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| __NOTOC__
| | #REDIRECT [[Isosorbide mononitrate#Drug Interactions]] |
| {{Isosorbide mononitrate}}
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| {{CMG}}; {{AE}} {{PB}}
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| Isosorbide mononitrate extended-release tablets are indicated for the prevention of [[angina pectoris]] due to [[coronary artery disease]]. The onset of action of oral ISMN is not sufficiently rapid for this product to be useful in aborting an acute angina episode.
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| The concomitant administration of agents with hypotensive effects and psychotherapeutic agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics), narcotic analgesics, alcohol, or muscle relaxants may additively increase hypotensive and/or central nervous system depressant effects
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| ==Major Interactions==
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| {{refbegin|3}}
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| * [[Cialis]]
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| * [[Levitra]]
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| * [[Revatio]]
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| * [[sildenafil]]
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| * [[tadalafil]]
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| * [[tizanidine]]
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| * [[vardenafil]]
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| * [[Viagra]]
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| * [[Zanaflex]]
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| {{refend}}
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| ==Moderate Interactions==
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| {{refbegin|3}}
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| * [[40 Winks]]
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| * [[Abilify]]
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| * [[Abilify Discmelt]]
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| * [[Accupril]]
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| * [[Aceon]]
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| * [[Actiq]]
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| * [[Activase]]
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| * [[Adapin]]
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| * [[Adgan]]
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| * [[Aler-Dryl]]
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| * [[Aler-Tab]]
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| * [[Alfenta]]
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| * [[alfentanil]]
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| * [[All Day Allergy]]
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| * [[Allergia-C]]
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| * [[Allermax]]
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| * [[alprazolam]]
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| * [[alprazolam extended release]]
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| * [[Altace]]
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| * [[Altaryl]]
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| * [[alteplase]]
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| * [[Ambien]]
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| * [[Ambien CR]]
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| * [[amitriptyline]]
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| * [[amoxapine]]
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| * [[Anafranil]]
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| * [[Anergan 50]]
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| * [[Antiflex]]
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| * [[Antinaus 50]]
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| * [[APO-Go]]
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| * [[APO-Go Pen]]
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| * [[Apokyn]]
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| * [[apomorphine]]
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| * [[Aquachloral Supprettes]]
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| * [[aripiprazole]]
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| * [[Asendin]]
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| * [[Astramorph PF]]
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| * [[Atarax]]
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| * [[Ativan]]
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| * [[Aventyl HCl]]
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| * [[Avinza]]
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| * [[baclofen]]
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| * [[Banaril]]
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| * [[Banflex]]
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| * [[Banophen]]
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| * [[Beldin]]
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| * [[Belix]]
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| * [[Ben-Tann]]
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| * [[Benadryl]]
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| * [[Benadryl Allergy]]
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| * [[Benadryl Child Dye Free]]
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| * [[Benadryl Childrens Allergy Fastmelt]]
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| * [[Benadryl DF]]
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| * [[Benadryl Dye Free Allergy]]
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| * [[Benadryl Ultratab]]
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| * [[Benahist-10]]
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| * [[Benahist-50]]
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| * [[Benoject-50]]
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| * [[bromocriptine]]
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| * [[Budeprion SR]]
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| * [[Budeprion XL]]
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| * [[Buprenex]]
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| * [[Buprenorphine]]
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| * [[bupropion]]
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| * [[bupropion 24 hour extended release]]
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| * [[bupropion extended release]]
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| * [[Busodium]]
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| * [[BuSpar]]
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| * [[BuSpar Dividose]]
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| * [[buspirone]]
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| * [[butabarbital]]
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| * [[Butisol Sodium]]
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| * [[Bydramine]]
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| * [[cabergoline]]
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| * [[Calm-Aid]]
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| * [[Capoten]]
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| * [[captopril]]
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| * [[Carbacot]]
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| * [[Cathflo Activase]]
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| * [[Celexa]]
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| * [[cetirizine]]
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| * [[chloral hydrate]]
