Linear atrophoderma of Moulin: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
This disease was first referred to as Atrophoderma of Moulin after Dr.Moulin who first reported it in 1992<ref name="pmid1296472">{{cite journal | author = Moulin G, Hill MP, Guillaud V, Barrut D, Chevallier J, Thomas L | title = [Acquired atrophic pigmented band-like lesions following Blaschko's lines] | language = French | journal = [[Annales de dermatologie et de vénéréologie]] | volume = 119 | issue = 10 | pages = 729–36 | year = 1992 | pmid = 1296472 | doi = | url = | issn = }}</ref> then was renamed as linear atrophoderma of Moulin.<ref name="pmid8014049">{{cite journal | author = Baumann L, Happle R, Plewig G, Schirren CG | title = [Atrophodermia linearis Moulin. A new disease picture, following the Blaschko lines] | language = German | journal = [[Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, Und Verwandte Gebiete]] | volume = 45 | issue = 4 | pages = 231–6 | year = 1994 | month = April | pmid = 8014049 | doi = | url = | issn = }}</ref> | This disease was first referred to as Atrophoderma of Moulin after Dr. Moulin who first reported it in 1992<ref name="pmid1296472">{{cite journal | author = Moulin G, Hill MP, Guillaud V, Barrut D, Chevallier J, Thomas L | title = [Acquired atrophic pigmented band-like lesions following Blaschko's lines] | language = French | journal = [[Annales de dermatologie et de vénéréologie]] | volume = 119 | issue = 10 | pages = 729–36 | year = 1992 | pmid = 1296472 | doi = | url = | issn = }}</ref> then was renamed as linear atrophoderma of Moulin.<ref name="pmid8014049">{{cite journal | author = Baumann L, Happle R, Plewig G, Schirren CG | title = [Atrophodermia linearis Moulin. A new disease picture, following the Blaschko lines] | language = German | journal = [[Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, Und Verwandte Gebiete]] | volume = 45 | issue = 4 | pages = 231–6 | year = 1994 | month = April | pmid = 8014049 | doi = | url = | issn = }}</ref> | ||
==Pathophysiology== | ==Pathophysiology== | ||
LAM is a [[cutaneous]] form of [[mosaicism]] <ref name="pmid12963915">{{cite journal | author = Danarti R, Bittar M, Happle R, König A | title = Linear atrophoderma of Moulin: postulation of mosaicism for a predisposing gene | journal = [[Journal of the American Academy of Dermatology]] | volume = 49 | issue = 3 | pages = 492–8 | year = 2003 | month = September | pmid = 12963915 | doi = 10.1067/S0190-9622(03)00895-8| url = http://linkinghub.elsevier.com/retrieve/pii/S0190962203008958 | issn = }}</ref> | LAM is a [[cutaneous]] form of [[mosaicism]].<ref name="pmid12963915">{{cite journal | author = Danarti R, Bittar M, Happle R, König A | title = Linear atrophoderma of Moulin: postulation of mosaicism for a predisposing gene | journal = [[Journal of the American Academy of Dermatology]] | volume = 49 | issue = 3 | pages = 492–8 | year = 2003 | month = September | pmid = 12963915 | doi = 10.1067/S0190-9622(03)00895-8| url = http://linkinghub.elsevier.com/retrieve/pii/S0190962203008958 | issn = }}</ref> | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Only a few dozen cases of LAM have been described.<ref name="pmid16207193">{{cite journal | author = Miteva L, Nikolova K, Obreshkova E | title = Linear atrophoderma of Moulin | journal = [[International Journal of Dermatology]] | volume = 44 | issue = 10 | pages = 867–9 | year = 2005 | month = October | pmid = 16207193 | doi = 10.1111/j.1365-4632.2004.02221.x | url = http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=2005&volume=44&issue=10&spage=867 | issn = }}</ref><ref name="pmid18086596">{{cite journal | author = Zampetti A, Antuzzi D, Caldarola G, Celleno L, Amerio P, Feliciani C | title = Linear atrophoderma of Moulin | journal = [[European Journal of Dermatology]] | volume = 18 | issue = 1 | pages = 79–80 | year = 2008 | pmid = 18086596 | doi = 10.1684/ejd.2007.0316 | url = http://www.john-libbey-eurotext.fr/medline.md?issn=1167-1122&vol=18&iss=1&page=79 | issn = }}</ref><ref name="pmid18713593">{{cite journal | author = Cecchi R, Bartoli L, Brunetti L, Pavesi M | title = Linear atrophoderma of Moulin localized to the neck | journal = [[Dermatology Online Journal]] | volume = 14 | issue = 6 | pages = 12 | year = 2008 | pmid = 18713593 | doi = | url = | issn = }}</ref> | Only a few dozen cases of LAM have been described.