Thrombocytopenia causes: Difference between revisions

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__NOTOC__
__NOTOC__
{{Thrombocytopenia}}
{{Thrombocytopenia}}
{{CMG}}; {{AE}} {{Ochuko}}
{{CMG}}; {{AE}} {{Ochuko}}, [https://www.wikidoc.org/index.php/User:Farbod_Zahedi_Tajrishi <nowiki>Farbod Zahedi Tajrishi, M.D. [2]</nowiki>]


==Overview==
==Overview==
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===Causes by Organ System===
===Causes by Organ System===
{| style="width:80%; height:100px" border="1"
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
| style="width:75%" bgcolor="Beige" ; border="1" | [[Disseminated intravascular coagulation]], [[endocarditis]], [[pulmonary embolism]]
|-
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
| bgcolor="Beige" | [[Strontium-89]],[[zinc]]
|-
|- bgcolor="LightSteelBlue"
| '''Dental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| bgcolor="Beige" | [[Cholesterol embolism]], [[Elejalde syndrome]], [[Griscelli syndrome|Griscelli syndrome type 1]], [[neuroectodermal melanolysosomal disease]], [[post-transfusion purpura]]
|-
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| bgcolor="Beige" |  [[Ado-trastuzumab emtansine]], [[albendazole]], [[alemtuzumab]], [[altretamine]], [[amiodarone]], [[Amoxicillin]], [[amphotericin B]], [[amrinone]], [[amsacrine]], [[anagrelide]], [[anazolene]], [[anti-thymocyte globulin]], [[ardeparin]], [[Asenapine maleate]], [[Aspirin]], [[azathioprine]], [[Azacitidine]], [[Aztreonam]], [[bendamustine]], [[benoxaprofen]], [[Beractant]], [[bevacizumab]], [[Boceprevir]], [[bortezomib]], [[bosutinib]], [[brentuximab vedotin]], [[cabazitaxel]],  [[Cabozantinib]], [[capecitabine]], [[captopril]], [[carboplatin]], [[carfilzomib]], [[carmustine]], [[caspofungin]], [[Cefadroxil]], [[Cefepime]], [[Cefotaxime sodium]], [[Ceftazidime]],  [[Cefaclor]], [[Certolizumab pegol]], [[Chlorpropamide]] , [[chlorambucil]], [[chloramphenicol]],[[clofarabine]],  [[Cidofovir]], [[cilazapril]], [[cimetidine]], [[cisplatin]], [[cladribine]], [[Clemastine]], [[clofarabine]], [[Clobazam]], [[Cyclophosphamide]], [[Cytarabine]], [[cytosine arabinoside]], [[dacarbazine]], [[Dactinomycin]], [[dasatinib]], [[daunorubicin]], [[decitabine]], [[deferasirox]], [[desferrioxamine]], [[Desmopressin]], [[Dexchlorpheniramine]], [[Dexrazoxane]], [[Dextran]] [[Didanosine]], [[diflunisal]], [[docetaxel]], [[Doxorubicin Hydrochloride]], [[doxycycline]], [[Rifampin]] [[platelet|drug-induced thrombocytopenia]], [[efalizumab]], [[eflornithine]], [[Eltrombopag]], [[enoxaparin]], [[Epirubicin hydrochloride]], [[eptifibatide]], [[Eribulin]], [[Ethambutol]], [[Ethacrynic Acid]], [[etoposide]], [[everolimus]], [[febuxostat]], [[Felbamate]], [[Filgastrim]], [[flucytosine]], [[fludarabine]], [[fluorouracil]], [[fondaparinux]], [[foscarnet]], [[ganciclovir]], [[gemcitabine]], [[gemtuzumab ozogamicin]], [[glycoprotein IIb/IIIa inhibitors]], [[gold salts]], [[guanidinium]], [[Guanidine]], [[haem arginate]], [[heparin]], [[Hydrocodone bitartrate and acetaminophen]], [[hydroxycarbamide]], [[hydroxychloroquine]], [[Hydroxyurea (patient information)]], [[ibitumomab tiuxetan]], [[ibuprofen lysine]], [[ibrutinib]], [[idarubicin]], [[ifosfamide]], [[imatinib mesylate]], [[Indinavir]], [[indomethacin]], [[integrilin]], [[interferon alpha]], [[interferon alfacon-1]], [[Imipenem-Cilastatin]],[[Interferon beta- 1a]],  [[Interferon gamma]], [[interleukin 10]], [[interleukin 2]], [[irinotecan hydrochloride]], [[Isoniazid]], [[isotretinoin]], [[ixabepilone]], [[Lapatinib]],[[lenalidomide]], [[Letrozole]], [[linezolid]], [[lomustine]], [[low molecular weight heparin]]s, [[Loxapine]], [[melphalan]], [[mercaptopurine]], [[Meropenem]], [[methimazole]], [[methotrexate]], [[methyldopa]], [[methyldopate]], [[methylphenidate]], [[micafungin sodium]], [[Milnacipran hydrochloride]], [[minocycline