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__NOTOC__
__NOTOC__
{{Herpes zoster}}
{{Herpes zoster}}
{{CMG}}; L. Katie Morrison, MD; '''Associate Editor(s)-In-Chief:''' {{CZ}}
{{CMG}}; L. Katie Morrison, MD; '''Associate Editor(s)-In-Chief:''' {{CZ}}, {{JH}}, {{DN}}.


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==Overview==
The characteristic physical examination finding of herpes zoster is the [[maculopapular]] rash. The rash in typically unilateral and its distribution is confined to one or two adjacent [[dermatomes]]. As the rash crusts and heals in 7-10 days, a post-inflammatory hyperpigmentation of the skin may result. Other findings, such as cranial and peripheral nerves involvement depend on the location of the [[dorsal root ganglia]] involved.


== Physical Examination ==
== Physical Examination ==
<div align="left">
Physical examination findings of herpes zoster depend on the location of the rash, as well as the stage of the disease:
<gallery heights="175" widths="175">
===Rash===
The rash of herpes zoster virus is typically unilateral and does not cross the midline. It follows the distribution of one or two adjacent dermatomes. The rash can involve any area of the body, but the most common sites are the face ([[ophthalmic]] division of [[trigeminal nerve]]), neck ([[cervical]] [[dorsal root ganglia]]) or chest ([[thoracic]] [[dorsal root ganglia]]). The rash is initially an erythematous, [[maculopapular]] rash, but over the next 7-10 days, it progresses to pustules and ulceration, with crusts, scabbing or both. Post-inflammatory hyperpigmentation may develop along the affected dermatome(s) as part of the healing process. In the immunocompromised individuals, the rash may be complicated by skin necrosis and scarring.<ref name="pmid23785227">{{cite journal |vauthors=Cohen KR, Salbu RL, Frank J, Israel I |title=Presentation and management of herpes zoster (shingles) in the geriatric population |journal=P T |volume=38 |issue=4 |pages=217–27 |year=2013 |pmid=23785227 |pmc=3684190 |doi= |url=}}</ref><ref name="pmid10375341">{{cite journal |vauthors=Cohen JI, Brunell PA, Straus SE, Krause PR |title=Recent advances in varicella-zoster virus infection |journal=Ann. Intern. Med. |volume=130 |issue=11 |pages=922–32 |year=1999 |pmid=10375341 |doi= |url=}}</ref>
 
===[[Herpes zoster ophthalmicus]]===
When the rash involves the [[ophthalmic]] division of the [[trigeminal]] nerve, the same characteristic rash will be present in addition to several [[occular]] and head and neck findings which may or may not accompany the rash. These include<ref name="pmid23785227">{{cite journal |vauthors=Cohen KR, Salbu RL, Frank J, Israel I |title=Presentation and management of herpes zoster (shingles) in the geriatric population |journal=P T |volume=38 |issue=4 |pages=217–27 |year=2013 |pmid=23785227 |pmc=3684190 |doi= |url=}}</ref><ref name="pmid18657721">{{cite journal |vauthors=Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA |title=Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency |journal=Neurol Clin |volume=26 |issue=3 |pages=675–97, viii |year=2008 |pmid=18657721 |pmc=2754837 |doi=10.1016/j.ncl.2008.03.011 |url=}}</ref><ref name="pmid16009918">{{cite journal |vauthors=Karmon Y, Gadoth N |title=Delayed oculomotor nerve palsy after bilateral cervical zoster in an immunocompetent patient |journal=Neurology |volume=65 |issue=1 |pages=170 |year=2005 |pmid=16009918 |doi=10.1212/01.wnl.0000167287.02490.76 |url=}}</ref><ref name="pmid12449270">{{cite journal |vauthors=Shaikh S, Ta CN |title=Evaluation and management of herpes zoster ophthalmicus |journal=Am Fam Physician |volume=66 |issue=9 |pages=1723–30 |year=2002 |pmid=12449270 |doi= |url=}}</ref>:
*Hutchinson's sign: a rash on the tip of the nose is a strong predictor of eye involvement
*[[Blepharoconjunctivitis]]: edema and inflammation of the outer eyelids
*[[Keratitis]]: presents with signs of corneal inflammation, which presents with eye pain, redness and [[photophobia]]
*[[Uveitis]]: presents with eye redness and elevated intraocular pressure
*Cranial nerve palsies: herpes zoster virus may involves cranial nerves III, VI and less commonly, IV. Involvement of these cranial nerves may present with pain on eye movement ([[ophthalmoplegia]]), as well as pupillary dilatation with a sluggish reaction to light when cranial nerve III is involved.<ref name="pmid18657721">{{cite journal |vauthors=Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA |title=Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency |journal=Neurol Clin |volume=26 |issue=3 |pages=675–97, viii |year=2008 |pmid=18657721 |pmc=2754837 |doi=10.1016/j.ncl.2008.03.011 |url=}}</ref><ref name="pmid16009918">{{cite journal |vauthors=Karmon Y, Gadoth N |title=Delayed oculomotor nerve palsy after bilateral cervical zoster in an immunocompetent patient |journal=Neurology |volume=65 |issue=1 |pages=170 |year=2005 |pmid=16009918 |doi=10.1212/01.wnl.0000167287.02490.76 |url=}}</ref>
 
