Penicillin G sodium: Difference between revisions
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==Overview== | ==Overview== | ||
Penicillin G sodium, a water soluble benzylpenicillin,itis bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. Penicillin G is typically given [[parenteral|parenterally]], bypassing the intestines, because it is unstable in the highly acidic stomach. Because the drug is given parenterally, higher tissue concentrations of penicillin G can be achieved than is possible with phenoxymethylpenicillin. These higher concentrations translate to increased antibacterial activity. | |||
==Category== | ==Category== | ||
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==US Brand Names== | ==US Brand Names== | ||
PENICILLIN G SODIUM | PENICILLIN G SODIUM<sup>®</sup> | ||
==FDA Package Insert== | ==FDA Package Insert== | ||
Latest revision as of 06:45, 4 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Overview
Penicillin G sodium, a water soluble benzylpenicillin,itis bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. Penicillin G is typically given parenterally, bypassing the intestines, because it is unstable in the highly acidic stomach. Because the drug is given parenterally, higher tissue concentrations of penicillin G can be achieved than is possible with phenoxymethylpenicillin. These higher concentrations translate to increased antibacterial activity.
Category
Penicillinase-resistant penicillins
US Brand Names
PENICILLIN G SODIUM®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable resulting in death of the bacterium.