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| ==Definition==
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| Sepsis is a systemic, deleterious host response to infection, manifested as multi system organ dysfunction plus hypotension, that is not readily reversible with fluid resuscitation.
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| ===Diagnostic Criteria For Sepsis (Documented/Suspected Infection '''Plus''' Inflammatory variables'''Plus''' One of The Organ Dysfunction)===
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| ----
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| :'''General variables'''
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| :*Fever > 38.3°C
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| :*Hypothermia ( core temperature < 36°C )
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| :*Heart rate > 90/min–1 or > 2 SD above the normal value for age
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| :*Tachypnea
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| :*Altered mental status
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| :*Edema
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| :*Positive fluid balance ( > 20 mL/kg over 24 hr)
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| :*Hyperglycemia ( plasma glucose > 140 mg/dL or 7.7 mmol/L ) in the absence of diabetes
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| :'''Inflammatory variables'''
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| :*Leukocytosis ( WBC count > 12,000 µL–1 )
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| :*Leukopenia ( WBC count < 4000 µL–1 )
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| :*Immature WBCs forms are > 10% with normal count
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| :*Plasma C-reactive protein > 2 SD above the normal value
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| :*Plasma procalcitonin > 2 SD above the normal value
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| :'''Hemodynamic variables'''
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| :*Arterial hypotension after 30 ml/kg fluid bolus ( SBP < 90 mm Hg, MAP < 70 mm Hg, or an SBP decrease > 40 mm Hg in adults or < 2 SD below normal for age )
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| :'''Organ dysfunction variables'''
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| :*Arterial hypoxemia ( Pao2/Fio2 < 300 )
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| :*Acute oliguria ( urine output < 0.5 mL/kg/hr for at least 2 hrs despite adequate fluid resuscitation )
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| :*Creatinine increase > 0.5 mg/dL or 44.2 µmol/L
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| :*Coagulation abnormalities ( INR > 1.5 or aPTT > 60 Sec )
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| :*Ileus ( absent bowel sounds )
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| :*Thrombocytopenia ( platelet count < 100,000 µL–1 )
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| :*Hyperbilirubinemia ( plasma total bilirubin > 4 mg/dL or 70 µmol/L )
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| :'''Tissue perfusion variables'''
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| :*Hyperlactatemia > 1 mmol/L
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| :*Decreased capillary refill or mottling
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