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| __NOTOC__
| | {{Details0|Bacitracin (Injection)}} |
| {{Bacitracin}} | | {{Details0|Bacitracin (topical)}} |
| {{CMG}}; {{AE}} {{MM}} | | {{Details0|Bacitracin (opthalmic)}} |
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| ==Overview==
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| '''Bacitracin''' is a mixture of related cyclic [[peptide|polypeptide]]s produced by [[organism]]s of the licheniformis group of ''[[Bacillus subtilis]]'' ''var'' Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy.<ref>Johnson B, Anker H, Meleney F (1945). "Bacitracin: a new antibiotic produced by a member of the B. subtilis group". ''[[Science (journal)|Science]]'' '''102''' (2650): 376–377.</ref> As a toxic and difficult-to-use [[antibiotic]], bacitracin doesn't work well orally. However, it is very effective topically.
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| Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that [[ribosome]]s are not involved in its [[nonribosomal peptide|synthesis]].
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| ==Category==
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| ==US Brand Names==
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| BACIIM<sup>®</sup>
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| ==FDA Package Insert==
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| '''[[Bacitracin description|Description]]'''
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| '''| [[Bacitracin clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Bacitracin indications and usage|Indications and Usage]]'''
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| '''| [[Bacitracin contraindications|Contraindications]]'''
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| '''| [[Bacitracin warnings and precautions|Warnings and Precautions]]'''
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| '''| [[Bacitracin adverse reactions|Adverse Reactions]]'''
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| '''| [[Bacitracin dosage and administration|Dosage and Administration]]'''
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| '''| [[Bacitracin how supplied|How Supplied]]'''
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| ==Mechanism of Action==
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| Bacitracin interferes with the dephosphorylation of the [[carbon|C]]<sub>55</sub>-isoprenyl pyrophosphate, a molecule which carries the building blocks of the [[peptidoglycan]] bacterial [[cell wall]] outside of the inner membrane [http://www.pnas.org/cgi/content/abstract/68/12/3223].
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antibiotics]]
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| [[Category:Wikinfect]]
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