WBR0386

Author	[[PageAuthor::Yazan Daaboul, M.D. (Reviewed by Yazan Daaboul, M.D.)]]
Exam Type	ExamType::USMLE Step 1
Main Category	MainCategory::Embryology
Sub Category	SubCategory::Renal
Prompt	[[Prompt::A researcher discovers developmental inhibitors of embryological components that help him study embryologic origins of various human tissues. In one experiment, the researcher decides to inhibit the development of the ureteric bud. As a result of his experiment, which of the following nephron structures will fail to develop?]]
Answer A	AnswerA::Glomeruli
Answer A Explanation	AnswerAExp::The glomerulus is derived from the metanephros.
Answer B	AnswerB::Cortical proximal convoluted tubule (PCT)
Answer B Explanation	AnswerBExp::The proximal convoluted tubule is derived from the metanephros.
Answer C	AnswerC::Loop of Henle in the medulla
Answer C Explanation	AnswerCExp::Loop of Henle is derived from the metanephros.
Answer D	AnswerD::Cortical distal convoluted tubules
Answer D Explanation	AnswerDExp::The distal convoluted tubules are derived from the metanephros.
Answer E	AnswerE::Medullary collecting ducts
Answer E Explanation	AnswerEExp::Collecting ducts are derived from the ureteric bud.
Right Answer	RightAnswer::E
Explanation	[[Explanation::The ureteric bud is derived from the caudal end of the mesonephros. It gives rise to the collecting ducts, the renal pelvicalyceal system, and the ureters. In contrast, the metanephros, which interacts with the ureteric bud, gives rise to renal structures, such as the glomerulus, proximal convoluted tubules, loop of Henle, and the distal convoluted tubules. Educational Objective: The metanephros and ureteric bud interact to give rise to the renal and urinary structures. The metanephros gives rise to the glomerulus through the distal convoluted tubule, while the ureteric bud gives rise to the collecting duct, pelvicalyceal system, and the ureters. References: First Aid 2014 page 522]]
Approved	Approved::Yes
Keyword	WBRKeyword::Ureteric bud, WBRKeyword::Kidney embryology, WBRKeyword::Metanephros, WBRKeyword::Metanephric mesenchyme, WBRKeyword::Collecting ducts, WBRKeyword::Experiment, WBRKeyword::Developmental inhibitor, WBRKeyword::Nephron
Linked Question	Linked::
Order in Linked Questions	LinkedOrder::