hydrochloride]], [[miltefosine]], [[mithramycin]], [[mitomycin]], [[mitoxantrone]], [[MMR vaccine]], [[montelukast]], [[nabumetone]], [[nelarabine]], [[niacin]], [[nilotinib]], [[nitisinone]], [[Nizatidine]], [[obinutuzumab]], [[Ofatumumab]], [[Omacetaxine]], [[omacetaxine mepesuccinate]], [[Olsalazine]], [[oxaliplatin]], [[Oxaprozin]], [[oxcarbazepine]], [[Oxytetracycline]], [[paclitaxel]], [[Palbociclib]], [[panobinostat]], [[para-amino salicylic acid]], [[pazopanib]], [[Pegademase]], [[Peginterferon Beta-1a]],[[pemetrexed]], [[penicillamine]], [[pentamidine Isethionate]], [[pentostatin]],  [[phenylbutazone]], [[phenytoin]], [[Pergolide]], [[Pertuzumab]], [[pixantrone]], [[Plerixafor]], [[pomalidomide]], [[ponatinib]], [[pralatrexate]], [[pramipexole]], [[procarbazine]], [[promethazine]], [[proton pump inhibitors]], [[pyrimethamine]], [[quinidine]], [[quinine]], [[Rabeprazole]], [[Radium chloride]], [[raltitrexed]], [[ranitidine]], [[regorafenib]], [[reoPro]], [[repaglinide]], [[rifampicin]], [[Ritonavir]], [[rituximab]], [[romidepsin]], [[Romiplostim]], [[ruxolitinib]], [[Siltuximab]], [[sirolimus]], [[Sodium aurothiomalate]], [[sorafenib]], [[stiripentol]], [[Streptozocin]], [[Sulfacetamide]], [[Sulfamethoxazole/Trimethoprim (oral)]], [[sulfasalazine]], [[sulindac]], [[sulfonamides]], [[sunitinib malate]], [[Spironolactone]], [[Tacrolimus]], [[Tamoxifen]], [[temozolomide]], [[temsirolimus]], [[teniposide]], [[thalidomide]], [[thioguanine]], [[thiotepa]], [[Thiothixene]], [[Tiagabine]], [[ticlopidine]], [[tinzaparin]], [[tirofiban]],  [[tocilizumab]], [[topotecan]], [[Tolmetin]], [[Tolazamide]], [[Toremifene]], [[tositumomab iodine-131]], [[trabectedin]], [[Trimethadione]], [[trimethoprim-sulfamethoxazole]], [[tolbutamide]], [[valganciclovir]], [[valproic acid]], [[vancomycin]], [[Vinblastine]], [[Vincristine sulfate liposome]] [[vinflunine]], [[vinorelbine]], [[vorinostat]], [[ziv-aflibercept]], [[zonisamide]]
|-
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| bgcolor="Beige" | [[Alport syndrome]], [[Arias oculootoradial syndrome]], [[Epstein's syndrome]], [[Fechtner syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| bgcolor="Beige" | [[Immunodysregulation polyendocrinopathy and enteropathy, X-linked]]
|-
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| bgcolor="Beige" | [[aminoaciduria|Dibasic aminoaciduria type 2]], [[liver failure]], [[Niemann-Pick disease|Niemann-Pick disease type b]], [[portal hypertension]], [[Shwachman-Diamond syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| bgcolor="Beige" | [[Aicardi-Goutieres syndrome]], [[Alport syndrome]], [[Chediak-Higashi disease]], [[factor H|complement factor H deficiency]], [[Elejalde syndrome]], [[Fanconi anaemia]], [[Fechtner syndrome]], [[Griscelli syndrome|Griscelli syndrome type 1]], [[holocarboxylase synthase deficiency]], [[iminodipeptiduria]], [[Jacobsen syndrome]], [[MELAS]], [[neuroectodermal melanolysosomal disease]], [[Niemann-Pick disease|Niemann-Pick disease type b]], [[Omenn syndrome]], [[Paris-Trousseau thrombocytopenia]], [[Shwachman-Diamond syndrome]], [[TAR syndrome]], [[TAR syndrome|Thrombocytopenia absent radius syndrome]], [[Von Willebrand disease|Von Willebrand disease, platelet type]], [[Wiskott-Aldrich syndrome]], [[X-linked hyperimmunoglobulin M syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| bgcolor="Beige" | [[Acquired pure megakaryocytic aplasia]], [[aplastic anemia]], [[Bernard-Soulier syndrome]], [[thrombocytopenia|congenital amegakaryocytic thrombocytopenia (CAMT)]], [[disseminated intravascular coagulation]], [[Epstein's syndrome]], [[familial histiocytic reticulosis]], [[Gasser syndrome]], [[GATA1|GATA1-related cytopenia]], [[Glanzmann's thrombasthenia]], [[grey platelet syndrome]], [[hemolytic uremic syndrome]], [[histiocytosis X]], [[hypersplenism]], [[idiopathic