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| __NOTOC__
| | #REDIRECT [[Pentamidine]] |
| {{Pentamidine Isethionate}}
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| '''''For patient information, click <u>[[Pentamidine Isethionate (patient information)|here]]'''''</u>.
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| {{CMG}}; {{AE}} {{MM}}
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| ==Overview==
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| '''Pentamidine''' (formulated as a salt, pentamidine di[[isethionate]] or di[[mesilate]]) is an [[antimicrobial]] [[medication]] given for prevention and treatment of [[Pneumocystis pneumonia]] (PCP) caused by ''Pneumocystis jirovecii'' (formerly known as ''Pneumocystis carinii''), a severe interstitial type of [[pneumonia]] often seen in patients with [[HIV]] infection. The drug is also the mainstay of treatment for stage I infection with ''[[Trypanosoma brucei]] gambiense'' (West African [[Trypanosomiasis]]).
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| ==Category==
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| [[Antiprotozoal]]
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| ==US Brand Names==
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| PENTAM 300<sup>®</sup>
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| ==FDA Package Insert==
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| ''' [[Pentamidine Isethionate description|Description]]'''
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| '''| [[Pentamidine Isethionate clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Pentamidine Isethionate indications and usage|Indications and Usage]]'''
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| '''| [[Pentamidine Isethionate contraindications|Contraindications]]'''
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| '''| [[Pentamidine Isethionate warnings and precautions|Warnings and Precautions]]'''
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| '''| [[Pentamidine Isethionate adverse reactions|Adverse Reactions]]'''
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| '''| [[Pentamidine Isethionate overdosage|Overdosage]]'''
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| '''| [[Pentamidine Isethionate dosage and administration|Dosage and Administration]]'''
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| '''| [[Pentamidine Isethionate how supplied|How Supplied]]'''
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| '''| [[Pentamidine Isethionate labels and packages|Labels and Packages]]'''
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| ==Mechanism of Action==
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| Pentamidine isethionate, an aromatic diamidine, is known to have activity against Pneumocystis carinii. The mode of action of pentamidine is not fully understood. In vitro studies indicate that the drug interferes with protozoal nuclear metabolism by inhibition of DNA, RNA, phospholipid and protein synthesis.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = PENTAM 300 (PENTAMIDINE ISETHIONATE) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [APP PHARMACEUTICALS, LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=cc2b635e-4840-4dc3-a177-5484371680e8 | publisher = | date = | accessdate}}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antibiotics]]
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| [[Category:Wikinfect]]
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