Halofantrine drug interactions: Difference between revisions
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==Drug Interactions== | |||
Although no drug interaction studies have been conducted, Halfan should not be administered with drugs known to prolong the QTc interval. In clinical use, an interaction with mefloquine has been reported to lead to further prolongation of the QTc interval.1 The prolongation may be significant and potentially fatal; therefore, Halfan should not be given simultaneously with or subsequent to mefloquine. There have been no drug interactions reported when halofantrine is coadministered with chloroquine. | |||
In vitro studies have shown that drugs which inhibit cytochrome [[CYP3A4]], e.g., [[ketoconazole]], lead to an inhibition of halofantrine metabolism. Further, in dogs orally administered ketoconazole, the metabolism of halofantrine was decreased (SEE WARNINGS).<ref>{{Cite web | last = | first = | title = http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/20250s7s8lbl.pdf | url =http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/20250s7s8lbl.pdf | publisher = | date = | accessdate = }}</ref> | |||
<ref>{{Cite web | last = | first = | title = http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/20250s7s8lbl.pdf | url =http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/20250s7s8lbl.pdf | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 02:59, 7 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Drug Interactions
Although no drug interaction studies have been conducted, Halfan should not be administered with drugs known to prolong the QTc interval. In clinical use, an interaction with mefloquine has been reported to lead to further prolongation of the QTc interval.1 The prolongation may be significant and potentially fatal; therefore, Halfan should not be given simultaneously with or subsequent to mefloquine. There have been no drug interactions reported when halofantrine is coadministered with chloroquine.
In vitro studies have shown that drugs which inhibit cytochrome CYP3A4, e.g., ketoconazole, lead to an inhibition of halofantrine metabolism. Further, in dogs orally administered ketoconazole, the metabolism of halofantrine was decreased (SEE WARNINGS).[1]
References
- ↑ "http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/20250s7s8lbl.pdf" (PDF). External link in
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Adapted from the FDA Package Insert.