Loracarbef: Difference between revisions
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{{Drugbox | {{Drugbox | ||
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| verifiedrevid = 462093698 | | verifiedrevid = 462093698 | ||
| IUPAC_name = (6''R'',7''S'')-7-<nowiki>[[</nowiki>(2''S'')-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | | IUPAC_name = (6''R'',7''S'')-7-<nowiki>[[</nowiki>(2''S'')-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | ||
| image = Loracarbef.png | | image =Loracarbef.png | ||
<!--Clinical data--> | <!--Clinical data--> | ||
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__NOTOC__ | __NOTOC__ | ||
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{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
Loracarbef is a synthetic [[carbacephem]] antibiotic.<ref name="pmid8150976">{{cite journal |author=Biedenbach DJ, Jones RN |title=Predictive accuracy of disk diffusion test for Proteus vulgaris and Providencia species against five newer orally administered cephalosporins, cefdinir, cefetamet, cefprozil, cefuroxime, and loracarbef |journal=J. Clin. Microbiol. |volume=32 |issue=2|pages=559–62 |year=1994 |month=February |pmid=8150976 |pmc=263078 |doi= |url=http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=8150976}}</ref> Loracarbef has a spectrum of activity similar to that of the second generation [[cephalosporin]]s. It is an analogue of [[cefaclor]] from which the [[sulfur]] atom is replaced with a [[methylene]] group. Therefore loracarbef has a greater stability in solution and may be stored at room temperature. | Loracarbef is a synthetic [[carbacephem]] antibiotic.<ref name="pmid8150976">{{cite journal |author=Biedenbach DJ, Jones RN |title=Predictive accuracy of disk diffusion test for Proteus vulgaris and Providencia species against five newer orally administered cephalosporins, cefdinir, cefetamet, cefprozil, cefuroxime, and loracarbef |journal=J. Clin. Microbiol. |volume=32 |issue=2|pages=559–62 |year=1994 |month=February |pmid=8150976 |pmc=263078 |doi= |url=http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=8150976}}</ref> Loracarbef has a spectrum of activity similar to that of the second generation [[cephalosporin]]s. It is an analogue of [[cefaclor]] from which the [[sulfur]] atom is replaced with a [[methylene]] group. Therefore loracarbef has a greater stability in solution and may be stored at room temperature. | ||
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==Category== | ==Category== | ||
Carbacephem | Carbacephem | ||
== | ==Brand Names== | ||
LORABID<sup>®</sup> | |||
LORABID<sup>®</sup> (''DISCONTINUED'') | |||
==Mechanism of Action== | ==Mechanism of Action== | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Antibiotics]] | [[Category:Antibiotics]] | ||
[[Category: | [[Category:Drug]] | ||
Latest revision as of 16:37, 20 August 2015
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| Clinical data | |
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| Trade names | Lorabid |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601206 |
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| Protein binding | 25% |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C16H16ClN3O4 |
| Molar mass | 349.769 g/mol |
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Patient resources on Loracarbef Discussion groups on Loracarbef Patient Handouts on Loracarbef Directions to Hospitals Treating Loracarbef Risk calculators and risk factors for Loracarbef
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Loracarbef is a synthetic carbacephem antibiotic.[1] Loracarbef has a spectrum of activity similar to that of the second generation cephalosporins. It is an analogue of cefaclor from which the sulfur atom is replaced with a methylene group. Therefore loracarbef has a greater stability in solution and may be stored at room temperature.
Diarrhea is the most common adverse effect. Side effects are more frequently seen with children under the age of twelve. It received FDA approval in 1991. Its use was discontinued in 2006.
Category
Carbacephem
Brand Names
LORABID® (DISCONTINUED)
Mechanism of Action
Loracarbef is an oral, synthetic beta-lactam antibiotic of the carbacephem class. Loracarbef, like all beta-lactams and cephalosporins, inhibits penicillin binding proteins, enzymes that create the cross-linkage of the peptidoglycan polymer. This binding leads to interference with the formation and remodeling of the cell wall structure.
References
- ↑ Biedenbach DJ, Jones RN (1994). "Predictive accuracy of disk diffusion test for Proteus vulgaris and Providencia species against five newer orally administered cephalosporins, cefdinir, cefetamet, cefprozil, cefuroxime, and loracarbef". J. Clin. Microbiol. 32 (2): 559–62. PMC 263078. PMID 8150976. Unknown parameter
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