Drug induced liver injury causes: Difference between revisions
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{{Drug | {{Drug induced liver injury}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{Rachita}} | ||
==Overview== | |||
Hundreds of prescription and nonprescription medications as well as supplements have been implicated in drug induced liver injury. A free searchable database of causative agents is available through the [https://livertox.nlm.nih.gov/ National Institute of Health]. | |||
==Causes== | ==Causes== | ||
===Common Causative Agents:=== | |||
*[[Acetaminophen]] | |||
*[[Azithromycin]] | |||
*[[Ethanol]] | |||
*[[Statins]] | |||
*[[Tetracycline]] | |||
*[[Rosiglitazone]] | |||
*[[Amiodarone]] | |||
*[[Valproic Acid]] | |||
*[[Methotrexate]] | |||
*[[Isoniazid]] | |||
*[[Rifampin]] | |||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Drug Side Effect''' | | '''Drug Side Effect''' | ||
|bgcolor="Beige"| [[5-Azacytidine]], [[Abacavir]], [[Abiraterone]], [[Agomelatine]], [[Albendazole]], [[Allopurinol]], [[Altretamine]], [[Amineptine]], [[Amiodarone]], [[Amitriptyline]], [[Amoxicillin]], [[Amphotericin B]], [[Amprenavir]], [[Anabolic steroids]], [[Antituberculosis drugs]], [[Apixaban]], [[Arsenic trioxide]], [[Asafetida]], [[Asparaginase]], [[Atorvastatin]], [[Atovaquone]], [[Azathioprine]], [[Benoxaprofen]], [[Bexarotene]], [[Black cohosh extract]], [[Bosentan]], [[Bosutinib]], [[Bromfenac]], [[Bumetanide]], [[Carfilzomib]], [[Cascara]], [[Caspofungin]], [[Chaparral]], [[Chenodeoxycholic acid]], [[Chlormezanone]], [[Chlorzoxazone]], [[Ciprofloxacin]], [[Clofarabine]], [[Combined oral contraceptive pill]], [[Comfrey]], [[Crizotinib]], [[Cyclobenzaprine]], [[Dantrolene]], [[Daptomycin]], [[Dasatinib]], [[Deferasirox]], [[Desipramine]], [[Diclofenac]], [[Disulfiram]], [[Docetaxel]], [[Donepezil]], [[Dothiepin]], [[Dronedarone]], [[Eltrombopag]], [[Emtricitabine]], [[Entecavir]], [[Ephedra]], [[Erlotinib]], [[Erythromycin estolate]], [[Ethanol]], [[Ethinylestradiol]], [[Ethionamide]], [[Etretinate]], [[Febuxostat]], [[Felbamate]], [[Fenofibrate]], [[Fingolimod]], [[Fluconazole]], [[Flucytosine]], [[Fluoxymesterone]], [[Flutamide]], [[Fluvastatin]], [[Fosamprenavir]], [[Frusemide]], [[Fusidic acid]], [[Ganciclovir]], [[Gemcitabine]], [[Gemtuzumab ozogamicin]], [[Gold salts]], [[Golimumab]], [[Halothane]], [[Imatinib mesylate]], [[Imipenem]], [[Interferon alpha]], [[Interferon beta]], [[Interleukin 2]], [[Ipilimumab]], [[Isoniazid]], [[Isotretinoin]], [[Kava root extract]], [[Ketoconazole]], [[Lapatinib ditosylate]], [[Leflunomide]], [[Lovastatin]], [[Maraviroc]], [[Meropenem]], [[Mesalazine]], [[Methotrexate | |bgcolor="Beige"| [[5-Azacytidine]], [[Abacavir]], [[Abiraterone]], [[Acetaminophen]], [[Agomelatine]], [[Albendazole]], [[Allopurinol]], [[Altretamine]], [[Amineptine]], [[Amiodarone]], [[Amitriptyline]], [[Amoxicillin]], [[Amphotericin B]], [[Amprenavir]], [[Anabolic