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| __NOTOC__
| | #REDIRECT [[Amoxicillin-Clavulanate]] |
| {{Amoxicillin-clavulanate potassium}}
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| {{CMG}}; {{AE}} {{MM}}
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| ==Overview==
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| '''Amoxicillin/clavulanic acid''' ([[International Nonproprietary Name|INN]]) or '''co-amoxiclav''' ([[British Approved Name|BAN]]) is a combination [[antibiotic]] consisting of [[amoxicillin]] trihydrate, a [[β-lactam antibiotic]], and [[potassium clavulanate]], a β-lactamase inhibitor. This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce β-lactamase.
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| Unlike [[co-trimoxazole]], the BAN has not been widely adopted internationally. Trade names include '''Augmentin''' (by [[GlaxoSmithKline]]),<ref name="BNF">{{cite book |title=[[British National Formulary]] |edition=57 |date=March 2009}}</ref> '''Clavamox''' (by [[Pfizer]]), '''Tyclav''' (by Beximco Pharma), and many others.
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| ==Category==
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| [[beta-lactam antibiotic]]s
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| ==US Brand Names==
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| AUGMENTIN<sup>®</sup>
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| ==FDA Package Insert==
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| '''[[Amoxicillin-clavulanate potassium description|Description]]'''
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| '''| [[Amoxicillin-clavulanate potassium clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Amoxicillin-clavulanate potassium microbiology|Microbiology]]'''
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| '''| [[Amoxicillin-clavulanate potassium indications and usage|Indications and Usage]]'''
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| '''| [[Amoxicillin-clavulanate potassium contraindications|Contraindications]]'''
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| '''| [[Amoxicillin-clavulanate potassium warnings and precautions|Warnings and Precautions]]'''
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| '''| [[Amoxicillin-clavulanate potassium adverse reactions|Adverse Reactions]]'''
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| '''| [[Amoxicillin-clavulanate potassium drug interactions|Drug Interactions]]'''
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| '''| [[Amoxicillin-clavulanate potassium overdosage|Overdosage]]'''
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| '''| [[Amoxicillin-clavulanate potassium dosage and administration|Dosage and Administration]]'''
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| '''| [[Amoxicillin-clavulanate potassium how supplied|How Supplied]]'''
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| ==Mechanism of Action==
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| Amoxicillin is a semisynthetic antibiotic with in vitro bactericidal activity against Gram-positive and Gram-negative bacteria. Amoxicillin is, however, susceptible to degradation by beta-lactamases, and therefore, the spectrum of activity does not include organisms which produce these enzymes. Clavulanic acid is a beta-lactam, structurally related to the penicillins, which possesses the ability to inactivate some beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmid-mediated beta-lactamases frequently responsible for transferred drug resistance.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = AUGMENTIN (AMOXICILLIN AND CLAVULANATE POTASSIUM) TABLET, FILM COATED AUGMENTIN (AMOXICILLIN AND CLAVULANATE POTASSIUM) POWDER, FOR SUSPENSION [DR. REDDY'S LABORATORIES INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=174cc098-fe49-4f1a-87e2-601c7573f0db | publisher = | date = | accessdate}}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antibiotics]]
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| [[Category:Wikinfect]]
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