===[[Ramsay Hunt Syndrome]]===
Rarely, herpes zoster may present with a [[maculopapular]] rash in the external auditory canal (zoster opticus) or the tympanic membrane. [[Ramsay Hunt Syndrome]] refers to zoster rash in the external auditory canal, the [[tympanic membrane]], the ipsilateral anterior two-thirds of the tongue or hard palate, associated with ipsilateral weakness or paralysis of the facial muscles, due to involvement of cranial nerve VII. Syndrome may be associated with signs of hearing loss, involuntary eye movements and nystagmus.<ref name="pmid23785227">{{cite journal |vauthors=Cohen KR, Salbu RL, Frank J, Israel I |title=Presentation and management of herpes zoster (shingles) in the geriatric population |journal=P T |volume=38 |issue=4 |pages=217–27 |year=2013 |pmid=23785227 |pmc=3684190 |doi= |url=}}</ref><ref name="pmid18657721">{{cite journal |vauthors=Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA |title=Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency |journal=Neurol Clin |volume=26 |issue=3 |pages=675–97, viii |year=2008 |pmid=18657721 |pmc=2754837 |doi=10.1016/j.ncl.2008.03.011 |url=}}</ref><ref name="pmid11459884">{{cite journal |vauthors=Sweeney CJ, Gilden DH |title=Ramsay Hunt syndrome |journal=J. Neurol. Neurosurg. Psychiatr. |volume=71 |issue=2 |pages=149–54 |year=2001 |pmid=11459884 |pmc=1737523 |doi= |url=}}</ref>
 
===Other neurological manifestations===
*[[Cervical]] dermatomal distribution: rash may be followed by a [[lower motor neuron]] ([[LMN]]) weakness in the arm or diaphragmatic weakness<ref name="pmid18657721">{{cite journal |vauthors=Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA |title=Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency |journal=Neurol Clin |volume=26 |issue=3 |pages=675–97, viii |year=2008 |pmid=18657721 |pmc=2754837 |doi=10.1016/j.ncl.2008.03.011 |url=}}</ref><ref name="pmid8891477">{{cite journal |vauthors=Merchut MP, Gruener G |title=Segmental zoster paresis of limbs |journal=Electromyogr Clin Neurophysiol |volume=36 |issue=6 |pages=369–75 |year=1996 |pmid=8891477 |doi= |url=}}</ref>
*[[Thoracic]] dermatomal distribution: may be associated with abdominal muscles weakness, which may result in abdominal [[herniation]]<ref name="pmid18657721">{{cite journal |vauthors=Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA |title=Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency |journal=Neurol Clin |volume=26 |issue=3 |pages=675–97, viii |year=2008 |pmid=18657721 |pmc=2754837 |doi=10.1016/j.ncl.2008.03.011 |url=}}</ref>
 