<ref name="pmid16207193">{{cite journal | author = Miteva L, Nikolova K, Obreshkova E | title = Linear atrophoderma of Moulin | journal = [[International Journal of Dermatology]] | volume = 44 | issue = 10 | pages = 867–9 | year = 2005 | month = October | pmid = 16207193 | doi = 10.1111/j.1365-4632.2004.02221.x | url = http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=2005&volume=44&issue=10&spage=867 | issn = }}</ref><ref name="pmid18086596">{{cite journal | author = Zampetti A, Antuzzi D, Caldarola G, Celleno L, Amerio P, Feliciani C | title = Linear atrophoderma of Moulin | journal = [[European Journal of Dermatology]] | volume = 18 | issue = 1 | pages = 79–80 | year = 2008 | pmid = 18086596 | doi = 10.1684/ejd.2007.0316 | url = http://www.john-libbey-eurotext.fr/medline.md?issn=1167-1122&vol=18&iss=1&page=79 | issn = }}</ref><ref name="pmid18713593">{{cite journal | author = Cecchi R, Bartoli L, Brunetti L, Pavesi M | title = Linear atrophoderma of Moulin localized to the neck | journal = [[Dermatology Online Journal]] | volume = 14 | issue = 6 | pages = 12 | year = 2008 | pmid = 18713593 | doi = | url = | issn = }}</ref> LAM affects [[children]] or [[adolescents]] of both genders. | ||
==Natural History, Complications, Prognosis== | ==Natural History, Complications, Prognosis== | ||
Latest revision as of 21:49, 29 July 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Atrophodermia linearis Moulin; LAM; Moulin disease
Overview
Linear atrophoderma of Moulin (LAM) is an acquired unilateral hyperpigmented dermatitis localized along the Blaschko's lines.
Historical Perspective
This disease was first referred to as Atrophoderma of Moulin after Dr. Moulin who first reported it in 1992[1] then was renamed as linear atrophoderma of Moulin.[2]
Pathophysiology
LAM is a cutaneous form of mosaicism.[3]
Differential Diagnosis
The LAM must be distinguished from other linear dermatoses:
- Blaschkitis acuta
- Epidermal naevi
- Inflammatory linear verrucous epidermal naevus
- Lichen striatus
- Linear lupus erythematosus
- Linear scleroderma
- Reticulate hyperpigmentation of Iijima
Epidemiology and Demographics
Only a few dozen cases of LAM have been described.[4][5][6] LAM affects children or adolescents of both genders.
Natural History, Complications, Prognosis
Natural History
There is neither preceding inflammation, nor later induration or scleroderma.
Complications
The condition can be disfiguring and lead to emotional distress.
Prognosis
The prognosis is good.
Diagnosis
Physcial Examination
Skin
- The rash generally involves the trunk and limbs.
Laboratory Studies
The clinical diagnosis is supported by micropatholgy.
Treatment
Intravenous penicillin G administered for 14 days in a dosage of 10 x 106 IU twice daily has been prescribed in the past.[7]
References
- ↑ Moulin G, Hill MP, Guillaud V, Barrut D, Chevallier J, Thomas L (1992). "[Acquired atrophic pigmented band-like lesions following Blaschko's lines]". Annales de dermatologie et de vénéréologie (in French). 119 (10): 729–36. PMID 1296472.
- ↑ Baumann L, Happle R, Plewig G, Schirren CG (1994). "[Atrophodermia linearis Moulin. A new disease picture, following the Blaschko lines]". Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, Und Verwandte Gebiete (in German). 45 (4): 231–6. PMID 8014049. Unknown parameter
|month=ignored (help) - ↑ Danarti R, Bittar M, Happle R, König A (2003). "Linear atrophoderma of Moulin: postulation of mosaicism for a predisposing gene". Journal of the American Academy of Dermatology. 49 (3): 492–8. doi:10.1067/S0190-9622(03)00895-8. PMID 12963915. Unknown parameter
|month=ignored (help) - ↑ Miteva L, Nikolova K, Obreshkova E (2005). "Linear atrophoderma of Moulin". International Journal of Dermatology. 44 (10): 867–9. doi:10.1111/j.1365-4632.2004.02221.x. PMID 16207193. Unknown parameter
|month=ignored (help) - ↑ Zampetti A, Antuzzi D, Caldarola G, Celleno L, Amerio P, Feliciani C (2008). "Linear atrophoderma of Moulin". European Journal of Dermatology. 18 (1): 79–80. doi:10.1684/ejd.2007.0316. PMID 18086596.
- ↑ Cecchi R, Bartoli L, Brunetti L, Pavesi M (2008). "Linear atrophoderma of Moulin localized to the neck". Dermatology Online Journal. 14 (6): 12. PMID 18713593.
- ↑ Rompel, R.; Mischke, AL.; Langner, C.; Happle, R. (2000). "Linear atrophoderma of Moulin". Eur J Dermatol. 10 (8): 611–3. PMID 11125323. Unknown parameter
|month=ignored (help)