First degree AV block causes: Difference between revisions

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==Overview==
==Overview==
An atrioventricular block (or AV block) is a type of [[heart block]] involving an impairment of the conduction between the [[atria]] and [[ventricles]] of the heart.<ref>{{Dorlands|b_16|12188991}}</ref>  It usually involves the [[atrioventricular node]], but it can involve other structures too. AV block is categorized by degree and site of conduction block.  In first-degree AV block, all atrial impulses are conducted to the ventricles; however, there is a delay in conduction within the [[AV node]] resulting in a [[prolonged PR interval]] on [[ECG]] (>200 msec or >5 small blocks). In other words, first degree block is a slowed conduction without loss of atrioventricular synchrony.
Common causes of [[first-degree AV block]] include [[ischemic heart disease]], [[congenital heart disease]], [[electrolyte]] abnormalities (particularly [[hypokalemia]] and [[hypomagnesemia]]), [[inflammation]], [[infections]] ([[endocarditis]], [[rheumatic fever]], [[Chagas disease]], [[Lyme disease]], [[diphtheria]]), [[drugs]] ([[antiarrhythmic ]] Ia, Ic, II, III, IV and [[digoxin]], [[β-blockers]], [[calcium channel blockers]] ), [[infiltrative diseases]] ([[sarcoidosis]]), [[collagen vascular diseases]] ([[SLE]], [[rheumatoid arthritis]], [[scleroderma]]), idiopathic degenerative diseases ([[Lenegre]] and [[Lev diseases]]) and [[neuromuscular disorders]] and increased [[vagal tone]] in younger [[patients]].


==Causes==
==Causes==
===Life Threatening Causes===
===Life Threatening Causes===
Life-threatening conditions can result in death or permanent disability within 24 hours if left untreated.
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
* [[Acute myocardial infarction]]
*[[Acute myocardial infarction]]
* [[Acute rheumatic fever]]
*[[Acute rheumatic fever]]
* [[Bacterial endocarditis]]
*[[Bacterial endocarditis]]
* [[Myocarditis]]
*[[Myocarditis]]


===Common Causes===
===Common Causes===
* [[Hyperkalemia]]
*[[Hyperkalemia]]
* [[Hyperthyroidism]]
*[[Hyperthyroidism]]
* [[vagus nerve|Increased vagal tone]] (e.g. [[sleep]], athletes)
*[[Hypothyroidism]]
* [[Ischemic heart disease]]
*[[vagus nerve|Increased vagal tone]] (e.g. [[sleep]], athletes)
* Medications ( e.g. [[adenosine]], [[amiodarone]], [[beta-blockers]], [[diltiazem]], [[procainamide]], [[verapamil]])
*[[Ischemic heart disease]]
*Medications ( e.g. [[adenosine]], [[amiodarone]], [[beta-blockers]], [[diltiazem]], [[procainamide]], [[verapamil]])