===Gallery===
 
=====Skin=====
 
(Images shown below courtesy of Charlie Goldberg, M.D., UCSD School of Medicine and VA Medical Center, San Diego, CA)
 
<gallery>
Image:Skin zoster buttocks1.jpg|Herpes Zoster: Coalesced [[vesicle]]s resulting from reactivation of HZV [[infection]].
Image:Skin zoster buttocks2.jpg|Herpes Zoster: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection. 
Image:Skin zoster buttocks4.jpg|Herpes Zoster: [[dermatome|Dermatomally]] distributed vesicles in patient with HZV infection. 
Image:Skin_zoster_buttocks3.jpg|Herpes Zoster: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection.
Image:Herpes zoster4.jpg|Shingles on waist
 
Image:Herpes zoster1.jpg|[[dermatome|Dermatomal]] involvement of [[rash]]
Image:Herpes zoster2.jpg|[[dermatome|Dermatomal]] involvement of skin rash
Image:Herpes zoster chest.jpg|Herpes zoster on the chest
Image:Herpes zoster chest.jpg|Herpes zoster on the chest
Image:Varicella child-ab.jpg
Image:Varicella child-ab.jpg
Image:varicella zoster.jpg|Varicella zoster
Image:varicella zoster.jpg|Varicella zoster
Image:Herpes zoster1.jpg|[[dermatome|Dermatomal]] involvement of [[rash]]
</gallery>
 
<gallery>
Image:skin_herpes_zoster.jpg|Herpes Zoster. <br> (Courtesy of Josh Fierer, M.D. and Charlie Goldberg, M.D.)
Image:c3zoster.jpg|Herpes Zoster C3 Distribution: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection.
Image:c3zoster2.jpg|Herpes Zoster C3 Distribution: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection.
Image:Herpes zoster 5.jpg|Shingles on face
Image:Herpes zoster3.jpg|Shingles on face
Image:Herpes zoster3.jpg|Shingles on face
</gallery>
</gallery>
</div>
 
<gallery>
Image:Herpes zoster 6.jpg|Child with shingles who had a history of [[leukemia]]
Image:Herpes zoster 7.jpg|[[Plantar]] foot [[rash]] caused by herpes zoster
Image:Herpes zoster 8.jpg|[[Vesicle|Vesicular]] [[lesion]]s of Herpes zoster
Image:Herpes zoster9.jpg|The [[pathological|pathologic]] changes seen on the surface of the right unilateral side of this elderly male patient’s tongue and chin, represent a herpes outbreak due to the [[Varicella zoster virus]] (VZV) pathogen.
Image:Herpes zoster 10.jpg|The [[pustule|pustulo-]][[vesicle|vesicular]] [[rash]] on this African-American woman’s face, represents a herpes [[outbreak]] due to the [[Varicella zoster virus]] (VZV) pathogen.
</gallery>
 
<gallery>
Image:Herpes zoster 11.jpg|This 1968 image depicted a number of varicella, or [[chickenpox]] [[lesion]]s on a patient’s back, which were displaying the characteristic “cropping” distribution, or manifesting themselves in clusters, each in a different developmental stage.
Image:Herpes zoster 12.jpg|This patient presented with what was differentially diagnosed as a herpes zoster [[outbreak]] in order to rule out [[syphilis]].
Image:Herpes zoster 13.jpg|This skin disorder was found to be herpes zoster, not [[Syphilis|syphilitic]] in nature as was initially suspected.
Image:Herpes zoster 14.jpg|These skin [[lesion]]s on the forehead of an elderly woman are due to the herpes zoster [[virus]] on the 21st day of the illness.
Image:Herpes zoster 15.JPG|A case of shingles that demonstrates the typical [[dermatome|dermatomal]] distribution, in this case C8/T1
</gallery>
 
=====Head=====
 
<gallery>
 
Image: Herpes_zoster_06.png| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_18.png| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
</gallery>
 
=====Trunk=====
 
<gallery>
 
Image: Herpes_zoster_02.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_03.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_05.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_07.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_14.jpg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_15.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_16.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_17.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
</gallery>
 
