Penicillin G sodium drug interactions: Difference between revisions
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Penicillin blood levels may be prolonged by concurrent administration of probenecid which blocks the renal tubular secretion of penicillins. | Penicillin blood levels may be prolonged by concurrent administration of probenecid which blocks the renal tubular secretion of penicillins. | ||
Other drugs may compete with Penicillin G for renal tubular secretion and thus prolong the serum half-life of penicillin. These drugs include: [[aspirin]], [[phenylbutazone]], [[sulfonamide]]s, [[indomethacin]], [[thiazide diuretics]], [[furosemide]] and [[ethacrynic acid]]. | Other drugs may compete with Penicillin G for renal tubular secretion and thus prolong the serum half-life of penicillin. These drugs include: [[aspirin]], [[phenylbutazone]], [[sulfonamide]]s, [[indomethacin]], [[thiazide diuretics]], [[furosemide]] and [[ethacrynic acid]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = PENICILLIN G SODIUM INJECTION, POWDER, FOR SOLUTION [SANDOZ INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=23b6d4a3-b273-4e10-9da9-1376933fdbdf | publisher = | date = | accessdate}}</ref> | ||
==References== | |||
{{Reflist}} | |||
{{FDA}} | |||
[[Category:Antibiotics]] | |||
[[Category:Wikinfect]] | |||
Latest revision as of 06:03, 4 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Drug Interactions
Bacteriostatic antibacterials (i.e., chloramphenicol, erythromycins, sulfonamides or tetracyclines) may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. This has been documented in vitro, however, the clinical significance of this interaction is not well-documented.
Penicillin blood levels may be prolonged by concurrent administration of probenecid which blocks the renal tubular secretion of penicillins.
Other drugs may compete with Penicillin G for renal tubular secretion and thus prolong the serum half-life of penicillin. These drugs include: aspirin, phenylbutazone, sulfonamides, indomethacin, thiazide diuretics, furosemide and ethacrynic acid.[1]
References
- ↑ "PENICILLIN G SODIUM INJECTION, POWDER, FOR SOLUTION [SANDOZ INC]". Text " accessdate" ignored (help)
Adapted from the FDA Package Insert.