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| __NOTOC__
| | #REDIRECT [[Atorvastatin#Structure]] |
| {{Atorvastatin}}
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| {{CMG}} ; {{AE}} , {{PB}}
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| LIPITOR is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of [[3-hydroxy-3-methylglutaryl-coenzyme A]] ([[HMG-CoA) reductase]]. This enzyme catalyzes the conversion of [[HMG-CoA to mevalonate]], an early and rate-limiting step in cholesterol biosynthesis.
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| Atorvastatin calcium is [R-(R*, R*)]-2-(4-fluorophenyl)-ß, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, calcium salt (2:1) trihydrate. The empirical formula of atorvastatin calcium is (C33H34 FN2O5)2Ca•3H2O and its molecular weight is 1209.42. Its structural formula is: | |
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| Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile; slightly soluble in ethanol; and freely soluble in methanol.
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| LIPITOR Tablets for oral administration contain 10, 20, 40, or 80 mg atorvastatin and the following inactive ingredients: calcium carbonate, USP; candelilla wax, FCC; croscarmellose sodium, NF; hydroxypropyl cellulose, NF; lactose monohydrate, NF; magnesium stearate, NF; microcrystalline cellulose, NF; Opadry White YS-1-7040 (hypromellose, polyethylene glycol, talc, titanium dioxide); polysorbate 80, NF; simethicone emulsion.
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