=====Extremities=====
 
<gallery>
 
Image: Herpes_zoster_01.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_10.jpg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_11.jpg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
</gallery>
 
=====Neck=====
 
<gallery>
 
Image: Herpes_zoster_04.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_08.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
</gallery>
 
=====Genitourinary System=====
 
<gallery>
 
Image: Herpes_zoster_12.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_13.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_20.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
Image: Herpes_zoster_21.jpeg| Herpes zoster. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=>
 
</gallery>
 
=====Skin=====


(Images shown below courtesy of Charlie Goldberg, M.D., UCSD School of Medicine and VA Medical Center, San Diego, CA)
(Images shown below courtesy of Charlie Goldberg, M.D., UCSD School of Medicine and VA Medical Center, San Diego, CA)
Line 25: Line 149:
Image:Skin_zoster_buttocks3.jpg|Herpes Zoster: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection.
Image:Skin_zoster_buttocks3.jpg|Herpes Zoster: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection.
Image:Herpes zoster4.jpg|Shingles on waist
Image:Herpes zoster4.jpg|Shingles on waist
</gallery>
 
Image:Herpes zoster1.jpg|[[dermatome|Dermatomal]] involvement of [[rash]]
Image:Herpes zoster2.jpg|[[dermatome|Dermatomal]] involvement of skin rash
Image:Herpes zoster chest.jpg|Herpes zoster on the chest
Image:Varicella child-ab.jpg
Image:varicella zoster.jpg|Varicella zoster</gallery>
</div>
</div>


Line 33: Line 162:
Image:c3zoster.jpg|Herpes Zoster C3 Distribution: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection.
Image:c3zoster.jpg|Herpes Zoster C3 Distribution: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection.
Image:c3zoster2.jpg|Herpes Zoster C3 Distribution: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection.
Image:c3zoster2.jpg|Herpes Zoster C3 Distribution: [[dermatome|Dermatomally]] distributed vesicles, many of which have coalesced, in patient with HZV infection.
Image:Herpes zoster2.jpg|[[dermatome|Dermatomal]] involvement of skin rash
Image:Herpes zoster 5.jpg|Shingles on face
Image:Herpes zoster 5.jpg|Shingles on face
Image:Herpes zoster3.jpg|Shingles on face
</gallery>
</gallery>
</div>
</div>
Line 43: Line 172:
Image:Herpes zoster 7.jpg|[[Plantar]] foot [[rash]] caused by herpes zoster
Image:Herpes zoster 7.jpg|[[Plantar]] foot [[rash]] caused by herpes zoster
Image:Herpes zoster 8.jpg|[[Vesicle|Vesicular]] [[lesion]]s of Herpes zoster
Image:Herpes zoster 8.jpg|[[Vesicle|Vesicular]] [[lesion]]s of Herpes zoster
Image:Herpes zoster9.jpg|The [[pathological|pathologic]] changes seen on the surface of the right unilateral side of this elderly male patient’s tongue and chin, represent a herpes outbreak due to the [[Varicella zoster virus]] (VZV) pathogen, which may lay dormant in the [[spinal nerve]] roots through a [[chicken pox]] infected individual’s life, only manifesting its presence through [[outbreak]]s, as Shingles, or herpes zoster. It is caused by the [[Herpes virus|Herpesviridae]] chickenpoxvirus.
Image:Herpes zoster9.jpg|The [[pathological|pathologic]] changes seen on the surface of the right unilateral side of this elderly male patient’s tongue and chin, represent a herpes outbreak due to the [[Varicella zoster virus]] (VZV) pathogen.
Image:Herpes zoster 10.jpg|The [[pustule|pustulo-]][[vesicle|vesicular]] [[rash]] on this African-American woman’s face, represents a herpes [[outbreak]] due to the [[Varicella zoster virus]] (VZV) pathogen, which may lay dormant in the [[spinal nerve]] roots through a [[chickenpox]] infected individual’s life, only manifesting its presence through outbreaks, as Shingles, or herpes zoster. It is caused by the Herpesviridae chickenpoxvirus.
Image:Herpes zoster 10.jpg|The [[pustule|pustulo-]][[vesicle|vesicular]] [[rash]] on this African-American woman’s face, represents a herpes [[outbreak]] due to the [[Varicella zoster virus]] (VZV) pathogen.
</gallery>
</gallery>
</div>
</div>
Line 52: Line 181:
Image:Herpes zoster 11.jpg|This 1968 image depicted a number of varicella, or [[chickenpox]] [[lesion]]s on a patient’s back, which were displaying the characteristic “cropping” distribution, or manifesting themselves in clusters, each in a different developmental stage.
Image:Herpes zoster 11.jpg|This 1968 image depicted a number of varicella, or [[chickenpox]] [[lesion]]s on a patient’s back, which were displaying the characteristic “cropping” distribution, or manifesting themselves in clusters, each in a different developmental stage.
Image:Herpes zoster 12.jpg|This patient presented with what was differentially diagnosed as a herpes zoster [[outbreak]] in order to rule out [[syphilis]].
Image:Herpes zoster 12.jpg|This patient presented with what was differentially diagnosed as a herpes zoster [[outbreak]] in order to rule out [[syphilis]].
Image:Herpes zoster 13.jpg|This skin disorder was found to be herpes zoster, not [[Syphilis|syphilitic]] in nature as was initially suspected.
Image:Herpes zoster 14.jpg|These skin [[lesion]]s on the forehead of an elderly woman are due to the herpes zoster [[virus]] on the 21st day of the illness.
Image:Herpes zoster 15.JPG|A case of shingles that demonstrates the typical [[dermatome|dermatomal]] distribution, in this case C8/T1
</gallery>
</gallery>
</div>
</div>
==Gallery==
<gallery>
Image: Chickenpox31.jpeg| Skin disorder was found to be herpes zoster. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
Image: Chickenpox30.jpeg| Plantar foot rash was suspected to be smallpox related, but was later determined to be caused by herpes zoster virus. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
</gallery>
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Infectious skin diseases]]
 
