Ampicillin Trihydrate: Difference between revisions

Latest revision as of 23:16, 30 December 2013

Ampicillin Trihydrate
AMPICILLIN capsule^® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family and is roughly equivalent to its successor, amoxicillin in terms of spectrum and level of activity. It can sometimes result in reactions that range in severity from a rash (in the case of patients who may unwittingly have mononucleosis) to potentially lethal allergic reactions such as anaphylaxis. However, as with other penicillin drugs, it is relatively nontoxic, and adverse effects of a serious nature are encountered only rarely.

US Brand Names

AMPICILLIN capsule^® [Sandoz Inc]

FDA Package Insert

Mechanism of Action

Belonging to the penicillins group of beta-lactam antibiotics, ampicillin is able to penetrate Gram-positive and some Gram-negative bacteria. It differs from penicillin only by the presence of an amino group. The amino group helps the drug penetrate the outer membrane of gram-negative bacteria. Ampicillin acts as a competitive inhibitor of the enzyme transpeptidase. Transpeptidase is needed by bacteria to make their cell walls. It inhibits the third and final stage of bacterial cell wall synthesis, which ultimately leads to cell lysis

References

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 {{CMG}}; {{AE}} {{MM}}
 ==Overview==
-'''Ampicillin''' is a [[beta-lactam antibiotic|beta-lactam]] [[antibiotic]] that is part of the [[aminopenicillin]] family and is roughly equivalent to its successor, [[amoxicillin]] in terms of spectrum and level of activity.<ref name=AHFS>{{cite book | title= AHFS DRUG INFORMATION 2006 | publisher= American Society of Health-System Pharmacists | year= 2006 | edition= 2006}}</ref> It can sometimes result in reactions that range in severity from a [[rash]] (in the case of patients who may unwittingly have [[Infectious mononucleosis|mononucleosis]]) to potentially lethal [[allergic reaction]]s such as [[anaphylaxis]]. However, as with other penicillin drugs, it is relatively nontoxic, and adverse effects of a serious nature are encountered only rarely.
+'''Ampicillin''' is a [[beta-lactam antibiotic|beta-lactam]] [[antibiotic]] that is part of the aminopenicillin family and is roughly equivalent to its successor, [[amoxicillin]] in terms of spectrum and level of activity. It can sometimes result in reactions that range in severity from a [[rash]] (in the case of patients who may unwittingly have [[Infectious mononucleosis|mononucleosis]]) to potentially lethal [[allergic reaction]]s such as [[anaphylaxis]]. However, as with other penicillin drugs, it is relatively nontoxic, and adverse effects of a serious nature are encountered only rarely.
 ==Category==
+[[beta-lactam antibiotic]]
 ==US Brand Names==
@@ Line 12: / Line 13: @@
 ==FDA Package Insert==
-'''[[XXXXX description|Description]]'''
+'''[[Ampicillin Trihydrate description|Description]]'''
-'''| [[XXXXX clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Ampicillin Trihydrate clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[XXXXX microbiology|Microbiology]]'''
+'''| [[Ampicillin Trihydrate microbiology|Microbiology]]'''
-'''| [[XXXXX indications and usage|Indications and Usage]]'''
+'''| [[Ampicillin Trihydrate indications and usage|Indications and Usage]]'''
-'''| [[XXXXX contraindications|Contraindications]]'''
+'''| [[Ampicillin Trihydrate contraindications|Contraindications]]'''
-'''| [[XXXXX warnings and precautions|Warnings and Precautions]]'''
+'''| [[Ampicillin Trihydrate warnings and precautions|Warnings and Precautions]]'''
-'''| [[XXXXX adverse reactions|Adverse Reactions]]'''
+'''| [[Ampicillin Trihydrate adverse reactions|Adverse Reactions]]'''
-'''| [[XXXXX overdosage|Overdosage]]'''
+'''| [[Ampicillin Trihydrate overdosage|Overdosage]]'''
-'''| [[XXXXX clinical studies|Clinical Studies]]'''
+'''| [[Ampicillin Trihydrate dosage and administration|Dosage and Administration]]'''
-'''| [[XXXXX dosage and administration|Dosage and Administration]]'''
+'''| [[Ampicillin Trihydrate how supplied|How Supplied]]'''
-'''| [[XXXXX compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]'''
+'''| [[Ampicillin Trihydrate labels and packages|Labels and Packages]]'''
-'''| [[XXXXX directions for use|Directions For Use]]'''
-'''| [[XXXXX how supplied|How Supplied]]'''
-'''| [[XXXXX labels and packages|Labels and Packages]]'''
 ==Mechanism of Action==
+Belonging to the [[penicillins]] group of beta-lactam antibiotics, ampicillin is able to penetrate [[Gram-positive]] and some [[Gram-negative]] bacteria. It differs from penicillin only by the presence of an [[amino]] group. The amino group helps the drug penetrate the outer membrane of gram-negative bacteria. Ampicillin acts as a competitive inhibitor of the enzyme transpeptidase. Transpeptidase is needed by bacteria to make their cell walls. It inhibits the third and final stage of bacterial [[cell wall]] synthesis, which ultimately leads to cell [[lysis]]
 ==References==