|
|
| Line 3: |
Line 3: |
| {{CMG}}; {{AE}} {{chetan}} | | {{CMG}}; {{AE}} {{chetan}} |
|
| |
|
| ==Precautions==
| | <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = CHLOROQUINE (CHLOROQUINE PHOSPHATE) TABLET CHLOROQUINE (CHLOROQUINE PHOSPHATE) TABLET, COATED [WEST-WARD PHARMACEUTICAL CORP] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9b585ad5-ae86-4403-b83f-8d8363d43da5 | publisher = | date = | accessdate = }}</ref> |
| | |
| ===Hematological Effects/Laboratory Tests===
| |
| | |
| Complete blood cell counts should be made periodically if patients are given prolonged therapy. If any severe blood disorder appears which is not attributable to the disease under treatment, discontinuance of the drug should be considered.
| |
| | |
| The drug should be administered with caution to patients having G-6-PD ([[glucose-6 phosphate dehydrogenase]]) deficiency.
| |
| | |
| ===Auditory Effects===
| |
| | |
| In patients with preexisting auditory damage, chloroquine should be administered with caution. In case of any defects in hearing, chloroquine should be immediately discontinued, and the patients closely observed (see Adverse Reactions).
| |
| | |
| ===Hepatic Effects===
| |
| | |
| Since this drug is known to concentrate in the liver, it should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.
| |
| | |
| ===Central Nervous System Effects===
| |
| | |
| Patients with a history of [[epilepsy]] should be advised about the risk of chloroquine provoking seizures.
| |
| | |
| ===Drug Interactions===
| |
| | |
| ====Antacids and kaolin====
| |
| [[Antacids]] and [[kaolin]] can reduce the absorption of chloroquine; an interval of at least 4 hours between intake of these agents and chloroquine should be observed.
| |
| | |
| ====Cimetidine====
| |
| [[Cimetidine]] can inhibit the metabolism of chloroquine, increasing its plasma level. Concomitant use of cimetidine should be avoided.
| |
| | |
| ====Ampicillin====
| |
| In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of [[ampicillin]]. An interval of at least two hours between intake of this agent and chloroquine should be observed.
| |
| | |
| ====Cyclosporine====
| |
| After introduction of chloroquine (oral form), a sudden increase in serum [[cyclosporine]] level has been reported. Therefore, close monitoring of serum cyclosporine level is recommended and, if necessary, chloroquine should be discontinued.
| |
| | |
| ====Mefloquine====
| |
| Co-administration of chloroquine and [[mefloquine]] may increase the risk of convulsions.
| |
| | |
| The blood concentrations of chloroquine and desethylchloroquine (the major metabolite of chloroquine, which also has antimalarial properties) were negatively associated with log antibody titers. Chloroquine taken in the dose recommended for malaria prophylaxis can reduce the antibody response to primary immunization with intradermal human diploid-cell rabies vaccine.
| |
| | |
| ===Pregnancy===
| |
| | |
| See Warnings, Usage in Pregnancy.
| |
| | |
| ===Nursing Mothers===
| |
| | |
| Because of the potential for serious adverse reactions in nursing infants from chloroquine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the potential clinical benefit of the drug to the mother.
| |
| | |
| The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in eleven lactating mothers following a single dose of chloroquine (600 mg base). The maximum daily dose of the drug that the infant can receive from breastfeeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy. Separate chemoprophylaxis for the infant is required. See Dosage And Administration.
| |
| | |
| ===Pediatric Use===
| |
| | |
| See Warnings and Dosage And Administration.
| |
| | |
| ===Geriatric Use===
| |
| | |
| Clinical studies of Chloroquine Phosphate Tablets did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, this drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = CHLOROQUINE (CHLOROQUINE PHOSPHATE) TABLET CHLOROQUINE (CHLOROQUINE PHOSPHATE) TABLET, COATED [WEST-WARD PHARMACEUTICAL CORP] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9b585ad5-ae86-4403-b83f-8d8363d43da5 | publisher = | date = | accessdate = }}</ref>
| |
|
| |
|
| ==References== | | ==References== |