[[Category:Viral diseases]]
{{WH}}
[[Category:Herpesviruses]]
{{WS}}
[[Category:Infectious disease]]
[[Category:Needs content]]
[[Category:Needs overview]]

Latest revision as of 16:44, 24 October 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; L. Katie Morrison, MD; Associate Editor(s)-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Jesus Rosario Hernandez, M.D. [3], Dima Nimri, M.D. [4].

Overview

The characteristic physical examination finding of herpes zoster is the maculopapular rash. The rash in typically unilateral and its distribution is confined to one or two adjacent dermatomes. As the rash crusts and heals in 7-10 days, a post-inflammatory hyperpigmentation of the skin may result. Other findings, such as cranial and peripheral nerves involvement depend on the location of the dorsal root ganglia involved.

Physical Examination

Physical examination findings of herpes zoster depend on the location of the rash, as well as the stage of the disease:

Rash

The rash of herpes zoster virus is typically unilateral and does not cross the midline. It follows the distribution of one or two adjacent dermatomes. The rash can involve any area of the body, but the most common sites are the face (ophthalmic division of trigeminal nerve), neck (cervical dorsal root ganglia) or chest (thoracic dorsal root ganglia). The rash is initially an erythematous, maculopapular rash, but over the next 7-10 days, it progresses to pustules and ulceration, with crusts, scabbing or both. Post-inflammatory hyperpigmentation may develop along the affected dermatome(s) as part of the healing process. In the immunocompromised individuals, the rash may be complicated by skin necrosis and scarring.[1][2]

Herpes zoster ophthalmicus

When the rash involves the ophthalmic division of the trigeminal nerve, the same characteristic rash will be present in addition to several occular and head and neck findings which may or may not accompany the rash. These include[1][3][4][5]:

