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| __NOTOC__
| | #Redirect [[Yersinia pestis infection medical therapy]] |
| {{Bubonic plague}}
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| {{CMG}}
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| ==Overview==
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| Antibiotics of choice for bubonic plague include [[streptomycin]], [[chloramphenicol]], [[tetracycline]], [[gentamycin]] and [[doxycycline]].
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| ==Medical Therapy==
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| ===Pharmacotherapy===
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| ====Acute Pharmacotherapies====
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| Vladimir Havkin, an Indian doctor of Russian-Jewish origin, was the first to invent and test a plague antibiotic.
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| The traditional treatments are:
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| *[[Streptomycin]] 30 mg/kg [[intramuscular|IM]] twice daily for 7 days
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| *[[Chloramphenicol]] 25–30 mg/kg single dose, followed by 12.5–15 mg/kg four times daily
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| *[[Tetracycline]] 2 g single dose, followed by 500 mg four times daily for 7–10 days (not suitable for children)
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| More recently,
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| *[[Gentamicin]] 2.5 mg/kg [[intravenous|IV]] or [[intramuscular|IM]] twice daily for 7 days
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| *[[Doxycycline]] 100 mg (adults) or 2.2 mg/kg (children) orally twice daily have also been shown to be effective.<ref name="Mwengee2006">{{cite journal
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| | author=Mwengee W ''et al.''
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| | title=Treatment of Plague with Genamicin or Doxycycline in a Randomized Clinical Trial in Tanzania
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| | year=2006
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| | journal=Clin Infect Dis
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| | volume=42
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| | issue=5
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| | pages=614–21 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Bacterial diseases]]
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| [[Category:Infectious Disease]]
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| [[Category:Epidemics]]
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| [[Category:Pandemics]]
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| [[Category:Zoonoses]]
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| [[Category:Insect-borne diseases]]
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| [[Category:Disease]]
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| [[Category:Needs content]]
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