Cardiac amyloidosis history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Amyloidosis is a multi-system disease involving many organs simultaneously. Approximately | Amyloidosis is a multi-system disease involving many [[Organ (biology)|organs]] simultaneously. Approximately 50% of the [[Patient|patients]] with cardiac amyloidosis present with [[right heart failure]] [[symptoms]]. The most common [[symptoms]] observed in [[patients]] with cardiac amyloidosis include [[fatigue]], [[weight loss]], and [[purpura|periorbital purpura]]. | ||
==Symptoms== | ==History and Symptoms== | ||
Cardiac | |||
*[[Congestive heart failure]] such as | === History === | ||
** [[Fatigue]] | |||
** [[Dyspnea]] | * [[Patient|Patients]] with cardiac amyloidosis present with [[Medical sign|signs]] and [[Symptom|symptoms]] of [[Congestive heart failure|heart failure]]. | ||
** [[Dizziness]] | |||
** [[Orthopnea]]<ref name="pmid7878478">{{cite journal |author=Kyle RA, Gertz MA |title=Primary systemic amyloidosis: clinical and laboratory features in 474 cases |journal=[[Seminars in Hematology]] |volume=32 |issue=1 |pages=45–59 |year=1995 |month=January |pmid=7878478 |doi= |url= |accessdate=2012-02-13}}</ref> | === Symptoms === | ||
** [[Peripheral edema]] | Cardiac amyloidosis can be associated with the following [[Symptom|symptoms]]:<ref name="pmid9578896">{{cite journal |author=Dubrey SW, Cha K, Anderson J, ''et al.'' |title=The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement |journal=[[QJM : Monthly Journal of the Association of Physicians]] |volume=91 |issue=2 |pages=141–57 |year=1998 |month=February |pmid=9578896 |doi= |url=}}</ref> | ||
** [[Weight loss]] due to cardiac cachexia | |||
** [[Ascites]] | *[[Congestive heart failure]] with associated symptoms such as | ||
*[[arrhythmia|Arrhythmias]] such as [[Palpitation|palpitations]] | **[[Fatigue]] | ||
* [[Syncope]] and [[presyncope]] | **[[Dyspnea]] | ||
*[[Postural hypotension]] may be observed in patients with subendothelial amyloid deposition.<ref name="pmid17062380">{{cite journal |author=Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A |title=Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies? |journal=[[Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis]] |volume=13 |issue=3 |pages=143–53 |year=2006 |month=September |pmid=17062380 |doi=10.1080/13506120600877136 |url=http://informahealthcare.com/doi/abs/10.1080/13506120600877136 |accessdate=2012-02-13}}</ref> | **[[Dizziness]] | ||
* [[Chest pain]] or chest discomfort <ref name="pmid10974179">{{cite journal |author=Mueller PS, Edwards WD, Gertz MA |title=Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis |journal=[[The American Journal of Medicine]] |volume=109 |issue=3 |pages=181–8 |year=2000 |month=August |pmid=10974179 |doi= |url=}}</ref><ref name="pmid10610629">{{cite journal |author=Al Suwaidi J, Velianou JL, Gertz MA, ''et al.'' |title=Systemic amyloidosis presenting with angina pectoris |journal=[[Annals of Internal Medicine]] |volume=131 |issue=11 |pages=838–41 |year=1999 |month=December |pmid=10610629 |doi= |url=}}</ref> | **[[Orthopnea]]<ref name="pmid7878478">{{cite journal |author=Kyle RA, Gertz MA |title=Primary systemic amyloidosis: clinical and laboratory features in 474 cases |journal=[[Seminars in Hematology]] |volume=32 |issue=1 |pages=45–59 |year=1995 |month=January |pmid=7878478 |doi= |url= |accessdate=2012-02-13}}</ref> | ||
**[[Peripheral edema]] | |||
**[[Weight loss]] due to [[cardiac cachexia]] | |||
**[[Ascites]] | |||
*[[arrhythmia|Arrhythmias]] with associated symptoms such as [[Palpitation|palpitations]] | |||
*[[Syncope]] and [[presyncope]] | |||
