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{{Cataract}}
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==Overview==


==Classification==
==Classification==
 
The classification of cataracts is based on four different criteria.
[[Image:Cataracts due to Congenital Rubella Syndrome (CRS) PHIL 4284 lores.jpg|thumb|250px|left|Bilateral cataracts in an infant due to[[Congenital rubella syndrome]], courtesy CDC]]
# Morphology,
The following is a classification of the various types of cataracts. This is not comprehensive and other unusual types may be noted.
# Age of Onset
:*Classified by etiology
# Maturity
:*Age-related cataract
# Etiology
::*Immature Senile Cataract (IMSC) - partially opaque lens, [[Optic disc|disc]] view hazy
# Location of opacity
::*Mature Senile Cataract (MSC) - Completely opaque lens, no disc view
{| class="wikitable"
::*Hypermature Senile Cataract (HMSC) - Liquefied cortical matter: '''Morgagnian Cataract'''
!
:*Congenital cataract
!Sub-types
::*Sutural cataract
!
::*Lamellar cataract
|-
::*Zonular cataract
|Morphology
::*Total cataract
|
::* Secondary cataract
* Capsular
[[Image:Anterior capsular opacification.jpg|thumb|250px|left|[[Slit lamp]] photo of Anterior capsular opacification visible a few months after implantation of Intraocular lens in eye, magnified view]]
* Subcapsular
::*Drug-induced cataract (e.g. Corticosteroids)
* Nuclear
:*Traumatic cataract
* Corical
::*Blunt trauma (capsule usually intact)
* Lamellar
::*Penetrating trauma (capsular rupture & leakage of lens material - calls for an emergency surgery for extraction of lens and leaked material to minimize further damage)
* Sutural
 
|
*Classified by location of opacity within lens structure (However, mixed morphology is quite commonly seen, e.g. PSC with nuclear changes & cortical spokes of cataract)
* '''Capsular '''
:*Anterior cortical cataract
# Congenital capsular thickening-  Associated with posterior or anterior polar cataracts and pyramidal cataract. The posterior form may be associated with a hyaloid remnant.
:*Anterior polar cataract
# Acquired capsular opacities - Occur with pseudoexfoliation, Infra-red radiation (Glass blower’s cataract) or Secondary to blunt trauma when a Vossius’ ring may be formed. 
:*Anterior subcapsular cataract
* '''Subcapsular '''
[[Image:Posterior capsular opacification on retroillumination.jpg|thumb|left|250px|[[Slit lamp]] photo of Posterior capsular opacification visible a few months after implantation of Intraocular lens in eye, seen on retroillumination]]
# Posterior subcapsular - Lens changes may be associated with secondary or complicated cataracts, drugs e.g., steroids, or be an age-related cataract (Cupuliform). 
 
