Stevens-Johnson syndrome epidemiology and demographics: Difference between revisions

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==Overview==
SJS is a rare condition, with a reported incidence of around 2-7 per 1000,000 people per year and a mean mortality rate of 4.8 percent. It is seen in patients of all age groups but particularly in children and young adults. Females are more commonly affected than males
 
==Epidemiology and Demographics==
===Incidence===
*The incidence of SJS is approximately 2-7 per 1000,000 individuals per year.<ref name="pmid2036028">{{cite journal| author=Strom BL, Carson JL, Halpern AC, Schinnar R, Snyder ES, Shaw M et al.| title=A population-based study of Stevens-Johnson syndrome. Incidence and antecedent drug exposures. | journal=Arch Dermatol | year= 1991 | volume= 127 | issue= 6 | pages= 831-8 | pmid=2036028 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2036028  }}</ref>
*The incidences of SJS, SJS-TEN, and TEN were found to be a mean 5.3, 0.8, and 0.4 cases per million children per year in the US<ref name="pmid28285784">{{cite journal| author=Hsu DY, Brieva J, Silverberg NB, Paller AS, Silverberg JI| title=Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States. | journal=J Am Acad Dermatol | year= 2017 | volume= 76 | issue= 5 | pages= 811-817.e4 | pmid=28285784 | doi=10.1016/j.jaad.2016.12.024 | pmc=5502094 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28285784  }}</ref>
*The mean estimated incidences of SJS, SJS/TEN, and TEN were found to be 9.2, 1.6, and 1.9 per million adults per year in the US<ref name="pmid27039263">{{cite journal| author=Hsu DY, Brieva J, Silverberg NB, Silverberg JI| title=Morbidity and Mortality of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in United States Adults. | journal=J Invest Dermatol | year= 2016 | volume= 136 | issue= 7 | pages= 1387-1397 | pmid=27039263 | doi=10.1016/j.jid.2016.03.023 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27039263  }}</ref>
 
===Case-fatality rate/Mortality rate===
*Between years 2009-2012, the Mean adjusted mortality was 4.8% for SJS, 19.4% for SJS/TEN, and 14.8% for TEN<ref name="pmid270392632">{{cite journal| author=Hsu DY, Brieva J, Silverberg NB, Silverberg JI| title=Morbidity and Mortality of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in United States Adults. | journal=J Invest Dermatol | year= 2016 | volume= 136 | issue= 7 | pages= 1387-1397 | pmid=27039263 | doi=10.1016/j.jid.2016.03.023 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27039263  }}</ref>


==Overview==
===Age===
SJS is a rare condition, with a reported incidence of around one case per 100,000 people per year.
*Patients of all age groups may develop SJS.
==References==
{{reflist|2}}


[[Category:Dermatology]]
===Race===
[[Category:Medical emergencies]]
*The incidence of SJS might be higher in Non White/Multiracial people as compared to White{{cite web |url=https://doi.org/10.1016/j.jid.2016.03.023 |title=Redirecting |format= |work= |accessdate=}}
[[Category:Emergency medicine]]
===Gender===
[[Category:Disease]]
*Women are more commonly affected by SJS than males{{cite web |url=https://doi.org/10.1016/j.jid.2016.03.023 |title=Redirecting |format= |work= |accessdate=}}.
[[Category:Needs content]]


==References==
{{Reflist|2}}


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Latest revision as of 21:38, 29 August 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anila Hussain, MD [2]

Overview

SJS is a rare condition, with a reported incidence of around 2-7 per 1000,000 people per year and a mean mortality rate of 4.8 percent. It is seen in patients of all age groups but particularly in children and young adults. Females are more commonly affected than males

Epidemiology and Demographics

Incidence

  • The incidence of SJS is approximately 2-7 per 1000,000 individuals per year.[1]
  • The incidences of SJS, SJS-TEN, and TEN were found to be a mean 5.3, 0.8, and 0.4 cases per million children per year in the US[2]
  • The mean estimated incidences of SJS, SJS/TEN, and TEN were found to be 9.2, 1.6, and 1.9 per million adults per year in the US[3]

Case-fatality rate/Mortality rate

  • Between years 2009-2012, the Mean adjusted mortality was 4.8% for SJS, 19.4% for SJS/TEN, and 14.8% for TEN[4]

Age

  • Patients of all age groups may develop SJS.

Race

  • The incidence of SJS might be higher in Non White/Multiracial people as compared to White"Redirecting".

Gender

  • Women are more commonly affected by SJS than males"Redirecting"..

References

  1. ↑ Strom BL, Carson JL, Halpern AC, Schinnar R, Snyder ES, Shaw M; et al. (1991). "A population-based study of Stevens-Johnson syndrome. Incidence and antecedent drug exposures". Arch Dermatol. 127 (6): 831–8. PMID 2036028.
  2. ↑ Hsu DY, Brieva J, Silverberg NB, Paller AS, Silverberg JI (2017). "Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States". J Am Acad Dermatol. 76 (5): 811–817.e4. doi:10.1016/j.jaad.2016.12.024. PMC 5502094. PMID 28285784.
  3. ↑ Hsu DY, Brieva J, Silverberg NB, Silverberg JI (2016). "Morbidity and Mortality of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in United States Adults". J Invest Dermatol. 136 (7): 1387–1397. doi:10.1016/j.jid.2016.03.023. PMID 27039263.
  4. ↑ Hsu DY, Brieva J, Silverberg NB, Silverberg JI (2016). "Morbidity and Mortality of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in United States Adults". J Invest Dermatol. 136 (7): 1387–1397. doi:10.1016/j.jid.2016.03.023. PMID 27039263.

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