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| __NOTOC__
| | #REDIRECT [[Aminocaproic acid#Overdosage]] |
| {{Aminocaproic acid}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Overdosage==
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| A few cases of acute overdosage with AMICAR administered intravenously have been reported. The effects have ranged from no reaction to transient [[hypotension]] to severe acute renal failure leading to death. One patient with a history of brain tumor and seizures experienced seizures after receiving an 8 gram bolus injection of AMICAR. The single dose of AMICAR causing symptoms of overdosage or considered to be life-threatening is unknown. Patients have tolerated doses as high as 100 grams while acute renal failure has been reported following a dose of 12 grams.
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| The intravenous and oral LD50 of AMICAR were 3.0 and 12.0 g/kg, respectively, in the mouse and 3.2 and 16.4 g/kg, respectively, in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog. On intravenous administration, tonic-clonic [[convulsions]] were observed in dogs and mice.
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| No treatment for overdosage is known, although evidence exists that AMICAR is removed by [[hemodialysis]] and may be removed by [[peritoneal dialysis]]. Pharmacokinetic studies have shown that total body clearance of AMICAR is markedly decreased in patients with severe renal failure.<ref>{{Cite web | last = | first = | title = DailyMed: Search | url = http://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Aminocaproic+acid&x=-1148&y=-229 | publisher = | date = | accessdate = 31 January 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antifibrinolytics]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Amino acids]]
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| [[Category:Antifibrinolytics]]
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| [[Category:Hematology]]
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| [[ja:Ε-アミノカプロン酸]]
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| [[pl:Kwas ε-aminokapronowy]]
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