Psoriasis laboratory findings: Difference between revisions
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{{Psoriasis}} | |||
{{CMG}}; {{AE}}{{HK}} | |||
{{ | ==Overview== | ||
Laboratory findings consistent with the diagnosis of psoriasis include increased levels of Long Pentraxin 3 protein (PTX3) and elevated [[Complement|complement levels]]. | |||
==Laboratory Findings== | |||
=== Enzyme linked immunosorbent assay (ELISA) === | |||
* In patients with severe psoriasis, increased levels of Long Pentraxin 3 protein (PTX3) can be observed in [[plasma]] and in [[monocytic]] cultures by [[Enzyme linked immunosorbent assay (ELISA)|enzyme linked immunosorbent assay]] (ELISA).<ref name="pmid16865225">{{cite journal |vauthors=Bevelacqua V, Libra M, Mazzarino MC, Gangemi P, Nicotra G, Curatolo S, Massimino D, Plumari A, Merito P, Valente G, Stivala F, La Greca S, Malaponte G |title=Long pentraxin 3: a marker of inflammation in untreated psoriatic patients |journal=Int. J. Mol. Med. |volume=18 |issue=3 |pages=415–23 |year=2006 |pmid=16865225 |doi= |url=}}</ref> | |||
=== Serum complement levels === | |||
The following abnormalities of [[Complement|serum complement]] levels may be observed in cases of psoriasis:<ref name="pmid6159678">{{cite journal |vauthors=Vinje O, Møller P, Mellbye OJ |title=Laboratory findings in patients with psoriasis, with special reference to immunological parameters, associations with arthropathy and sacro-iliitis |journal=Scand. J. Rheumatol. |volume=9 |issue=2 |pages=97–105 |year=1980 |pmid=6159678 |doi= |url=}}</ref> | |||
* Increased serum [[Immunoglobulin A|IgA]] | |||
* Increased [[C3 (complement)|C3]] in phalyngeal [[arthropathy]] associated with psoriasis | |||
* Increased [[Complement|C4]] | |||
* Increased C3PA concentrations | |||
* Increased [[C-reactive protein|CRP]] concentration in [[sacroiliitis]] associated with psoriasis | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
Latest revision as of 23:52, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Laboratory findings consistent with the diagnosis of psoriasis include increased levels of Long Pentraxin 3 protein (PTX3) and elevated complement levels.
Laboratory Findings
Enzyme linked immunosorbent assay (ELISA)
- In patients with severe psoriasis, increased levels of Long Pentraxin 3 protein (PTX3) can be observed in plasma and in monocytic cultures by enzyme linked immunosorbent assay (ELISA).[1]
Serum complement levels
The following abnormalities of serum complement levels may be observed in cases of psoriasis:[2]
- Increased serum IgA
- Increased C3 in phalyngeal arthropathy associated with psoriasis
- Increased C4
- Increased C3PA concentrations
- Increased CRP concentration in sacroiliitis associated with psoriasis
References
- ↑ Bevelacqua V, Libra M, Mazzarino MC, Gangemi P, Nicotra G, Curatolo S, Massimino D, Plumari A, Merito P, Valente G, Stivala F, La Greca S, Malaponte G (2006). "Long pentraxin 3: a marker of inflammation in untreated psoriatic patients". Int. J. Mol. Med. 18 (3): 415–23. PMID 16865225.
- ↑ Vinje O, Møller P, Mellbye OJ (1980). "Laboratory findings in patients with psoriasis, with special reference to immunological parameters, associations with arthropathy and sacro-iliitis". Scand. J. Rheumatol. 9 (2): 97–105. PMID 6159678.