Etravirine overdosage: Difference between revisions
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==Overdosage== | |||
There is no specific antidote for overdose with INTELENCE<sup>®</sup>. Human experience of overdose with INTELENCE<sup>®</sup> is limited. The highest dose studied in healthy volunteers was 400 mg once daily. Treatment of overdose with INTELENCE® consists of general supportive measures including monitoring of vital signs and observation of the clinical status of the patient. If indicated, elimination of unabsorbed active substance is to be achieved by [[emesis]] or [[gastric lavage]]. Administration of [[activated charcoal]] may also be used to aid in removal of unabsorbed active substance. Because etravirine is highly protein bound, [[dialysis]] is unlikely to result in significant removal of the active substance.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = INTELENCE (ETRAVIRINE) TABLET [JANSSEN PRODUCTS LP] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6a9cbc29-9f15-4b24-8d86-206b82887f3d | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 17:05, 5 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Overdosage
There is no specific antidote for overdose with INTELENCE®. Human experience of overdose with INTELENCE® is limited. The highest dose studied in healthy volunteers was 400 mg once daily. Treatment of overdose with INTELENCE® consists of general supportive measures including monitoring of vital signs and observation of the clinical status of the patient. If indicated, elimination of unabsorbed active substance is to be achieved by emesis or gastric lavage. Administration of activated charcoal may also be used to aid in removal of unabsorbed active substance. Because etravirine is highly protein bound, dialysis is unlikely to result in significant removal of the active substance.[1]
References
Adapted from the FDA Package Insert.