===Causes by Organ System===
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" |[[Acute myocardial infarction]], [[acute rheumatic fever]], [[ASD]], [[dilated cardiomyopathy]],  [[Ebstein's anomaly]], [[Carotid sinus hypersensitivity|hypersensitive carotid sinus syndrome]], [[hypertension]], [[hypertrophic cardiomyopathy]], idiopathic bilateral bundle  branch fibrosis, idiopathic progressive  cardiac conduction disease, [[Lev's disease]], [[myocardial bridging]], [[myocarditis]], [[Aortic valve  replacement|post aortic valve  replacement]], [[catheter ablation|post catheter ablation for arrhythmias]], [[ventricular septal defect surgery|post closure of a ventricular septal defect]], [[mitral valve replacement|post mitral valve replacement]], [[tetralogy of Fallot]], [[endocardial cushion defect]], [[transposition of the great vessels]],  [[valvular heart disease]], [[VSD]]
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Acute myocardial infarction]], [[acute rheumatic fever]], [[ASD]], [[dilated cardiomyopathy]],  [[Ebstein's anomaly]], [[Carotid sinus hypersensitivity|hypersensitive carotid sinus syndrome]], [[hypertension]], [[hypertrophic cardiomyopathy]], [[Lev's disease]], [[myocardial bridging]], [[myocarditis]], [[Aortic valve  replacement|post aortic valve  replacement]], [[catheter ablation|post catheter ablation for arrhythmias]], [[ventricular septal defect surgery|post closure of a ventricular septal defect]], [[mitral valve replacement|post mitral valve replacement]], [[tetralogy of Fallot]], [[endocardial cushion defect]], [[transposition of the great vessels]],  [[valvular heart disease]], [[VSD]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Amiodarone]], [[beta-blockers]], [[digitalis]], [[calcium channel blockers]], [[cholinesterase inhibitor|cholinesterase inhibitors]], [[disopyramide]], [[dofetilide]], [[dolasetron]], [[donepezil]], [[eslicarbazepine acetate]], [[fesoterodine]], [[fingolimod]], [[flecainide]], [[ibutilide]], [[lacosamide]], [[magnesium]], [[paliperidone]], [[procainamide]], [[propafenone]], [[propoxyphene]], [[quinidine]], [[sotalol]], [[terodiline]]
|bgcolor="Beige"| [[Amiodarone]], [[beta-blockers]], [[digitalis]], [[calcium channel blockers]], [[cholinesterase inhibitor|cholinesterase inhibitors]], [[disopyramide]], [[dofetilide]], [[dolasetron]], [[donepezil]], [[eslicarbazepine acetate]], [[fesoterodine]], [[fingolimod]], [[flecainide]], [[ibutilide]], [[lacosamide]], [[magnesium]], [[paliperidone]], [[pramipexole]], [[procainamide]], [[propafenone]], [[propoxyphene]], [[quinidine]], [[sotalol]], [[terodiline]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| [[Hyperthyroidism]], [[myxedema]], [[periodic  paralysis|thyrotoxic periodic paralysis]]
|bgcolor="Beige"| [[Hyperthyroidism]], [[myxedema]], [[periodic  paralysis|thyrotoxic periodic paralysis]], [[hypothyroidism]]
|-  
|-  
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| [[Emery-Dreifuss muscular dystrophy]], [[Fabry disease]], [[glycogenosis type 2b]], hereditary neuromuscular neurodegenerative disease, [[Kearns-Sayre syndrome]]
|bgcolor="Beige"| [[Emery-Dreifuss muscular dystrophy]], [[Fabry disease]], [[glycogenosis type 2b]], [[Neuromuscular disease|hereditary neuromuscular disease]], [[Kearns-Sayre syndrome]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| [[Acute rheumatic fever]], [[Chagas disease]], [[diphtheria]], [[Lyme disease]], [[myocarditis]], neonatal lupus syndrome, [[protozoa|protozoal infection]], [[sarcoidosis]], [[SLE]], [[tuberculosis]]
|bgcolor="Beige"| [[Acute rheumatic fever]], [[Chagas disease]], [[diphtheria]], [[Lyme disease]], [[myocarditis]], [[neonatal lupus erythematosus]], [[protozoa|protozoal infection]], [[sarcoidosis]], [[SLE]], [[tuberculosis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal / Ortho'''
| '''Musculoskeletal / Ortho'''
|bgcolor="Beige"| [[Ankylosing spondylitis]], hereditary neuromuscular heredodegenerative disease, [[Kearns-Sayre syndrome]], [[mitochondrial DNA|mitochondrial genome inherited conditions]],  [[muscular dystrophy]]
|bgcolor="Beige"| [[Ankylosing spondylitis]], [[Neuromuscular disease|hereditary neuromuscular disease]], [[Kearns-Sayre syndrome]], [[mitochondrial disease|mitochondrial genome inherited conditions]],  [[muscular dystrophy]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"|  [[Amyloidosis]], [[degenerative diseases]], enhanced [[vagus nerve|vagal tone]] (for example in athletes), normal variants, [[pain]], [[sleep ]], [[trauma]]
|bgcolor="Beige"|  [[Amyloidosis]], [[degenerative diseases]], [[vagus nerve|enhanced  vagal tone]], [[PR interval|normal variants]]
|-
|-
|}
|}
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{{col-begin|width=80%}}
{{col-begin|width=80%}}
{{col-break|width=33%}}
{{col-break|width=33%}}
* [[Acute myocardial infarction]]
*[[Acute myocardial infarction]]
 
*[[Acute rheumatic fever]]
* [[Acute rheumatic fever]]
*[[Amyloidosis]]
 
*[[Ankylosing spondylitis]]
* [[Amyloidosis]]
*[[ASD]]
 
*[[Bacterial endocarditis]]
* [[Ankylosing spondylitis]]
*[[Beta-blockers]]
 
*[[Calcific aortic stenosis]]
* [[ASD]]
*[[Calcium channel blockers]]
 
*[[Cardiac glycosides]]
* [[Bacterial endocarditis]]
*[[Cardiac tumors]]
 
*[[Chagas disease]]
* [[Beta-blockers]]
*[[Cholinesterase inhibitors]]
 
*[[Clonidine]]
* [[Calcific aortic stenosis]]
*[[Degenerative diseases]]
 
*[[Dermatomyositis]]
* [[Calcium channel blockers]]
*[[Digitalis]]
 
*[[Digoxin]]
* [[Cardiac glycosides]]
*[[Dilated cardiomyopathy]]
 
*[[Diltiazem]]
* [[Cardiac tumors]]
*[[Diphtheria]]
 
*[[Disopyramide]]
* [[Chagas disease]]
*[[Dolasetron]]
 
