Dehydroemetine dosage and administration: Difference between revisions
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==Dosage and Administration== | |||
Injections should always be given intramuscularly. Intravenous injection is unacceptably dangerous and holds no advantage. At least 6 weeks should elapse before a second course is administered. | |||
In amebic dysentery, supplementary treatment with tetracycline reduces the risk of bacterial superinfection. | |||
<ref>{{Cite web | last = | first = | title = WHO Model Prescribing Information: Drugs Used in Parasitic Diseases - Second Edition: Protozoa: Amoebiasis and giardiasis: Dehydroemetine | url = http://apps.who.int/medicinedocs/en/d/Jh2922e/2.1.3.html#Jh2922e.2.1.3 | publisher = | date = | accessdate = }}</ref> | In hepatic abscess, supplementary treatment with chloroquine, which is selectively concentrated in the liver, may be given orally, either concurrently or immediately afterwards. | ||
All patients should subsequently receive diloxanide by mouth to eliminate surviving organisms in the colon.<ref>{{Cite web | last = | first = | title = WHO Model Prescribing Information: Drugs Used in Parasitic Diseases - Second Edition: Protozoa: Amoebiasis and giardiasis: Dehydroemetine | url =http://apps.who.int/medicinedocs/en/d/Jh2922e/2.1.3.html#Jh2922e.2.1.3 | publisher = | date = | accessdate = }}</ref> | |||
====Adults==== | |||
1 mg/kg daily, to a maximum of 60 mg, for up to 4-6 days. This dosage should be reduced by up to 50% in elderly and severely ill patients. | |||
====Children==== | |||
1 mg/kg daily for no more than 5 days. | |||
==References== | ==References== | ||
Latest revision as of 00:36, 31 December 2013
| Dehydroemetine |
|---|
| MEBADIN® Prescribing Information |
| General Information |
| Clinical Information |
| Dosage and Administration |
| Precautions |
| Use in Pregnancy |
| Adverse Effects |
| Drug Interactions |
| Storage |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Dosage and Administration
Injections should always be given intramuscularly. Intravenous injection is unacceptably dangerous and holds no advantage. At least 6 weeks should elapse before a second course is administered.
In amebic dysentery, supplementary treatment with tetracycline reduces the risk of bacterial superinfection.
In hepatic abscess, supplementary treatment with chloroquine, which is selectively concentrated in the liver, may be given orally, either concurrently or immediately afterwards.
All patients should subsequently receive diloxanide by mouth to eliminate surviving organisms in the colon.[1]
Adults
1 mg/kg daily, to a maximum of 60 mg, for up to 4-6 days. This dosage should be reduced by up to 50% in elderly and severely ill patients.
Children
1 mg/kg daily for no more than 5 days.