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| * [[chlordiazepoxide]]
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| * [[chlorpromazine]]
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| * [[chlorpromazine extended release]]
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| * [[citalopram]]
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| * [[clomipramine]]
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| * [[clonazepam]]
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| * [[Clopine]]
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| * [[clorazepate]]
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| * [[clorazepate extended release]]
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| * [[clozapine]]
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| * [[Clozapine Synthon]]
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| * [[Clozaril]]
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| * [[codeine]]
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| * [[codeine phosphate]]
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| * [[codeine sulfate]]
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| * [[Compazine]]
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| * [[Compazine Spansule]]
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| * [[Compoz Nighttime Sleep Aid]]
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| * [[Compro]]
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| * [[D.H.E. 45]]
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| * [[Dalmane]]
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| * [[Darvon]]
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| * [[Darvon-N]]
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| * [[Dazidox]]
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| * [[Demerol HCl]]
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| * [[Denzapine]]
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| * [[Desyrel]]
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| * [[Desyrel Dividose]]
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| * [[Diastat]]
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| * [[Diastat AcuDial]]
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| * [[Diastat Pediatric]]
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| * [[diazepam]]
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| * [[dihydrocodeine]]
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| * [[dihydroergotamine]]
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| * [[Dilaudid]]
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| * [[Dilaudid-5]]
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| * [[Dilaudid-HP]]
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| * [[Diphedryl]]
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| * [[Diphen]]
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| * [[Diphen AF]]
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| * [[Diphen Cough]]
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| * [[Diphenadryl]]
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| * [[Diphendryl]]
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| * [[Diphenhist]]
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| * [[diphenhydramine]]
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| * [[diphenhydramine citrate]]
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| * [[diphenhydramine tannate]]
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| * [[Diphenmax]]
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| * [[Diphenydramine Quick Melt]]
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| * [[Diphenyl]]
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| * [[Diphenylin]]
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| * [[Diskets]]
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| * [[Dizac]]
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| * [[Dolophine]]
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| * [[Doloral]]
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| * [[Doloral Sirop]]
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| * [[Doral]]
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| * [[Dostinex]]
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| * [[doxepin]]
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| * [[doxepin topical]]
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| * [[DPH]]
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| * [[Duragesic]]
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| * [[Duragesic-100]]
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| * [[Duragesic-12]]
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| * [[Duragesic-25]]
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| * [[Duragesic-50]]
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| * [[Duragesic-75]]
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| * [[Duramorph PF]]
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| * [[Dytan]]
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| * [[Dytuss]]
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| * [[Effexor]]
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| * [[Effexor XR]]
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| * [[Elavil]]
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| * [[enalapril]]
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| * [[enalaprilat]]
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| * [[Endep]]
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| * [[Endocodone]]
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| * [[Equanil]]
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| * [[Ergomar]]
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| * [[ergonovine]]
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| * [[ergotamine]]
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| * [[Ergotrate Maleate]]
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| * [[escitalopram]]
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| * [[ETH-Oxydose]]
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| * [[FazaClo]]
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| * [[fentanyl]]
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| * [[Fentora]]
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| * [[Flexoject]]
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| * [[Flexon]]
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| * [[fluoxetine]]
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| * [[fluoxetine extended release]]
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| * [[fluphenazine]]
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| * [[fluphenazine decanoate]]
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| * [[fluphenazine enanthate]]
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| * [[fluphenazine hydrochloride]]
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| * [[flurazepam]]
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| * [[fluvoxamine]]
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| * [[fluvoxamine extended release]]
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| * [[fosinopril]]
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| * [[Genahist]]
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| * [[Geodon]]
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| * [[Haldol]]
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| * [[Haldol Decanoate]]
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| * [[haloperidol]]
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| * [[haloperidol decanoate]]
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| * [[Hydramine]]
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| * [[Hydramine Compound]]