# Anterior subcapsular''' '''  Anterior subcapsular lens changes may be associated with   Wilson’s disease (sunflower cataract) or with drugs e.g., amiodarone
:*Nuclear cataract - Grading correlates with hardness & difficulty of surgical removal
* '''Nuclear '''
::*1 - Grey
# Congenital - Nuclear cataract is that secondary to Rubella 
::*2 - Yellow
# Age-related - Nuclear sclerosis cataract commonly seen in practice is the age-related form.  
::*3 - Amber
* '''Cortical '''
::*4 - Brown/Black (Note: "Black cataract" translated in some languages (like Hindi) refers to [[Glaucoma]], not the color of the lens nucleus)
# Congenital - Congenital cortical cataract is very common and they rarely interfere with vision. e.g., blue dot cataract and coronary cataract.
:*Posterior cortical cataract
# Age-related - Known as cuneiform cataract that takes the form of “water” clefts and vacuoles. These often appear first in the inferior nasal quadrant of the lens possibly because this is most exposed to UV radiation. 
:*Posterior polar cataract (importance lies in higher risk of complication - posterior capsular tears during surgery)
* '''Lamellar '''
:*Posterior subcapsular cataract (PSC) (clinically common)
# Congenital - The cataracts are usually congenital and often involve one lamella of the fetal or nuclear zones. Radial, spoke-like opacities (or riders) also often surround the cataract. 
::*After-cataract - posterior capsular opacification subsequent to  a successful extracapsular cataract surgery (usually within 3 months - 2 years) with or without IOL implantation. Requires a quick & painless office procedure with [[Nd:YAG laser]] capsulotomy to restore optical clarity.
* '''Sutural '''
# These are often known as “Y”-shaped” cataract
|-
|Maturity
|
*Immature Senile Cataract (IMSC) - partially opaque lens, [[Optic disc|disc]] view hazy
*Mature Senile Cataract (MSC) - Completely opaque lens, no disc view
*Hypermature Senile Cataract (HMSC) - Liquefied cortical matter: '''Morgagnian Cataract'''
*Congenital cataract
|
* '''Immature or incomplete -''' The cataract is present but not visually incapacitating. Surgery may or may not be indicated. 
* '''Mature -''' The whole lens is opaque. Surgery is usually indicated. 
* '''Intumescent -''' The lens is swollen. Surgery is indicated. 
* '''Hypermature -''' The lens is shrunken, yellow and the capsule is wrinkled. 
* '''Morganian cataract -''' A hypermature cataract with liquified cortex and in which the nucleus settles inferiorly. 
|-
|Location of opacity 
|
:* Anterior cortical cataract
:* Anterior polar cataract
:* Anterior subcapsular cataract
:* Nuclear cataract
:* Posterior cortical cataract
:* Posterior polar cataract (importance lies in higher risk of complication - posterior capsular tears during surgery)
:* Posterior subcapsular cataract (PSC) (clinically common)
|
* Anterior subcapsular lens changes may be associated with Wilson’s disease (sunflower cataract) or with drugs e.g., amiodarone
* Posterior subcapsular cataract changes may associated with secondary or complicated cataracts, drugs e.g., steroids, or be an age related cataract.
|-
|Etiological
|
* Congenital 
* Degenerative or “age related” (senile) 
* Traumatic 
* Secondary to other conditions (including metabolic causes) 
* Toxic 
* Hereditary 
|
* '''Congenital cataract''' - Result of heredity (often autosomal dominant), prenatal infections such as rubella or metabolic disorders. 
*# Intrauterine infections e.g. [[Congenital rubella syndrome|Rubella]] and [[Toxoplasmosis congenital|Toxoplasmosis]]. 
*# Maternal drug ingestion e.g. [[Thalidomide]] and corticosteroids. 
*# Genetically transmitted syndromes 
*# [[Microphthalmia|Microphthalmos]]
*# Ocular conditions with associated anomalies e.g. [[Retinopathy of Prematurity]] and some types of retinitis pigmentosa. 
*# Secondary to metabolic disorders e.g. [[Galactosemia]] and [[Wilson's disease|Wilson’s disease]]  
* '''Degenerative or "Age-Related" (senile)'''- Most adults have some degree of opacification of the lens and therefore technically exhibit cataract. 
*# Subcapsular Anterior subcapsular cataract (directly under the capsule) is associated with fibrous metaplasia of anterior lens epithelium. Posterior subcapsular cataract (cupuliform) lies just in front of the posterior capsule and is associated with posterior migration of epithelial cells. 
*# Cortical cataract commonly develops as radial or spoke-shaped “water-clefts” (cuneiform) together with vacuoles. Cuneiform changes affect anterior, posterior and equatorial cortex affected.
*# Nuclear sclerosis  Nuclear cataract is an exacerbation of the normal aging of lens nucleus and appears as a yellowing of the nucleus. 
*'''Traumatic''' - Trauma is the commonest cause of unilateral cataract in young individuals. Opacities can be the result of various injuries including penetrating injury. Concussion to the eye may cause the iris to be flattened against the lens leaving a Vossius’ ring. 
*'''Secondary''' - Cataract can occur secondary to systemic disease or syndromes including metabolic disorders and due to local disease (ocular).  
**Secondary to systemic diseases/metabolic disorders
**#Diabetes - Diabetes mellitus can cause an exacerbation of the progression of age-related degenerative changes. So-called (classical) diabetic cataract occurs during an acute and untreated hyperglycaemic episode and takes the form of cortical “snowflakes”. These occur due to osmotic over-hydration of the lens and can be anterior and/or posterior in position. 
**#Galactosaemia - This metabolic disease produces an “oil droplet” cataract
**#Wilson’s disease (hepatolenticular degeneration) - This is an anomaly of copper metabolism and produces a ring of copper in the peripheral cornea (Kayser-Fleischer ring) and a greenish colored “sunflower cataract” 
**#Atopic dermatitis - Cataract can occur secondary to atopic dermatitis and takes the form of bilateral posterior or anterior stellate opacities. 
**#Down’s syndrome - 15% of Down’s have lens opacities severe enough to cause a decrease in acuity (Kanski, 1998) and with a reported prevalence of up to 50% (Scully, 1973).  
**Secondary to local disease (or complicated cataract) 
**#Anterior uveitis - Anterior uveitis can produce a posterior polar polychromatic cataract. Also, if uveitis not controlled, anterior and posterior subcapsular opacities can progress to complete opacification. 
**#High myopia - Hight myopia can be associated with secondary posterior lens opacities as well as the earlier development of nuclear sclerosis. 
**#Glaukomflecken - These are grey-white anterior capsular or subcapsular opacities in pupillary zone pathognomonic with previous attacks of acute angle-closure glaucoma. 
*'''Toxic '''
*#Corticosteroids - Steroids used for prolonged therapy produce a posterior subcapsular cataract
*#Amiodarone - Amiodarone can cause anterior capsular changes in up to 50% of patients. The opacities tend to be visually insignificant. 
|}
::