**[[Syncope]] on exertion is an ominous sign of cardiac amyloidosis, as these [[Patient|patients]] cannot augment their [[cardiac output]] due to poor filling of the [[ventricle]] ([[restrictive cardiomyopathy]]).<ref name="pmid21747665">{{cite journal |author=Mugnai G, Cicoira M, Rossi A, Vassanelli C |title=Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report |journal=[[Experimental and Clinical Cardiology]] |volume=16 |issue=2 |pages=51–3 |year=2011 |pmid=21747665 |pmc=3126684 |doi= |url=}}</ref> | |||
*[[Postural hypotension]] may be observed in [[Patient|patients]] with subendothelial amyloid deposition.<ref name="pmid17062380">{{cite journal |author=Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A |title=Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies? |journal=[[Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis]] |volume=13 |issue=3 |pages=143–53 |year=2006 |month=September |pmid=17062380 |doi=10.1080/13506120600877136 |url=http://informahealthcare.com/doi/abs/10.1080/13506120600877136 |accessdate=2012-02-13}}</ref> | |||
*[[Chest pain]] or [[chest discomfort]] <ref name="pmid10974179">{{cite journal |author=Mueller PS, Edwards WD, Gertz MA |title=Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis |journal=[[The American Journal of Medicine]] |volume=109 |issue=3 |pages=181–8 |year=2000 |month=August |pmid=10974179 |doi= |url=}}</ref><ref name="pmid10610629">{{cite journal |author=Al Suwaidi J, Velianou JL, Gertz MA, ''et al.'' |title=Systemic amyloidosis presenting with angina pectoris |journal=[[Annals of Internal Medicine]] |volume=131 |issue=11 |pages=838–41 |year=1999 |month=December |pmid=10610629 |doi= |url=}}</ref> | |||
* Non-specific symptoms like: | * Non-specific symptoms like: | ||
** [[Poor appetite]] | **[[purpura|Periorbital purpura]] | ||
** [[Weight loss]] | **[[Poor appetite]] | ||
** [[Early satiety]] | **[[Weight loss]] | ||
**[[Early satiety]] | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Aarti Narayan, M.B.B.S [3]; Cafer Zorkun, M.D., Ph.D. [4]; Lakshmi Gopalakrishnan, M.B.B.S. [5]
Overview
Amyloidosis is a multi-system disease involving many organs simultaneously. Approximately 50% of the patients with cardiac amyloidosis present with right heart failure symptoms. The most common symptoms observed in patients with cardiac amyloidosis include fatigue, weight loss, and periorbital purpura.
History and Symptoms
History
- Patients with cardiac amyloidosis present with signs and symptoms of heart failure.
Symptoms
Cardiac amyloidosis can be associated with the following symptoms:[1]
- Congestive heart failure with associated symptoms such as
- Arrhythmias with associated symptoms such as palpitations
- Syncope and presyncope
- Syncope on exertion is an ominous sign of cardiac amyloidosis, as these patients cannot augment their cardiac output due to poor filling of the ventricle (restrictive cardiomyopathy).[3]
- Postural hypotension may be observed in patients with subendothelial amyloid deposition.[4]
- Chest pain or chest discomfort [5][6]
- Non-specific symptoms like:
References
- ↑ Dubrey SW, Cha K, Anderson J; et al. (1998). "The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement". QJM : Monthly Journal of the Association of Physicians. 91 (2): 141–57. PMID 9578896. Unknown parameter
|month=ignored (help) - ↑ Kyle RA, Gertz MA (1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Seminars in Hematology. 32 (1): 45–59. PMID 7878478. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Mugnai G, Cicoira M, Rossi A, Vassanelli C (2011). "Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report". Experimental and Clinical Cardiology. 16 (2): 51–3. PMC 3126684. PMID 21747665.
- ↑ Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A (2006). "Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies?". Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13 (3): 143–53. doi:10.1080/13506120600877136. PMID 17062380. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help) - ↑ Mueller PS, Edwards WD, Gertz MA (2000). "Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis". The American Journal of Medicine. 109 (3): 181–8. PMID 10974179. Unknown parameter
|month=ignored (help) - ↑ Al Suwaidi J, Velianou JL, Gertz MA; et al. (1999). "Systemic amyloidosis presenting with angina pectoris". Annals of Internal Medicine. 131 (11): 838–41. PMID 10610629. Unknown parameter
|month=ignored (help)