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| * [[Hydramine Cough Syrup]]
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| * [[Hydromorph Contin]]
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| * [[hydromorphone]]
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| * [[hydromorphone extended release]]
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| * [[Hydrostat IR]]
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| * [[hydroxyzine]]
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| * [[hydroxyzine hydrochloride]]
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| * [[hydroxyzine pamoate]]
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| * [[Hyrexin]]
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| * [[Hyzine]]
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| * [[iloprost]]
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| * [[imipramine]]
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| * [[imipramine pamoate]]
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| * [[Infumorph]]
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| * [[Invega]]
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| * [[Ionsys]]
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| * [[Kadian]]
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| * [[Klonopin]]
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| * [[Klonopin Wafer]]
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| * [[levocetirizine]]
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| * [[Levrix]]
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| * [[Lexapro]]
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| * [[Librium]]
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| * [[Lioresal]]
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| * [[Lioresal Intrathecal]]
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| * [[lisinopril]]
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| * [[lorazepam]]
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| * [[loxapine]]
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| * [[Loxitane]]
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| * [[Loxitane C]]
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| * [[Loxitane IM]]
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| * [[Ludiomil]]
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| * [[Luminal]]
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| * [[Luvox]]
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| * [[Luvox CR]]
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| * [[M-Eslon]]
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| * [[M-Oxy]]
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| * [[M. O. S.]]
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| * [[maprotiline]]
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| * [[maraviroc]]
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| * [[Mavik]]
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| * [[MB-TAB]]
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| * [[Mellaril]]
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| * [[Mellaril-S]]
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| * [[meperidine]]
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| * [[meprobamate]]
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| * [[methadone]]
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| * [[Methadose]]
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| * [[methdilazine]]
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| * [[Methergine]]
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| * [[methocarbamol]]
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| * [[methylergonovine]]
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| * [[methysergide maleate]]
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| * [[midazolam]]
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| * [[Migranal]]
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| * [[Miltown]]
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| * [[minoxidil topical]]
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| * [[Mio-Rel]]
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| * [[mirtazapine]]
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| * [[Mitran]]
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| * [[moexipril]]
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| * [[Monopril]]
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| * [[morphine]]
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| * [[morphine 24 hour extended release]]
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| * [[morphine extended release]]
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| * [[Morphine IR]]
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| * [[Morphine LP Epidural]]
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| * [[morphine preservative-free]]
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| * [[Morphine Rapi-Ject]]
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| * [[Morphitec]]
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| * [[MS]]
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| * [[MS Contin]]
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| * [[MS/S]]
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| * [[MSIR]]
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| * [[Myolin]]
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| * [[nalbuphine]]
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| * [[Natrecor]]
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| * [[nefazodone]]
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| * [[Nervine]]
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| * [[nesiritide]]
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| * [[Nightime Sleepaid]]
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| * [[Niravam]]
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| * [[Norflex]]
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| * [[Norflex Injectable]]
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| * [[nortriptyline]]
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| * [[Nu-Med]]
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| * [[Nubain]]
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| * [[Nytol Caplet]]
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| * [[olanzapine]]
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| * [[OMS]]
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| * [[opium]]
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| * [[Opium Deodorized]]
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| * [[Oramorph SR]]
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| * [[Orfro]]
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| * [[Ormazine]]
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| * [[orphenadrine]]
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| * [[orphenadrine extended release]]
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| * [[Orphenate]]
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| * [[oxazepam]]
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| * [[oxycodone]]
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| * [[oxycodone extended release]]
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| * [[OxyContin]]
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| * [[Oxyfast]]
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| * [[OxyIR]]
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| * [[paliperidone]]
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| * [[Palladone]]
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| * [[Palladone SR]]
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| * [[Pamelor]]
