prospect Hill virus (PHV). In addition, a direct genetic link was made between the human HPS cases and the virus harbored by peridomestic P. maniculatus rodents. Characterization of hantaviral genetic sequences recovered from human tissues demonstrated that these sequences were identical to those from rodents captured at the site of the patient's presumed infection. This characterization has continued to facilitate identification of the site of infection when more than one such site exists and therefore focus the public health response. These techniques also allow implication of a specific rodent host in areas of overlapping hosts.
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| '''Hantavirus Pulmonary Syndrome Case Count and Descriptive Statistics in the U.S.'''
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| *Through March 26, 2007, a total of 465 cases of hantavirus pulmonary syndrome have been reported in the United States. The case count started when the disease was first recognized in May 1993. Thirty-five percent of all reported cases have resulted in death. | |
| *Of persons ill with HPS, 64% have been male, 37% female.
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| *The mean age of confirmed case patients is 38 years (range: 10 to 83 years).
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| *HPS can strike anyone; however, whites currently account for 78% of all cases. American Indians account for about 19% of cases, African Americans for 2% of cases, and Asians for 1% of cases. About 14% of HPS cases have been reported among Hispanics (ethnicity considered separately from race). | |
| *Cases have been reported in 30 states, including most of the western half of the country and some eastern states as well. Over half of the confirmed cases have been reported from areas outside the Four Corners area.
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| *About three-quarters of patients with HPS have been residents of rural areas. | | *About three-quarters of patients with HPS have been residents of rural areas. |
| | [[Image:HPS US ByStateOfReporting.jpg|center|500px|thumb|Source: Centers for disease Control and Prevention www.cdc.gov]] |
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| Slide 1: Hantavirus pulmonary syndrome cases by outcome
| | == References == |
| [[Image:Episl2.gif|left|Hantavirus pulmonary syndrome cases by outcome between January 1993 and March 26, 2007]]
| | {{Reflist|2}} |
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| | {{WH}} |
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| Slide 2: Characteristics of HPS Case-Patients, United States
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| [[Image:Episl4.gif|left|Characteristics of HPS Case-Patients, United States]]
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| Slide 3: Hantavirus pulmonary syndrome cases by state of residence
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| [[Image:Episl5.gif|left|Hantavirus pulmonary syndrome cases by state of residence]]
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| '''Outbreaks of HPS in South and Central America'''
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| ''Argentina''
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| An outbreak of 18 cases of hantavirus pulmonary syndrome (HPS) occurred in the southern Andean city of El Bolson, in the Rio Negro Province of Argentina, between September 22 and December 5, 1996. All of these cases displayed the common characteristics of HPS. However, some patients displayed a flushed facial appearance reminiscent of some viral hemorrhagic fevers.
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| Research performed on the lung and liver tissues of a patient who had died of the same disease in this region March of 1995, identified a new hantavirus, named Andes virus, by polymerase chain reaction.
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| All of the people who became sick during the outbreak were either permanent residents of the El Bolson area, or had been visitors to it between two and five weeks before their admission to the hospital. In addition, three doctors who treated patients with the disease became ill themselves.
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| One feature of this outbreak that makes it highly unusual for hantaviral-associated illnesses, is that the available data strongly suggests person-to-person transmission. Specifically, the majority of cases had had contact with another cases two to three weeks before becoming ill, and cases tended to become ill within two weeks of each other. This was especially clear in the case of a physician in Buenos Aires (well outside the El Bolson area) who became ill 27 days after taking care of an HPS patient who had been transferred from the outbreak area to Buenos Aires. Person-to-person transmission has never before been observed with any other type of hantavirus, either those causing HPS in North, Central and South America, or those causing HFRS in Europe and Asia.
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| ''Chile''
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| Between August 1 and October 8, 1997, an outbreak of HPS occurred in Chile. A total of 25 cases were reported, including three family case clusters. Officials in Chile requested epidemiological assistance from Special Pathogens Branch at CDC, and a team left for the region on September 24 to investigate the outbreak. Outbreak investigation findings have been published in "An Outbreak of Hantavirus Pulmonary Syndrome, Chile, 1997". The article is available in the EID October - December 1998 issue. In addition, the initial report made by the team is available in the CDC journal Morbidity and Mortality Weekly Report, Vo. 46, No. 40, and may be read online in Adobe Acrobat Reader (pdf) format.
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| CDC is only able to offer the information as listed above. As a U.S government agency, all of the data we have gathered during investigations is reported and available. However, we are limited by the fact that our disease control and surveillance assistance is provided outside our national borders only if formally requested by another nation, and only to the degree that assistance is actually provided. Therefore, our information on HPS outside of the U.S. is somewhat limited. If you are looking for more information on hantaviruses in Chile, please refer to the Ministerio de Salud, Chile (Chilean Ministry of Health).
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| ''Panama''
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| In mid-January 1999, an outbreak of HPS occurred in Panama. The Special Pathogens Branch of the CDC and the Pan-American Health Organization (PAHO) collaborated with health authorities in Panama to investigate the outbreak. For more information on the outbreak investigation, please read the article "Hantavirus Pulmonary Syndrome -- Panama, 1999-2000", published in the Morbidity and Mortality Weekly Report, March 17, 2000.
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| For specific information about this outbreak, please contact the Panama Ministry of Health at: hantapanama@hotmail.com
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| === References ===
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| http://www.cdc.gov/ncidod/diseases/hanta/hps/noframes/phys/epi.htm
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| http://www.cdc.gov/ncidod/diseases/hanta/hps/noframes/phys/virology.htm
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| http://www.cdc.gov/ncidod/EID/vol3no2/schmaljo.htm
| | [[Category:Viral diseases]] |
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| http://www.cdc.gov/ncidod/diseases/hanta/hps/noframes/argtina.htm
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| http://www.cdc.gov/ncidod/diseases/hanta/hps/noframes/caseinfo.htm
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| http://www.cdc.gov/ncidod/diseases/hanta/hps/noframes/epislides/episl2.htm
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| {{Reflist|2}}
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