steroids]], [[Antituberculosis drugs]], [[Apixaban]], [[Arsenic trioxide]], [[Asafetida]], [[Asparaginase]], [[Atorvastatin]], [[Atovaquone]], [[Azathioprine]], [[Benoxaprofen]], [[Bexarotene]], [[Black cohosh extract]], [[Bosentan]], [[Bosutinib]], [[Bromfenac]], [[Bumetanide]], [[Carfilzomib]], [[Cascara]], [[Caspofungin]], [[Chaparral]], [[Chenodeoxycholic acid]], [[Chlormezanone]], [[Chlorzoxazone]], [[Ciprofloxacin]], [[Clofarabine]], [[Combined oral contraceptive pill]], [[Comfrey]], [[Crizotinib]], [[Cyclobenzaprine]], [[Dantrolene]], [[Daptomycin]], [[Dasatinib]], [[Deferasirox]], [[Desipramine]], [[Diclofenac]], [[Disulfiram]], [[Docetaxel]], [[Donepezil]], [[Dothiepin]], [[Dronedarone]], [[Eltrombopag]], [[Emtricitabine]], [[Entecavir]], [[Ephedra]], [[Erlotinib]], [[Erythromycin estolate]], [[Ethanol]], [[Ethinylestradiol]], [[Ethionamide]], [[Etretinate]], [[Febuxostat]], [[Felbamate]], [[Fenofibrate]], [[Fingolimod]], [[Fluconazole]], [[Flucytosine]], [[Fluoxymesterone]], [[Flutamide]], [[Fluvastatin]], [[Fosamprenavir]], [[Frusemide]], [[Fusidic acid]], [[Ganciclovir]], [[Gemcitabine]], [[Gemtuzumab ozogamicin]], [[Gold salts]], [[Golimumab]], [[Halothane]], [[Imatinib mesylate]], [[Imipenem]], [[Interferon alpha]], [[Interferon beta]], [[Interleukin 2]], [[Ipilimumab]], [[Isoniazid]], [[Isotretinoin]], [[Kava root extract]], [[Ketoconazole]], [[Lapatinib ditosylate]], [[Leflunomide]], [[Lovastatin]], [[Maraviroc]], [[Meropenem]], [[Mesalazine]], [[Methotrexate]], [[Methyldopa]], [[Methyldopate]], [[Micafungin]], [[Minocycline]], [[Mirtazapine]], [[Mithramycin]], [[Naltrexone]], [[Nandrolone]], [[Natalizumab]], [[Nelfinavir]], [[Nevirapine]], [[Niacin]], [[Nicotinic acid]], [[Nimesulide]], [[Nitisinone]], [[Nitrofurantoin]], [[Norfloxacin]], [[Nortriptyline]], [[Ondansetron]], [[Oxyphenisatine]], [[Paclitaxel]], [[Para-amino salicylic acid]], [[Pazopanib]], [[Pegvisomant]], [[Pemoline]], [[Pentostatin]], [[Phenelzine]], [[Phenylbutazone]], [[Phenytoin]], [[Pralatrexate]], [[Pravastatin]], [[Procainamide]], [[Propylthiouracil]], [[Prothionamide]], [[Pyrazinamide]], [[Pyritinol]], [[Pyrrolizidine alkaloids]], [[Regorafenib]], [[Rifabutin]], [[Rifampicin]], [[Riluzole]], [[Ritonavir]], [[Rivaroxaban]], [[Rosuvastatin]], [[Saquinavir]], [[Simvastatin]], [[Sitaxentan]], [[Sorafenib]], [[Stanozolol]], [[Statins]], [[Succimer]], [[Suloctidil]], [[Sulphasalazine]], [[Sulphinpyrazone]], [[Tegafur]], [[Telithromycin]], [[Teriflunomide]], [[Thiabendazole]], [[Thioguanine]], [[Ticlopidine]], [[Tipranavir]], [[Tizanidine]], [[Tolbutamide]], [[Tolcapone]], [[Tolrestat]], [[Trabectedin]], [[Troglitazone]], [[Trovafloxacin]], [[Ursodeoxycholic acid]], [[Valganciclovir]], [[Valproic acid]], [[Velnacrine]], [[Verapamil]], [[Voriconazole]], [[Ximelagatran]], [[Zotepine]], [[Alcohol]], [[Carbimazole]], [[Phenothiazines]], [[Clofibrate]], [[Tetracyclines]] | ||
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|} | |} | ||