==References==
==References==
{{reflist|2}}
{{reflist|2}}
{{WS}}
{{WH}}


[[Category:Aging-associated diseases]]
[[Category:Blindness]]
[[Category:Ophthalmology]]
[[Category:Ophthalmology]]
[[Category:Optometry]]
[[Category:Disease]]
[[Category:Primary care]]
[[Category:Needs overview]]

Latest revision as of 20:49, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Rohan Bir Singh, M.B.B.S.[2]

Overview

Classification

The classification of cataracts is based on four different criteria.

  1. Morphology,
  2. Age of Onset
  3. Maturity
  4. Etiology
  5. Location of opacity
Sub-types
Morphology
  • Capsular
  • Subcapsular
  • Nuclear
  • Corical
  • Lamellar
  • Sutural
  • Capsular 
  1. Congenital capsular thickening- Associated with posterior or anterior polar cataracts and pyramidal cataract. The posterior form may be associated with a hyaloid remnant.
  2. Acquired capsular opacities - Occur with pseudoexfoliation, Infra-red radiation (Glass blower’s cataract) or Secondary to blunt trauma when a Vossius’ ring may be formed. 
  • Subcapsular 
  1. Posterior subcapsular - Lens changes may be associated with secondary or complicated cataracts, drugs e.g., steroids, or be an age-related cataract (Cupuliform). 
  2. Anterior subcapsular  Anterior subcapsular lens changes may be associated with  Wilson’s disease (sunflower cataract) or with drugs e.g., amiodarone
  • Nuclear 
  1. Congenital - Nuclear cataract is that secondary to Rubella 
  2. Age-related - Nuclear sclerosis cataract commonly seen in practice is the age-related form.  
  • Cortical 
  1. Congenital - Congenital cortical cataract is very common and they rarely interfere with vision. e.g., blue dot cataract and coronary cataract.
  2. Age-related - Known as cuneiform cataract that takes the form of “water” clefts and vacuoles. These often appear first in the inferior nasal quadrant of the lens possibly because this is most exposed to UV radiation. 
  • Lamellar 
  1. Congenital - The cataracts are usually congenital and often involve one lamella of the fetal or nuclear zones. Radial, spoke-like opacities (or riders) also often surround the cataract. 
  • Sutural 
  1. These are often known as “Y”-shaped” cataract. 
Maturity
  • Immature Senile Cataract (IMSC) - partially opaque lens, disc view hazy
  • Mature Senile Cataract (MSC) - Completely opaque lens, no disc view
  • Hypermature Senile Cataract (HMSC) - Liquefied cortical matter: Morgagnian Cataract
  • Congenital cataract
  • Immature or incomplete - The cataract is present but not visually incapacitating. Surgery may or may not be indicated. 
  • Mature - The whole lens is opaque. Surgery is usually indicated. 
  • Intumescent - The lens is swollen. Surgery is indicated. 
  • Hypermature - The lens is shrunken, yellow and the capsule is wrinkled. 
  • Morganian cataract - A hypermature cataract with liquified cortex and in which the nucleus settles inferiorly. 
Location of opacity
  • Anterior cortical cataract
  • Anterior polar cataract
  • Anterior subcapsular cataract
  • Nuclear cataract
  • Posterior cortical cataract
  • Posterior polar cataract (importance lies in higher risk of complication - posterior capsular tears during surgery)
  • Posterior subcapsular cataract (PSC) (clinically common)
  • Anterior subcapsular lens changes may be associated with Wilson’s disease (sunflower cataract) or with drugs e.g., amiodarone
  • Posterior subcapsular cataract changes may associated with secondary or complicated cataracts, drugs e.g., steroids, or be an age related cataract.
Etiological
  • Congenital 
  • Degenerative or “age related” (senile) 
  • Traumatic 
  • Secondary to other conditions (including metabolic causes) 
