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{{Budd-Chiari syndrome}}
{{Budd-Chiari syndrome}}
{{CMG}}
{{CMG}}; {{AE}}{{Mazia}}
 
==Overivew==
Approximately 80 percent of [[patients]] with the Budd-Chiari syndrome have an underlying [[disorder]]. Many patients may have more than one [[risk factor]]. Same patients may have multiple [[causes]] that predispose to the [[development]] of Budd-Chiari Syndrome. Associated risk factors include [[hematologic]] disorders, [[coagulopathies]], [[chronic]] [[infections]], [[chronic]] [[inflammatory diseases]], [[tumors]], [[congenital]] membranous obstructions.


==Risk Factors==
==Risk Factors==
* Estrogen-containing (combined) forms of [[hormonal contraception]]
*Approximately 80 percent of [[patients]] with the [[Budd-Chiari syndrome]] have an underlying disorder. Many [[patients]] may have more than one [[Risk factors|risk factor]]. Same [[patient]] may have multiple [[causes]] that predispose to the [[development]] of Budd-Chiari Syndrome.<ref name="pmid26668741">{{cite journal |vauthors=Martens P, Nevens F |title=Budd-Chiari syndrome |journal=United European Gastroenterol J |volume=3 |issue=6 |pages=489–500 |year=2015 |pmid=26668741 |pmc=4669515 |doi=10.1177/2050640615582293 |url=}}</ref><ref name="pmid27326316">{{cite journal |vauthors=Shin N, Kim YH, Xu H, Shi HB, Zhang QQ, Colon Pons JP, Kim D, Xu Y, Wu FY, Han S, Lee BB, Li LS |title=Redefining Budd-Chiari syndrome: A systematic review |journal=World J Hepatol |volume=8 |issue=16 |pages=691–702 |year=2016 |pmid=27326316 |pmc=4909431 |doi=10.4254/wjh.v8.i16.691 |url=}}</ref>
* [[Pregnancy]]
*Associated [[risk factors]] include:
* [[Paroxysmal nocturnal hemoglobinuria]]<ref>Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1995 Nov 9;333(19):1253-8.</ref> and 12% may acquire Budd-Chiari. <ref>Socie G, Mary JY, de Gramont A, Rio B, Leporrier M, Rose C, Heudier P, Rochant H, Cahn JY, Gluckman E. Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. French Society of Haematology. Lancet. 1996 Aug 31;348(9027):573-7. </ref>
*[[Hematologic]] disorders including:
**[[Polycythemia rubra vera]]
**[[Paroxysmal nocturnal hemoglobinuria]]
**[[Myeloproliferative disease|myeloproliferative disorder]]
**[[Antiphospholipid antibody syndrome]]
**[[Essential thrombocytosis]]
**[[Inherited]] [[thrombotic]] diathesis
 
*[[Coagulopathies]] include the following:
**[[Protein C deficiency]]
**[[Protein S deficiency]]
**[[Antithrombin III]] [[deficiency]]
**[[Factor V Leiden]] [[deficiency]]
*[[Chronic]] [[infections]] like:
**[[Hydatid cyst|Hydatid cysts]]
**[[Aspergillosis]]
**[[Amoebic liver abscess causes|Amebic abscess]]
**[[Syphilis]]
**[[Tuberculosis]]
*[[Chronic]] [[inflammatory diseases]] such as:
**[[Behçet disease]]
**[[Inflammatory bowel disease]]
**[[Sarcoidosis]]
**[[Systemic lupus erythematosus]]
**[[Sjögren's Syndrome|Sjögren syndrome]]
**[[Mixed connective tissue disease|Mixed connective-tissue disease]]
*[[Tumors]] such as
**[[Hepatocellular carcinoma|Hepatocellular carcinoma (HCC)]]
**[[Renal cell carcinoma]]
**[[Leiomyosarcoma]]
**[[Adrenal carcinoma]]
**[[Wilms' tumor|Wilms tumor]]
**[[Right atrial myxoma]]
*[[Congenital]] membranous obstructions that include the following:
**Type I: Thin membrane is present in the [[vena cava]] or the [[atrium]]
**Type II: A part of the [[vena cava]] is absent
**Type III: The [[Inferior vena cava|inferior vena cava (IVC)]] cannot be filled, and [[collaterals]] have developed
*Miscellaneous [[risk factors]] of Budd-Chiari syndrome include the following:
**[[Alpha1-antitrypsin deficiency]]
**[[Dacarbazine]]
**Urethane
**[[Hypoplasia]] of the [[Hepatic veins|suprahepatic veins]]
**[[Postsurgical]] [[obstruction]]
**Posttraumatic [[obstruction]]
**[[Total parenteral nutrition|Total parenteral nutrition (TPN)]]: Budd-Chiari syndrome can be a [[complication]] of [[total parenteral nutrition]] ([[TPN]]) via an [[inferior vena cava]] ([[Inferior vena cava|IVC]]) [[catheter]] in a [[neonate]]


==References==
==References==
{{Reflist|2}}


{{Reflist|2}}
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[[Category:Hepatology]]
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Latest revision as of 18:02, 30 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]

Overivew

Approximately 80 percent of patients with the Budd-Chiari syndrome have an underlying disorder. Many patients may have more than one risk factor. Same patients may have multiple causes that predispose to the development of Budd-Chiari Syndrome. Associated risk factors include hematologic disorders, coagulopathies, chronic infections, chronic inflammatory diseases, tumors, congenital membranous obstructions.

Risk Factors

References

  1. Martens P, Nevens F (2015). "Budd-Chiari syndrome". United European Gastroenterol J. 3 (6): 489–500. doi:10.1177/2050640615582293. PMC 4669515. PMID 26668741.
  2. Shin N, Kim YH, Xu H, Shi HB, Zhang QQ, Colon Pons JP, Kim D, Xu Y, Wu FY, Han S, Lee BB, Li LS (2016). "Redefining Budd-Chiari syndrome: A systematic review". World J Hepatol. 8 (16): 691–702. doi:10.4254/wjh.v8.i16.691. PMC 4909431. PMID 27326316.

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