*[[Donepezil]]
* [[Cholinesterase inhibitors]]
*[[Ebstein anomaly]]
 
*[[Ebstein's anomaly]]
* [[Clonidine]]
*[[Electrolyte disturbances]]
 
*[[Emery-Dreifuss muscular dystrophy]]
* [[Degenerative diseases]]
*[[vagus nerve|Enhanced vagal tone in athletes]]  
 
* [[Dermatomyositis]]
 
* [[Digitalis]]
 
* [[Digoxin]]
 
* [[Dilated cardiomyopathy]]
 
* [[Diltiazem]]
 
* [[Diphtheria]]
 
* [[Disopyramide]]
 
* [[Dolasetron]]
 
* [[Donepezil]]
 
* [[Drugs]]
 
* [[Ebstein anomaly]]
 
* [[Ebstein's anomaly]]
 
* [[Electrolyte disturbances]]
 
* [[Emery-Dreifuss muscular dystrophy]], [[sex linkage|x-linked]]
 
* [[Endocarditis]]
 
* [[vagus nerve|enhanced vagal tone in athletes]]
 
* [[Eslicarbazepine acetate]]
{{col-break|width=33%}}
{{col-break|width=33%}}
 
*[[Eslicarbazepine acetate]]
* [[Fabry disease]]
*[[Fabry disease]]
 
*[[Fesoterodine]]
* [[Fesoterodine]]
*[[Fingolimod]]
 
*[[Glycogenosis type 2b]]
* [[Fingolimod]]
*[[HCM]]
 
* [[Neuromuscular disease|Hereditary neuromuscular disease]]
* [[Glycogenosis type 2b]]
*[[Hodgkin lymphoma]]
 
*[[Hyperkalaemia]]
* [[HCM]]
*[[Carotid sinus hypersensitivity|Hypersensitive carotid sinus syndrome]]
 
*[[Hyperthyroidism]]
* [[Neuromuscular disease|hereditary neuromuscular disease]]
*[[Hypokalaemia]]
 
*[[Hypothermia]]
* [[Hodgkin lymphoma]]
*[[Ibutilide]]
 
*[[Ischaemic heart disease]]
* [[Hyperkalaemia]]
*[[Kearns-Sayre syndrome]]
 
*[[Labetalol]]
* [[Carotid sinus hypersensitivity|Hypersensitive carotid sinus syndrome]]
*[[Lacosamide]]
 
*[[Lanatoside C]]
* [[Hyperthyroidism]]
*[[Lenegre's disease]]
 
*[[Lev's disease]]
* [[Hypokalaemia]]
*[[Lyme disease]]
 
*[[Mitochondrial DNA|Mitochondrial genome inherited conditions]]
* [[Hypothermia]]
*[[Multiple myeloma]]
 
*[[Muscular dystrophy]]
* [[Ibutilide]]
*[[Myocardial bridging]]
 
*[[Myocarditis]]
* [[Ischaemic heart disease]]
*[[Myotonic dystrophy]]
 
*[[Myxedema]]
* [[Kearns-Sayre syndrome]]
 
* [[Labetalol]]
 
* [[Lacosamide]]
 
* [[Lanatoside C]]
 
* [[Lenegre's disease]]
 
* [[Lev's disease]]
 
* [[Lyme disease]]
 
* [[Mitochondrial DNA|Mitochondrial genome inherited conditions]]
 
* [[Multiple myeloma]]
 
* [[Muscular dystrophy]]
 
* [[Myocardial bridging]]
 
* [[Myocarditis]]
 
* [[Myotonic dystrophy]]
 
* [[Myxedema]]
 
* [[neonatal lupus erythrematosus]]
 
* [[prolonged PR interval|Normal variants of PR  prolongation]]
 
* [[Pain]]
 
* [[Paliperidone]]
{{col-break|width=33%}}
{{col-break|width=33%}}
 
*[[Neonatal lupus erythematosus]]
* [[aortic valve  replacement|Post aortic valve replacement ]]
*[[prolonged PR interval|Normal variants of PR  prolongation]]
 
*[[Paliperidone]]
* [[catheter ablation|Post catheter ablation for  arrhythmias]]
*[[aortic valve  replacement|Post aortic valve replacement ]]
 
*[[catheter ablation|Post catheter ablation for  arrhythmias]]
* [[Ventricular septal defect surgery|Post closure of a  ventricular septal defect]]
*[[Ventricular septal defect surgery|Post closure of a  ventricular septal defect]]
 
*[[mitral valve  replacement|Post mitral valve  replacement]]
* [[mitral valve  replacement|Post mitral valve  replacement]]
*[[Procainamide]]
 
*[[Propoxyphene]]
* [[Procainamide ]]
*[[Propranolol]]
 
*[[Protozoa|Protozoal infection]]
* [[Propoxyphene]]
*[[Quinidine]]
 
