Pyrimethamine adverse reactions: Difference between revisions
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Hypersensitivity reactions, occasionally severe (such as Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, and anaphylaxis), and [[hyperphenylalaninemia]], can occur particularly when pyrimethamine is administered concomitantly with a sulfonamide. Consult the complete prescribing information for the relevant sulfonamide for sulfonamide-associated adverse events. With doses of pyrimethamine used for the treatment of toxoplasmosis, anorexia and vomiting may occur. Vomiting may be minimized by giving the medication with meals; it usually disappears promptly upon reduction of dosage. Doses used in toxoplasmosis may produce megaloblastic anemia, leukopenia, thrombocytopenia, pancytopenia, [[atrophic glossitis]], [[hematuria]], and disorders of cardiac rhythm. Hematologic effects, however, may also occur at low doses in certain individuals (see | Hypersensitivity reactions, occasionally severe (such as [[Stevens-Johnson syndrome]], [[toxic epidermal necrolysis]], [[erythema multiforme]], and [[anaphylaxis]]), and [[hyperphenylalaninemia]], can occur particularly when pyrimethamine is administered concomitantly with a sulfonamide. Consult the complete prescribing information for the relevant sulfonamide for sulfonamide-associated adverse events. With doses of pyrimethamine used for the treatment of [[toxoplasmosis]], anorexia and vomiting may occur. Vomiting may be minimized by giving the medication with meals; it usually disappears promptly upon reduction of dosage. Doses used in toxoplasmosis may produce [[megaloblastic anemia]], [[leukopenia]], [[thrombocytopenia]], [[pancytopenia]], [[atrophic glossitis]], [[hematuria]], and disorders of cardiac rhythm. Hematologic effects, however, may also occur at low doses in certain individuals (see Precautions; General). | ||
[[Pulmonary eosinophilia]] has been reported rarely.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DARAPRIM (PYRIMETHAMINE) TABLET [AMEDRA PHARMACEUTICALS LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3e4d5027-7939-480f-ae19-82e764d9fa97#nlm34089-3 | publisher = | date = | accessdate = }}</ref> | [[Pulmonary eosinophilia]] has been reported rarely.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DARAPRIM (PYRIMETHAMINE) TABLET [AMEDRA PHARMACEUTICALS LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3e4d5027-7939-480f-ae19-82e764d9fa97#nlm34089-3 | publisher = | date = | accessdate = }}</ref> | ||
Latest revision as of 22:28, 9 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Adverse Reactions
Hypersensitivity reactions, occasionally severe (such as Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, and anaphylaxis), and hyperphenylalaninemia, can occur particularly when pyrimethamine is administered concomitantly with a sulfonamide. Consult the complete prescribing information for the relevant sulfonamide for sulfonamide-associated adverse events. With doses of pyrimethamine used for the treatment of toxoplasmosis, anorexia and vomiting may occur. Vomiting may be minimized by giving the medication with meals; it usually disappears promptly upon reduction of dosage. Doses used in toxoplasmosis may produce megaloblastic anemia, leukopenia, thrombocytopenia, pancytopenia, atrophic glossitis, hematuria, and disorders of cardiac rhythm. Hematologic effects, however, may also occur at low doses in certain individuals (see Precautions; General).
Pulmonary eosinophilia has been reported rarely.[1]
References
Adapted from the FDA Package Insert.