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| * [[Paral]]
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| * [[paraldehyde]]
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| * [[Pardryl]]
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| * [[Paregoric]]
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| * [[Parlodel]]
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| * [[paroxetine]]
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| * [[paroxetine extended release]]
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| * [[paroxetine mesylate]]
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| * [[Paxil]]
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| * [[Paxil CR]]
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| * [[Pentazine]]
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| * [[pentazocine]]
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| * [[Percolone]]
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| * [[perindopril]]
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| * [[Permitil]]
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| * [[perphenazine]]
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| * [[Pexeva]]
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| * [[Phenadoz]]
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| * [[Phenazine 50]]
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| * [[Phenergan]]
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| * [[Phenergan Fortis]]
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| * [[phenobarbital]]
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| * [[Phenoject-50]]
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| * [[PP-Cap]]
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| * [[Prinivil]]
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| * [[Pro-Med]]
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| * [[prochlorperazine]]
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| * [[prochlorperazine extended release]]
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| * [[Procot]]
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| * [[Prolixin]]
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| * [[Prolixin Decanoate]]
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| * [[Prolixin Enanthate]]
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| * [[Promacot]]
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| * [[promazine]]
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| * [[promethazine]]
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| * [[Promethegan]]
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| * [[propoxyphene]]
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| * [[propoxyphene hydrochloride]]
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| * [[propoxyphene napsylate]]
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| * [[Prorex]]
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| * [[Prozac]]
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| * [[Prozac Weekly]]
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| * [[Prudoxin]]
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| * [[Q-Dryl]]
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| * [[Q-Dryl A/F]]
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| * [[quazepam]]
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| * [[Quenalin]]
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| * [[quetiapine]]
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| * [[quetiapine extended release]]
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| * [[quinapril]]
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| * [[ramipril]]
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| * [[Rapiflux]]
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| * [[Remeron]]
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| * [[Remeron SolTab]]
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| * [[Rescudose]]
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| * [[Restoril]]
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| * [[Rezine]]
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| * [[Risperdal]]
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| * [[Risperdal Consta]]
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| * [[Risperdal M-Tab]]
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| * [[risperidone]]
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| * [[RMS]]
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| * [[Robaxin]]
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| * [[Robaxin-750]]
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| * [[Rogaine]]
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| * [[Rogaine Extra Strength]]
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| * [[Ronoxidil]]
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| * [[Roxanol]]
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| * [[Roxanol 100]]
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| * [[Roxanol-T]]
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| * [[Roxicodone]]
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| * [[Roxicodone Intensol]]
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| * [[Sansert]]
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| * [[Sarafem]]
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| * [[Scot-Tussin Allergy Relief Formula]]
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| * [[secobarbital]]
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| * [[Seconal Sodium]]
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| * [[Selzentry]]
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| * [[Serax]]
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| * [[Seroquel]]
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| * [[Seroquel XR]]
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| * [[sertraline]]
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| * [[Serzone]]
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| * [[Siladryl]]
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| * [[Siladryl DAS]]
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| * [[Siladyl SA]]
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| * [[Silphen Cough]]
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| * [[Simply Sleep]]
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| * [[Sinequan]]
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| * [[Skelex]]
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| * [[Sleep Tab II]]
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| * [[Sleep Tabs]]
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| * [[Sleep-ettes]]
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| * [[Sleep-Eze-3]]
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| * [[Sleepinal]]
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| * [[Solfoton]]
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| * [[Sominex]]
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| * [[Sominex Maximum Strength Caplet]]
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| * [[Somnicaps]]
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| * [[Somnote]]
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| * [[Sonata]]
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| * [[Sparine]]
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| * [[Statex]]
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| * [[Stelazine]]
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| * [[Sublimaze]]
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| * [[Subutex]]
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| * [[Surmontil]]
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| * [[Tacaryl]]
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| * [[Talwin Lactate]]
