Kikuchi disease pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Some studies have suggested a [[genetic predisposition]] to the proposed [[autoimmune]] response. Several [[infectious]] candidates have been associated with Kikuchi's disease<ref name="pmid18462833">{{cite journal| author=Atwater AR, Longley BJ, Aughenbaugh WD| title=Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations. | journal=J Am Acad Dermatol | year= 2008 | volume= 59 | issue= 1 | pages= 130-6 | pmid=18462833 | doi=10.1016/j.jaad.2008.03.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18462833 }} </ref>. | Some studies have suggested a [[genetic predisposition]] to the proposed [[autoimmune]] response. Several [[infectious]] candidates have been associated with Kikuchi's disease<ref name="pmid18462833">{{cite journal| author=Atwater AR, Longley BJ, Aughenbaugh WD| title=Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations. | journal=J Am Acad Dermatol | year= 2008 | volume= 59 | issue= 1 | pages= 130-6 | pmid=18462833 | doi=10.1016/j.jaad.2008.03.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18462833 }} </ref>. | ||
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There are many postulates about the [[etiology]] of Kikuchi disease. A [[microbial]]/ [[viral]] or autoimmune cause has been suggested. [[Mycobacterium]] szulgai, [[Yersinia]] and [[Toxoplasma]] have been implicated. More recently there has been growing evidence of the role of [[Epstein-Barr virus]], as well as other [[virus]]es ([[Human herpesvirus 6|HHV6]], [[Human herpesvirus 8|HHV8]], [[Parvovirus B19]], [[HIV]]- and [[HTLV-1]]) in the [[pathogenesis]] of Kikuchi disease. <ref name="PMID22762705">{{cite journal |author=Rammohan A, Cherukuri SD, Manimaran AB, Manohar RR, Naidu RM|title=Kikuchi-Fujimoto Disease: A Sheep in Wolf's Clothing |journal=J Otolaryngol Head Neck Surg|volume=41 |issue=3 |pages=222–226 |year=2012 |month=June|pmid=22762705|}}</ref> But [[serological testing|serologic tests]] including [[antibodies]] to a host of [[virus]]es have consistently proven noncontributory and no viral particles have been identified [[ultrastructure|ultrastructurally]]. | There are many postulates about the [[etiology]] of Kikuchi disease. A [[microbial]]/ [[viral]] or autoimmune cause has been suggested. [[Mycobacterium]] szulgai, [[Yersinia]] and [[Toxoplasma]] have been implicated. More recently there has been growing evidence of the role of [[Epstein-Barr virus]], as well as other [[virus]]es ([[Human herpesvirus 6|HHV6]], [[Human herpesvirus 8|HHV8]], [[Parvovirus B19]], [[HIV]]- and [[HTLV-1]]) in the [[pathogenesis]] of Kikuchi disease. <ref name="PMID22762705">{{cite journal |author=Rammohan A, Cherukuri SD, Manimaran AB, Manohar RR, Naidu RM|title=Kikuchi-Fujimoto Disease: A Sheep in Wolf's Clothing |journal=J Otolaryngol Head Neck Surg|volume=41 |issue=3 |pages=222–226 |year=2012 |month=June|pmid=22762705|}}</ref> But [[serological testing|serologic tests]] including [[antibodies]] to a host of [[virus]]es have consistently proven noncontributory and no viral particles have been identified [[ultrastructure|ultrastructurally]]. | ||
It is now proposed that Kikuchi disease is a nonspecific [[immune reaction|hyperimmune reaction]] to a variety of [[infectious]], chemical, physical and [[neoplastic]] agents | It is now proposed that Kikuchi disease is a nonspecific [[immune reaction|hyperimmune reaction]] to a variety of [[infectious]], chemical, physical and [[neoplastic]] agents. It is possible that Kikuchi disease may represent an exuberant [[T-cell]] mediated [[immune response]] in a [[genetically]] susceptible individual to a variety of non-specific stimuli. <ref name="PMID22762705">{{cite journal |author=Rammohan A, Cherukuri SD, Manimaran AB, Manohar RR, Naidu RM|title=Kikuchi-Fujimoto Disease: A Sheep in Wolf's Clothing |journal=J Otolaryngol Head Neck Surg|volume=41 |issue=3 |pages=222–226 |year=2012 |month=June|pmid=22762705|}}</ref> | ||
===Associated Conditions=== | ===Associated Conditions=== | ||
Kikuchi's disease has been reported to be associated with [[infection]]s such as: | Kikuchi's disease has been reported to be associated with [[infection]]s such as: | ||
*[[Epstein-Barr virus]], | *[[Epstein-Barr virus]], | ||
*[[Human | *[[Human herpesvirus 6]], | ||
*[[Toxoplasmosis]], and | *[[Toxoplasmosis]], and | ||
*[[Human T-lymphotropic virus]] | *[[Human T-lymphotropic virus]] | ||
In addition to [[SLE]], other [[autoimmune]] conditions and manifestations such as [[antiphospholipid syndrome]], [[polymyositis]], [[systemic]] [[juvenile idiopathic arthritis]], [[bilateral]] [[uveitis]], [[arthritis]] and [[cutaneous]] [[necrotizing]] [[vasculitis]] have been linked to Kikuchi disease. | |||
==References== | ==References== | ||
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{{WS}} | {{WS}} | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Needs | [[Category:Needs overview]] | ||
Latest revision as of 18:08, 18 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Some studies have suggested a genetic predisposition to the proposed autoimmune response. Several infectious candidates have been associated with Kikuchi's disease[1].
There are many postulates about the etiology of Kikuchi disease. A microbial/ viral or autoimmune cause has been suggested. Mycobacterium szulgai, Yersinia and Toxoplasma have been implicated. More recently there has been growing evidence of the role of Epstein-Barr virus, as well as other viruses (HHV6, HHV8, Parvovirus B19, HIV- and HTLV-1) in the pathogenesis of Kikuchi disease. [2] But serologic tests including antibodies to a host of viruses have consistently proven noncontributory and no viral particles have been identified ultrastructurally.
It is now proposed that Kikuchi disease is a nonspecific hyperimmune reaction to a variety of infectious, chemical, physical and neoplastic agents. It is possible that Kikuchi disease may represent an exuberant T-cell mediated immune response in a genetically susceptible individual to a variety of non-specific stimuli. [2]
Associated Conditions
Kikuchi's disease has been reported to be associated with infections such as:
In addition to SLE, other autoimmune conditions and manifestations such as antiphospholipid syndrome, polymyositis, systemic juvenile idiopathic arthritis, bilateral uveitis, arthritis and cutaneous necrotizing vasculitis have been linked to Kikuchi disease.
References
- ↑ Atwater AR, Longley BJ, Aughenbaugh WD (2008). "Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations". J Am Acad Dermatol. 59 (1): 130–6. doi:10.1016/j.jaad.2008.03.012. PMID 18462833.
- ↑ 2.0 2.1 Rammohan A, Cherukuri SD, Manimaran AB, Manohar RR, Naidu RM (2012). "Kikuchi-Fujimoto Disease: A Sheep in Wolf's Clothing". J Otolaryngol Head Neck Surg. 41 (3): 222–226. PMID 22762705. Unknown parameter
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