  • Hutchinson's sign: a rash on the tip of the nose is a strong predictor of eye involvement
  • Blepharoconjunctivitis: edema and inflammation of the outer eyelids
  • Keratitis: presents with signs of corneal inflammation, which presents with eye pain, redness and photophobia
  • Uveitis: presents with eye redness and elevated intraocular pressure
  • Cranial nerve palsies: herpes zoster virus may involves cranial nerves III, VI and less commonly, IV. Involvement of these cranial nerves may present with pain on eye movement (ophthalmoplegia), as well as pupillary dilatation with a sluggish reaction to light when cranial nerve III is involved.[3][4]

Ramsay Hunt Syndrome

Rarely, herpes zoster may present with a maculopapular rash in the external auditory canal (zoster opticus) or the tympanic membrane. Ramsay Hunt Syndrome refers to zoster rash in the external auditory canal, the tympanic membrane, the ipsilateral anterior two-thirds of the tongue or hard palate, associated with ipsilateral weakness or paralysis of the facial muscles, due to involvement of cranial nerve VII. Syndrome may be associated with signs of hearing loss, involuntary eye movements and nystagmus.[1][3][6]

Other neurological manifestations

Gallery

Skin

(Images shown below courtesy of Charlie Goldberg, M.D., UCSD School of Medicine and VA Medical Center, San Diego, CA)

  • Herpes Zoster: Coalesced vesicles resulting from reactivation of HZV infection.

    Herpes Zoster: Coalesced vesicles resulting from reactivation of HZV infection.

  • Herpes Zoster: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

    Herpes Zoster: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

  • Herpes Zoster: Dermatomally distributed vesicles in patient with HZV infection.

    Herpes Zoster: Dermatomally distributed vesicles in patient with HZV infection.

  • Herpes Zoster: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

    Herpes Zoster: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

  • Shingles on waist

    Shingles on waist

  • Dermatomal involvement of rash

    Dermatomal involvement of rash

  • Dermatomal involvement of skin rash

    Dermatomal involvement of skin rash

  • Herpes zoster on the chest

    Herpes zoster on the chest

  • Varicella zoster

    Varicella zoster

  • Herpes Zoster. (Courtesy of Josh Fierer, M.D. and Charlie Goldberg, M.D.)

    Herpes Zoster.
    (Courtesy of Josh Fierer, M.D. and Charlie Goldberg, M.D.)

  • Herpes Zoster C3 Distribution: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

    Herpes Zoster C3 Distribution: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

  • Herpes Zoster C3 Distribution: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

    Herpes Zoster C3 Distribution: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

  • Shingles on face

    Shingles on face

  • Shingles on face

    Shingles on face

  • This 1968 image depicted a number of varicella, or chickenpox lesions on a patient’s back, which were displaying the characteristic “cropping” distribution, or manifesting themselves in clusters, each in a different developmental stage.

    This 1968 image depicted a number of varicella, or chickenpox lesions on a patient’s back, which were displaying the characteristic “cropping” distribution, or manifesting themselves in clusters, each in a different developmental stage.

  • This patient presented with what was differentially diagnosed as a herpes zoster outbreak in order to rule out syphilis.

    This patient presented with what was differentially diagnosed as a herpes zoster outbreak in order to rule out syphilis.

  • This skin disorder was found to be herpes zoster, not syphilitic in nature as was initially suspected.

    This skin disorder was found to be herpes zoster, not syphilitic in nature as was initially suspected.

  • These skin lesions on the forehead of an elderly woman are due to the herpes zoster virus on the 21st day of the illness.

    These skin lesions on the forehead of an elderly woman are due to the herpes zoster virus on the 21st day of the illness.

  • A case of shingles that demonstrates the typical dermatomal distribution, in this case C8/T1

    A case of shingles that demonstrates the typical dermatomal distribution, in this case C8/T1

Head
Trunk
Extremities
Neck
Genitourinary System
Skin

(Images shown below courtesy of Charlie Goldberg, M.D., UCSD School of Medicine and VA Medical Center, San Diego, CA)

  • Herpes Zoster: Coalesced vesicles resulting from reactivation of HZV infection.

    Herpes Zoster: Coalesced vesicles resulting from reactivation of HZV infection.

