Sandbox/68

Tissue	Cell type	Functions
Adipose tissue	Adipose-associated macrophages	Control of insulin sensitivity and adaptive thermogenesis
Blood	Ly-6Clo monocytes	Function analogously as intravascular housekeepers, clearing endothelial cell debris
Bone	Osteoclasts Bone marrow macrophages	Multinucleated cells formed by fusion that resorb bone by disruption of the mineralized matrix Support erythropoeisis and maintain hematopoietic stem cells in stem cell niches"
Central nervous system	"Microglia
Perivascular macrophages
Meningeal macrophages"	"Promote neuronal survival and are involved in frontline immune surveillance, removal of dead neurons and synaptic remodelling; derived from yolk sac and maintained in adult and during inflammation independently of the bone marrow
Immune surveillance
Immune surveillance"
Gastrointestinal tract	Intestinal macrophages	Maintenance of intestinal homeostasis and regulation of immune responses to commensals; monocyte-derived
Liver	"Kupffer cells (sessile)
Motile liver macrophages"	"Clearance of microorganisms and cell debris from the blood, and clearance of aged erythrocytes; prenatal origins; maintained in the adult independently of the bone marrow
Immune surveillance"
Lung	"Alveolar macrophages
Interstitial macrophages"	"Immune surveillance of the lung for inhaled pathogens and clearance of surfactant; prenatal origins; maintained in adult and during inflammation independently of the bone marrow
Regulates DC maturation and/or activation"
Serosal tissues	"Peritoneal macrophages
Pleural macrophages"	"Immune surveillance and regulation of homeostatic environment; apoptotic cell clearance; prenatal origins; maintained in adult and during inflammation independently of the bone marrow
Immune surveillance; maintained in adult and can expand during TH2 cell inflammation independently of the bone marrow"
Skin	"Dermal macrophages
Langerhans cells"	"Immune surveillance
Interaction with T lymphocytes; derived from yolk sac and/or fetal liver and maintained independently of the bone marrow"
Spleen	"Marginal zone macrophages
Metallophilic macrophages
Red pulp macrophages
White pulp (tingible body) macrophages"	"Immune surveillance of the circulation
Immune surveillance
Erythrocyte clearance and iron metabolism; prenatal origins; maintained in adult independently of the bone marrow
Clearance of apoptotic cells resulting during the germinal center reaction"