PLATO bleeding criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

PLATO Bleeding Classification

“

1. Major Life-threatening: Fatal Intracranial Intrapericardial with cardiac tamponade Resulting in hypovolemic shock or severe hypotension that requires pressors or surgery Clinically overt or apparent bleeding associated with decrease in hemoglobin >5 g/dL Requiring transfusion of ≥4 U whole blood or PRBCs Other Major Significantly disabling (eg, intraocular with permanent vision loss) Associated drop in hemoglobin of 3 to 5 g/dL Requiring transfusion of 2 to 3 U whole blood or PRBCs Any Major Any one of the above criteria 2. Minor Requiring medical intervention to stop or treat bleeding (e.g., epistaxis requiring visit to medical facility for packing) 3. Minimal All others (e.g., bruising, bleeding gums, oozing from injection sites) not requiring intervention or treatment

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