  • Herpes Zoster: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

    Herpes Zoster: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

  • Herpes Zoster: Dermatomally distributed vesicles in patient with HZV infection.

    Herpes Zoster: Dermatomally distributed vesicles in patient with HZV infection.

  • Herpes Zoster: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

    Herpes Zoster: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

  • Shingles on waist

    Shingles on waist

  • Dermatomal involvement of rash

    Dermatomal involvement of rash

  • Dermatomal involvement of skin rash

    Dermatomal involvement of skin rash

  • Herpes zoster on the chest

    Herpes zoster on the chest

  • Varicella zoster

    Varicella zoster

  • Herpes Zoster. (Courtesy of Josh Fierer, M.D. and Charlie Goldberg, M.D.)

    Herpes Zoster.
    (Courtesy of Josh Fierer, M.D. and Charlie Goldberg, M.D.)

  • Herpes Zoster C3 Distribution: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

    Herpes Zoster C3 Distribution: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

  • Herpes Zoster C3 Distribution: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

    Herpes Zoster C3 Distribution: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV infection.

  • Shingles on face

    Shingles on face

  • Shingles on face

    Shingles on face

  • This 1968 image depicted a number of varicella, or chickenpox lesions on a patient’s back, which were displaying the characteristic “cropping” distribution, or manifesting themselves in clusters, each in a different developmental stage.

    This 1968 image depicted a number of varicella, or chickenpox lesions on a patient’s back, which were displaying the characteristic “cropping” distribution, or manifesting themselves in clusters, each in a different developmental stage.

  • This patient presented with what was differentially diagnosed as a herpes zoster outbreak in order to rule out syphilis.

    This patient presented with what was differentially diagnosed as a herpes zoster outbreak in order to rule out syphilis.

  • This skin disorder was found to be herpes zoster, not syphilitic in nature as was initially suspected.

    This skin disorder was found to be herpes zoster, not syphilitic in nature as was initially suspected.

  • These skin lesions on the forehead of an elderly woman are due to the herpes zoster virus on the 21st day of the illness.

    These skin lesions on the forehead of an elderly woman are due to the herpes zoster virus on the 21st day of the illness.

  • A case of shingles that demonstrates the typical dermatomal distribution, in this case C8/T1

    A case of shingles that demonstrates the typical dermatomal distribution, in this case C8/T1

Gallery

References

  1. ↑ 1.0 1.1 1.2 Cohen KR, Salbu RL, Frank J, Israel I (2013). "Presentation and management of herpes zoster (shingles) in the geriatric population". P T. 38 (4): 217–27. PMC 3684190. PMID 23785227.
  2. ↑ Cohen JI, Brunell PA, Straus SE, Krause PR (1999). "Recent advances in varicella-zoster virus infection". Ann. Intern. Med. 130 (11): 922–32. PMID 10375341.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA (2008). "Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency". Neurol Clin. 26 (3): 675–97, viii. doi:10.1016/j.ncl.2008.03.011. PMC 2754837. PMID 18657721.
  4. ↑ 4.0 4.1 Karmon Y, Gadoth N (2005). "Delayed oculomotor nerve palsy after bilateral cervical zoster in an immunocompetent patient". Neurology. 65 (1): 170. doi:10.1212/01.wnl.0000167287.02490.76. PMID 16009918.
  5. ↑ Shaikh S, Ta CN (2002). "Evaluation and management of herpes zoster ophthalmicus". Am Fam Physician. 66 (9): 1723–30. PMID 12449270.
  6. ↑ Sweeney CJ, Gilden DH (2001). "Ramsay Hunt syndrome". J. Neurol. Neurosurg. Psychiatr. 71 (2): 149–54. PMC 1737523. PMID 11459884.
  7. ↑ Merchut MP, Gruener G (1996). "Segmental zoster paresis of limbs". Electromyogr Clin Neurophysiol. 36 (6): 369–75. PMID 8891477.
  8. ↑ 8.0 8.1 "Public Health Image Library (PHIL)".


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