Josamycin: Difference between revisions

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m Changed protection level for "Josamycin" ([Edit=Allow only autoconfirmed users] (expires 19:49, 22 January 2014 (UTC)) [Move=Allow only autoconfirmed users] (expires 19:49, 22 January 2014 (UTC)))
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m Protected "Josamycin": Bot: Protecting all pages from category Drug ([Edit=Allow only administrators] (indefinite) [Move=Allow only administrators] (indefinite))
 
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{{drugbox
{{Drugbox
| IUPAC_name        =  
| Verifiedfields = changed
| image            = Josamycin.png
| verifiedrevid = 477496532
| CAS_number        = 16846-24-5
| IUPAC_name = (2''S'',3''S'',4''R'',6''S'') -6- {[(2''R'',3''S'',4''R'',5''R'',6''S'') -6- {[(4''R'',5''S'',6''S'',7''R'',9''R'',10''R'',11''E'',13''E'',16''R'') -4- (acetyloxy)-10-hydroxy-5-methoxy-9, 16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11, 13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2, 4-dimethyloxan-3-yl 3-methylbutanoate
| ATC_prefix        = J01
| image =Josamycin.png
| ATC_suffix        = FA07
| image2 =Josamycin ball-and-stick.png
| PubChem          = 5282165
<!--Clinical data-->
| DrugBank          =  
| tradename =
| C=42|H=69|N=1|O=15
| Drugs.com = {{drugs.com|international|josamycin}}
| molecular_weight  = 827.995 g/mol
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| bioavailability  =
| pregnancy_US = <!-- A / B            / C / D / X -->
| protein_bound    =
| pregnancy_category =   
| metabolism        =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| elimination_half-life =
| legal_CA = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| excretion        =
| legal_UK = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| pregnancy_AU     = <!-- A / B1 / B2 / B3 / C / D / X -->
| legal_US = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| pregnancy_US     = <!-- A / B            / C / D / X -->
| legal_status =
| pregnancy_category=   
| routes_of_administration =
| legal_AU         = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
 
| legal_CA         = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
<!--Pharmacokinetic data-->
| legal_UK         = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| bioavailability = 
| legal_US         = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| protein_bound = 
| legal_status     =  
| metabolism = 
| routes_of_administration =  
| elimination_half-life = 
| excretion =
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 16846-24-5
| ATC_prefix = J01
| ATC_suffix = FA07
| PubChem = 5284579
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01321
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4447629
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = HV13HFS217
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01235
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 31739
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 224436
| PDB_ligand = JOS
 
<!--Chemical data-->
| C=42 | H=69 | N=1 | O=15
| molecular_weight = 827.995 g/mol
| smiles = O=CC[C@H]3C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@H](OC(=O)C[C@@H](OC(=O)C)C(OC)[C@H]3O[C@@H]2O[C@@H]([C@@H](O[C@@H]1O[C@H]([C@@H](OC(=O)CC(C)C)[C@](O)(C1)C)C)[C@H](N(C)C)[C@H]2O)C)C
| InChI = 1/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39?,40-,41+,42-/m1/s1
| InChIKey = XJSFLOJWULLJQS-HTYUZQQABV
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39?,40-,41+,42-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = XJSFLOJWULLJQS-HTYUZQQASA-N
}}
}}
__Notoc__
{{SI}}
{{SI}}
{{CMG}}
==Overview==
'''Josamycin''' is a [[macrolide]] antibiotic. It is synthesized from strains of ''Streptomyces narbonensis'' var. ''josamyceticus'' var. ''nova''
Currently sold in various countries.


Brand examples are:


'''Josamycin''' is a [[macrolide]] antibiotic.
Europe: '''Josalid''',  '''Josacine''', '''Iosalide''', '''Josamina'''.
Russia: '''Wilprafen''' ('''Вильпрафен''').
Japan: '''Josamy'''.


==Adverse effects==


There has been a case report of [[oedema]] of the feet.<ref>{{ cite pmid | 8343666 }}</ref>


{{Macrolides, lincosamides and streptogramins}}
==References==
{{Reflist|2}}


[[Category:Macrolide antibiotics]]


{{Macrolides, lincosamides and streptogramins}}


[[ru:Джозамицин]]


{{WH}}
[[Category:Macrolide antibiotics]]
{{WikiDoc Sources}}
[[Category:Drug]]

Latest revision as of 16:33, 20 August 2015

Josamycin
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC42H69NO15
Molar mass827.995 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Josamycin is a macrolide antibiotic. It is synthesized from strains of Streptomyces narbonensis var. josamyceticus var. nova

Currently sold in various countries.

Brand examples are:

Europe: Josalid, Josacine, Iosalide, Josamina. Russia: Wilprafen (Вильпрафен). Japan: Josamy.

Adverse effects

There has been a case report of oedema of the feet.[1]

References

  1. ↑ PMID 8343666 (PMID 8343666)
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