  • Toxic 
  • Hereditary 
  • Congenital cataract - Result of heredity (often autosomal dominant), prenatal infections such as rubella or metabolic disorders. 
    1. Intrauterine infections e.g. Rubella and Toxoplasmosis
    2. Maternal drug ingestion e.g. Thalidomide and corticosteroids. 
    3. Genetically transmitted syndromes 
    4. Microphthalmos
    5. Ocular conditions with associated anomalies e.g. Retinopathy of Prematurity and some types of retinitis pigmentosa. 
    6. Secondary to metabolic disorders e.g. Galactosemia and Wilson’s disease
  • Degenerative or "Age-Related" (senile)- Most adults have some degree of opacification of the lens and therefore technically exhibit cataract. 
    1. Subcapsular Anterior subcapsular cataract (directly under the capsule) is associated with fibrous metaplasia of anterior lens epithelium. Posterior subcapsular cataract (cupuliform) lies just in front of the posterior capsule and is associated with posterior migration of epithelial cells. 
    2. Cortical cataract commonly develops as radial or spoke-shaped “water-clefts” (cuneiform) together with vacuoles. Cuneiform changes affect anterior, posterior and equatorial cortex affected.
    3. Nuclear sclerosis  Nuclear cataract is an exacerbation of the normal aging of lens nucleus and appears as a yellowing of the nucleus. 
  • Traumatic - Trauma is the commonest cause of unilateral cataract in young individuals. Opacities can be the result of various injuries including penetrating injury. Concussion to the eye may cause the iris to be flattened against the lens leaving a Vossius’ ring. 
  • Secondary - Cataract can occur secondary to systemic disease or syndromes including metabolic disorders and due to local disease (ocular). 
    • Secondary to systemic diseases/metabolic disorders
      1. Diabetes - Diabetes mellitus can cause an exacerbation of the progression of age-related degenerative changes. So-called (classical) diabetic cataract occurs during an acute and untreated hyperglycaemic episode and takes the form of cortical “snowflakes”. These occur due to osmotic over-hydration of the lens and can be anterior and/or posterior in position. 
      2. Galactosaemia - This metabolic disease produces an “oil droplet” cataract. 
      3. Wilson’s disease (hepatolenticular degeneration) - This is an anomaly of copper metabolism and produces a ring of copper in the peripheral cornea (Kayser-Fleischer ring) and a greenish colored “sunflower cataract” 
      4. Atopic dermatitis - Cataract can occur secondary to atopic dermatitis and takes the form of bilateral posterior or anterior stellate opacities. 
      5. Down’s syndrome - 15% of Down’s have lens opacities severe enough to cause a decrease in acuity (Kanski, 1998) and with a reported prevalence of up to 50% (Scully, 1973). 
    • Secondary to local disease (or complicated cataract) 
      1. Anterior uveitis - Anterior uveitis can produce a posterior polar polychromatic cataract. Also, if uveitis not controlled, anterior and posterior subcapsular opacities can progress to complete opacification. 
      2. High myopia - Hight myopia can be associated with secondary posterior lens opacities as well as the earlier development of nuclear sclerosis. 
      3. Glaukomflecken - These are grey-white anterior capsular or subcapsular opacities in pupillary zone pathognomonic with previous attacks of acute angle-closure glaucoma. 
  • Toxic 
    1. Corticosteroids - Steroids used for prolonged therapy produce a posterior subcapsular cataract. 
    2. Amiodarone - Amiodarone can cause anterior capsular changes in up to 50% of patients. The opacities tend to be visually insignificant. 

References

Template:WS Template:WH