===Causes in Alphabetical Order=== | ===Causes in Alphabetical Order=== | ||
{{MultiCol}} | |||
*[[5-Azacytidine]] | *[[5-Azacytidine]] | ||
*[[Abacavir]] | *[[Abacavir]] | ||
*[[Abiraterone]] | *[[Abiraterone]] | ||
*[[Acetaminophen]] | |||
*[[Agomelatine]] | *[[Agomelatine]] | ||
*[[Albendazole]] | *[[Albendazole]] | ||
| Line 158: | Line 177: | ||
*[[Ciprofloxacin]] | *[[Ciprofloxacin]] | ||
*[[Clofarabine]] | *[[Clofarabine]] | ||
*[[Clofibrate]] | |||
*[[Combined oral contraceptive pill]] | *[[Combined oral contraceptive pill]] | ||
*[[Comfrey]] | *[[Comfrey]] | ||
| Line 208: | Line 228: | ||
*[[Ipilimumab]] | *[[Ipilimumab]] | ||
*[[Isoniazid]] | *[[Isoniazid]] | ||
{{ColBreak}} | |||
*[[Isotretinoin]] | *[[Isotretinoin]] | ||
*[[Kava root extract]] | *[[Kava root extract]] | ||
| Line 218: | Line 239: | ||
*[[Mesalazine]] | *[[Mesalazine]] | ||
*[[Methotrexate]] | *[[Methotrexate]] | ||
*[[Methyldopa]] | *[[Methyldopa]] | ||
*[[Methyldopate]] | *[[Methyldopate]] | ||
| Line 241: | Line 261: | ||
*[[Paclitaxel]] | *[[Paclitaxel]] | ||
*[[Para-amino salicylic acid]] | *[[Para-amino salicylic acid]] | ||
*[[Pazopanib]] | *[[Pazopanib]] | ||
*[[Pegvisomant]] | *[[Pegvisomant]] | ||
| Line 247: | Line 266: | ||
*[[Pentostatin]] | *[[Pentostatin]] | ||
*[[Phenelzine]] | *[[Phenelzine]] | ||
*[[Phenothiazines]] | |||
*[[Phenylbutazone]] | *[[Phenylbutazone]] | ||
*[[Phenytoin]] | *[[Phenytoin]] | ||
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*[[Telithromycin]] | *[[Telithromycin]] | ||
*[[Teriflunomide]] | *[[Teriflunomide]] | ||
*[[Tetracyclines]] | |||
*[[Thiabendazole]] | *[[Thiabendazole]] | ||
*[[Thioguanine]] | *[[Thioguanine]] | ||
| Line 296: | Line 317: | ||
*[[Ximelagatran]] | *[[Ximelagatran]] | ||
*[[Zotepine]] | *[[Zotepine]] | ||
{{EndMultiCol}} | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 20:26, 24 October 2016
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Drug induced liver injury Microchapters |
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Differentiating Drug Induced Liver Injury from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Drug Induced Liver Injury On the Web |
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American Roentgen Ray Society Images of Drug induced liver injury |
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Risk calculators and risk factors for Drug induced liver injury |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rachita Navara, M.D. [2]
Overview
Hundreds of prescription and nonprescription medications as well as supplements have been implicated in drug induced liver injury. A free searchable database of causative agents is available through the National Institute of Health.
Causes
Common Causative Agents:
- Acetaminophen
- Azithromycin
- Ethanol
- Statins
- Tetracycline
- Rosiglitazone
- Amiodarone
- Valproic Acid
- Methotrexate
- Isoniazid
- Rifampin
Causes by Organ System
Causes in Alphabetical Order