*[[Quinine]]
* [[Propranolol]]
*[[Rheumatic fever|Rheumatic mitral valve disease]]
 
*[[Sarcoidosis]]
* [[Protozoa|Protozoal infection]]
*[[SLE]]
 
*[[Systemic sclerosis]]
* [[Quinidine]]
*[[Terodiline]]
 
*[[Tetralogy of Fallot]]
* [[Quinine]]
*[[periodic  paralysis|Thyrotoxic periodic  paralysis]]
 
*[[Tolterodine]]
* [[Rheumatic fever|Rheumatic mitral valve disease]]
*[[Transposition of the great  vessels]]
 
*[[vagus nerve|Vagal maneuvers]]
* [[Sarcoidosis]]
*[[Valsalva maneuver]]
 
*[[Valvular heart disease]]
* [[SLE]]
*[[Verapamil]]
 
*[[VSD]]
* [[Sleep ]]
*[[sex linkage|X-linked inherited  conditions]]
 
* [[Systemic sclerosis]]
 
* [[Terodiline]]
 
* [[Tetralogy of fallot]]
 
* [[periodic  paralysis|Thyrotoxic periodic  paralysis]]
 
* [[Tolterodine]]
 
* [[Transposition of the great  vessels]]
 
* [[Trauma]]
 
* [[vagus nerve|Vagal maneuvers]]
 
* [[Valsalva manouevre]]
 
* [[Valvular heart disease]]
 
* [[Verapamil]]
 
* [[VSD]]
 
* [[sex linkage|X-linked inherited  conditions]]
{{col-end}}
{{col-end}}


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{{Reflist|2}}
{{Reflist|2}}


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Latest revision as of 04:51, 22 July 2021

First degree AV block Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Raviteja Guddeti, M.B.B.S. [3]

Overview

Common causes of first-degree AV block include ischemic heart disease, congenital heart disease, electrolyte abnormalities (particularly hypokalemia and hypomagnesemia), inflammation, infections (endocarditis, rheumatic fever, Chagas disease, Lyme disease, diphtheria), drugs (antiarrhythmic Ia, Ic, II, III, IV and digoxin, β-blockers, calcium channel blockers ), infiltrative diseases (sarcoidosis), collagen vascular diseases (SLE, rheumatoid arthritis, scleroderma), idiopathic degenerative diseases (Lenegre and Lev diseases) and neuromuscular disorders and increased vagal tone in younger patients.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular Acute myocardial infarction, acute rheumatic fever, ASD, dilated cardiomyopathy, Ebstein's anomaly, hypersensitive carotid sinus syndrome, hypertension, hypertrophic cardiomyopathy, Lev's disease, myocardial bridging, myocarditis, post aortic valve replacement, post catheter ablation for arrhythmias, post closure of a ventricular septal defect, post mitral valve replacement, tetralogy of Fallot, endocardial cushion defect, transposition of the great vessels, valvular heart disease, VSD
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect Amiodarone, beta-blockers, digitalis, calcium channel blockers, cholinesterase inhibitors, disopyramide, dofetilide, dolasetron, donepezil, eslicarbazepine acetate, fesoterodine, fingolimod, flecainide, ibutilide, lacosamide, magnesium, paliperidone, pramipexole, procainamide, propafenone, propoxyphene, quinidine, sotalol, terodiline
Ear Nose Throat No underlying causes
Endocrine Hyperthyroidism, myxedema, thyrotoxic periodic paralysis, hypothyroidism
Environmental Hypothermia
Gastroenterologic Hemochromatosis
Genetic Emery-Dreifuss muscular dystrophy, Fabry disease, glycogenosis type 2b, hereditary neuromuscular disease, Kearns-Sayre syndrome
Hematologic Multiple myeloma
Iatrogenic Post aortic valve replacement, post catheter ablation for arrhythmias, post closure of a ventricular septal defect, post mitral valve replacement
Infectious Disease Acute rheumatic fever, Chagas disease, diphtheria, Lyme disease, myocarditis, neonatal lupus erythematosus, protozoal infection, sarcoidosis, SLE, tuberculosis
Musculoskeletal / Ortho Ankylosing spondylitis, hereditary neuromuscular disease, Kearns-Sayre syndrome, mitochondrial genome inherited conditions, muscular dystrophy
Neurologic No underlying causes
Nutritional / Metabolic Fabry disease, glycogenosis type 2b
Obstetric/Gynecologic No underlying causes
Oncologic Multiple myeloma
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Sarcoidosis
Renal / Electrolyte Hyperkalemia, hypokalemia
Rheum / Immune / Allergy Ankylosing spondylitis, dermatomyositis, rheumatoid arthritis, scleroderma, SLE
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Amyloidosis, degenerative diseases, enhanced vagal tone, normal variants

Causes in Alphabetical Order

References


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