Zygomycosis pathophysiology: Difference between revisions

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Latest revision as of 19:33, 18 September 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

The clinical hallmark of Zygomycosis is vascular invasion resulting in thrombosis and tissue infarction/necrosis.

References

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 ==Overview==
-Zygomycosis usually is a disease of the skin, but can also occur in the [[sinus]]es or [[gastrointestinal tract]]. In humans it is most prevalent in immunocompromised patients ([[AIDS|HIV/AIDS]], the [[old age|elderly]], [[Severe combined immunodeficiency|SCID]], etc) and patients in [[acidosis]] ([[diabetes]], burns), particularly after barrier injury to the skin or mucus membranes.  Zygomycosis caused by ''Mucorales'' causes a rapidly progressing disease of sudden onset in sick or [[immunodeficiency|immunocompromised]] animals.  ''Entomophthorales'' cause [[chronic]], local infections in otherwise healthy animals.  The important species that cause ''entomophthoromycosis'' are ''Conidiobolus coronatus'', ''C. incongruous'', and ''[[Basidiobolus ranarum]]''. ''Conidiobolus'' infections of the [[upper respiratory system]] have been reported in humans, sheep, horses, and dogs, and ''Basidiobolus'' has been reported less commonly in humans and dogs.<ref name=Greene>{{cite journal |author=Greene C, Brockus C, Currin M, Jones C |title=Infection with Basidiobolus ranarum in two dogs |journal=J Am Vet Med Assoc |volume=221 |issue=4 |pages=528-32, 500 |year=2002 |id=PMID 12184703}}</ref>  Horses are one of the most common domestic animals to be affected by entomophthoromycosis.  ''C. coronatus'' causes lesions in the [[nasal]] and [[oral]] [[mucous membrane|mucosa]] of horses that may cause nasal discharge or difficulty breathing.  ''B. ranarum'' causes large circular nodules on the upper body and neck of horses.<ref>{{cite web | title = Zygomycosis | work = The Merck Veterinary Manual | date = 2006 | url = http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/51118.htm | accessdate = 2007-02-03 }}</ref>  ''Entomophthorales'' is found in soil and decaying plant matter, and specifically ''Basidiobolus'' can be contracted from insects and the feces of reptiles or amphibians. Zygomycosis of the sinuses can extend from the sinuses into the [[orbit]] and the [[cranial vault]], leading to rhinocerebral mucormycosis.
+The clinical hallmark of Zygomycosis is [[vascular]] invasion resulting in [[thrombosis]] and tissue [[infarction]]/[[necrosis]].
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-[[Category:Infectious disease]]
 [[Category:Fungal diseases]]
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Zygomycosis pathophysiology: Difference between revisions

Latest revision as of 19:33, 18 September 2017

Overview

References

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