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| * [[temazepam]]
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| * [[Theraflu Thin Strips Multi Symptom]]
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| * [[thioridazine]]
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| * [[Thorazine]]
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| * [[tissue plasminogen activator]]
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| * [[Tofranil]]
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| * [[Tofranil-PM]]
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| * [[Total Allergy]]
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| * [[TPA]]
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| * [[trandolapril]]
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| * [[Tranxene SD]]
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| * [[Tranxene T-Tab]]
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| * [[trazodone]]
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| * [[Triaminic Thin Strips Cough & Runny Nose]]
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| * [[trifluoperazine]]
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| * [[Trilafon]]
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| * [[trimipramine]]
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| * [[Trux-adryl]]
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| * [[Tusstat]]
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| * [[Twilite]]
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| * [[Uni-Tann]]
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| * [[Unisom Sleepgels Maximum Strength]]
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| * [[Univasc]]
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| * [[Uprima]]
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| * [[V-Gan-25]]
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| * [[V-Gan-50]]
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| * [[Valium]]
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| * [[Valrelease]]
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| * [[Valu-Dryl]]
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| * [[Vanatrip]]
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| * [[Vasotec]]
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| * [[venlafaxine]]
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| * [[venlafaxine extended release]]
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| * [[Ventavis]]
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| * [[Versed]]
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| * [[verteporfin]]
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| * [[Vistacon]]
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| * [[Vistacot]]
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| * [[Vistaject-50]]
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| * [[Vistaril]]
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| * [[Vistaril IM]]
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| * [[Vistazine]]
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| * [[Vistazine 50]]
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| * [[Visudyne]]
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| * [[Wellbutrin]]
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| * [[Wellbutrin SR]]
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| * [[Wellbutrin XL]]
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| * [[Xanax]]
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| * [[Xanax XR]]
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| * [[Xyzal]]
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| * [[Xyzall]]
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| * [[zaleplon]]
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| * [[Zaponex]]
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| * [[Zestril]]
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| * [[Zetran]]
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| * [[ziprasidone]]
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| * [[Zoloft]]
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| * [[zolpidem]]
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| * [[zolpidem extended release]]
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| * [[Zonalon]]
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| * [[Zyban]]
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| * [[Zyban Advantage Pack]]
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| * [[Zyprexa]]
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| * [[Zyprexa Zydis]]
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| * [[Zyrtec]]
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| * [[Zyrtec Hives]]
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| {{refend}}
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| ==Minor Interactions==
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| {{refbegin|3}}
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| * [[apraclonidine ophthalmic]]
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| * [[Atapryl]]
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| * [[Azilect]]
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| * [[Carbex]]
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| * [[Eldepryl]]
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| * [[Emsam]]
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| * [[furazolidone]]
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| * [[Furoxone]]
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| * [[Iopidine]]
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| * [[isocarboxazid]]
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| * [[Jumex]]
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| * [[linezolid]]
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| * [[Marplan]]
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| * [[Matulane]]
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| * [[Nardil]]
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| * [[omeprazole]]
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| * [[Parnate]]
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| * [[phenelzine]]
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| * [[Prilosec]]
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| * [[Prilosec OTC]]
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| * [[procarbazine]]
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| * [[rasagiline]]
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| * [[selegiline]]
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| * [[Selgene]]
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| * [[tranylcypromine]]
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| * [[Zegerid (Original Formulation)]]
| |
| * [[Zelapar]]
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| * [[Zyvox]]
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| {{refend}}
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| ==LABORATORY TEST INTERACTIONS==
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| Nitrates and nitrites may interfere with the Zlatkis-Zak color reaction, causing falsely low readings in serum cholesterol determinations.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ISOSORBIDE MONONITRATE TABLET [ZYDUS PHARMACEUTICALS (USA) INC.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=897a0327-25d4-4769-bd6a-0e674264017f | publisher = | date = | accessdate = 30 January 2014}}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Drugs]]
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| {{FDA}}
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| [[Category:Drugs]]
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