Amphotericin B lipid complex: Difference between revisions
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==Overview== | ==Overview== | ||
'''Amphotericin B''' is a [[polyene antimycotic|polyene]] [[Antifungal medication|antifungal drug]], often used [[intravenous]]ly for systemic[[fungi|fungal]] [[infection]]s. It was originally extracted from ''[[Streptomyces]] [[Streptomyces]] nodosus'', a [[hypha|filamentous]][[bacterium]], in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical's [[amphoteric]] properties. Two amphotericins, amphotericin A and amphotericin B are known, but only B is used clinically, because it is significantly more active [[in vivo]]. Amphotericin A is almost identical to amphotericin B (having a double C=C bond between the 27th and 28th carbons), but has little antifungal activity. | |||
Currently, the drug is available as '''plain amphotericin B''', as a '''cholesteryl sulfate complex (ABCD)''', as a '''lipid complex (ABLC)''', and as a '''[[liposome|liposomal]] formulation''' (LAmB). The latter formulations have been developed to improve tolerability for the patient, but may show considerably different pharmacokinetic characteristics compared to plain amphotericin B. | |||
==Category== | ==Category== | ||
Antifungal drug | |||
==US Brand Names== | ==US Brand Names== | ||
ABELCET<sup>®</sup> | '''ABELCET<sup>®</sup>''' | ||
==FDA Package Insert== | ==FDA Package Insert== | ||
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'''| [[Amphotericin B lipid complex drug interactions|Drug Interactions]]''' | '''| [[Amphotericin B lipid complex drug interactions|Drug Interactions]]''' | ||
'''| [[Amphotericin B lipid complex overdosage|Overdosage]]''' | '''| [[Amphotericin B lipid complex overdosage|Overdosage]]''' | ||
'''| [[Amphotericin B lipid complex dosage and administration|Dosage and Administration]]''' | '''| [[Amphotericin B lipid complex dosage and administration|Dosage and Administration]]''' | ||
'''| [[Amphotericin B lipid complex how supplied|How Supplied]]''' | '''| [[Amphotericin B lipid complex how supplied|How Supplied]]''' | ||
Latest revision as of 05:11, 10 January 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Overview
Amphotericin B is a polyene antifungal drug, often used intravenously for systemicfungal infections. It was originally extracted from Streptomyces Streptomyces nodosus, a filamentousbacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical's amphoteric properties. Two amphotericins, amphotericin A and amphotericin B are known, but only B is used clinically, because it is significantly more active in vivo. Amphotericin A is almost identical to amphotericin B (having a double C=C bond between the 27th and 28th carbons), but has little antifungal activity.
Currently, the drug is available as plain amphotericin B, as a cholesteryl sulfate complex (ABCD), as a lipid complex (ABLC), and as a liposomal formulation (LAmB). The latter formulations have been developed to improve tolerability for the patient, but may show considerably different pharmacokinetic characteristics compared to plain amphotericin B.
Category
Antifungal drug
US Brand Names
ABELCET®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Dosage and Administration | How Supplied | Labels and Packages