thrombocytopenic purpura]], [[Jacobsen syndrome]], [[Kasabach-Merritt syndrome]], [[May-Hegglin anomaly]], [[Moschcowitz syndrome]], [[myelodysplastic syndrome]], [[myelofibrosis]], [[neonatal alloimmune thrombocytopenia]], [[pancytopenia]], [[Paris-Trousseau thrombocytopenia]], [[paroxysmal nocturnal hemoglobinuria]], [[post-transfusion purpura]], [[pulmonary embolism]], [[TAR syndrome|radial aplasia-thrombocytopenia syndrome]], [[Sebastian platelet syndrome]], [[Shwachman-Diamond syndrome]], [[thrombotic thrombocytopenic purpura]], [[Von Willebrand disease|Von Willebrand disease, platelet type]], [[Werlhof disease]], [[Wiskott-Aldrich syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| bgcolor="Beige" | [[coronary artery bypass surgery|Cardiac bypass]], [[chemotherapy]], [[intra-aortic balloon pump|intra-aortic balloon pump placement]], [[blood transfusion|massive blood transfusion]], [[radiation therapy]]
|-
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| bgcolor="Beige" | [[Congenital syphilis]], [[cytomegalovirus]], [[Dengue fever]], [[ehrlichiosis]], [[Epstein-Barr virus]], [[hantavirus]], [[hepatitis C]], [[HIV]], [[human granulocytic ehrlichiosis]], [[ehrlichiosis|human monocytotropic ehrlichiosis]], [[infections]], [[infectious mononucleosis]], [[lassa fever]], [[leptospirosis]], [[malaria]], [[measles]], [[mumps]], [[mycoplasma pneumonia]], [[relapsing fever|Oklahoma tick fever]], [[parvovirus]], [[Q fever]], [[rubella]], [[septicaemia]], [[tick-borne encephalitis]], [[toxic shock syndrome|toxic shock syndrome (staphylococcal)]], [[varicella]], [[visceral leishmaniasis]]
|-
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| bgcolor="Beige" | [[Arias oculootoradial syndrome]], [[cholesterol embolism]], [[TAR syndrome|radial aplasia-thrombocytopenia syndrome]], [[TAR syndrome]], [[TAR syndrome|thrombocytopenia absent radius syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| bgcolor="Beige" | [[Aicardi-Goutieres syndrome]], [[Jacobsen syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| bgcolor="Beige" | [[aminoaciduria|Dibasic aminoaciduria type 2]], [[folate deficiency]], [[Gaucher disease]], [[holocarboxylase synthase deficiency]], [[iminodipeptiduria]], [[iron deficiency]], [[isovaleric acidaemia]], [[methylmalonic aciduria|methylmalonic aciduria type 2]], [[CD36|platelet glycoprotein 4 deficiency]], [[platelet glycoprotein Ib deficiency]], [[prolidase deficiency]], [[propionyl-CoA carboxylase deficiency]], [[sea blue histiocytosis]], [[sitosterolemia]], [[vitamin B12 deficiency]]
|-
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| bgcolor="Beige" | [[Eclampsia]], [[HELLP syndrome]], [[pre-eclampsia]]
|-
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| bgcolor="Beige" | [[Acute lymphoblastic leukemia]], [[acute myeloid leukemia]], [[acute promyelocytic leukemia]], [[chronic lymphocytic leukaemia]], [[chronic myeloid leukaemia]], [[hairy cell leukaemia]], [[hepatosplenic T-cell lymphoma]], [[histiocytosis X]], [[Kasabach-Merritt syndrome]], [[lymphoma]], [[myeloma]], [[Non-Hodgkins lymphoma]], [[paraneoplastic syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| bgcolor="Beige" | [[Arias oculootoradial syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| bgcolor="Beige" | [[Alcohol]], [[arsenic trioxide]], [[ethanol]]
|-
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| bgcolor="Beige" | [[Acute respiratory distress syndrome]], [[Niemann-Pick disease|Niemann-Pick disease type b]], [[pulmonary embolism]]
|-
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| bgcolor="Beige" | [[Alport syndrome]], [[cholesterol embolism]], [[aminoaciduria|Dibasic aminoaciduria type 2]], [[Epstein's syndrome]], [[Fechtner syndrome]], [[hemolytic uremic syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| bgcolor="Beige" | [[Anticardiolipin syndrome]], [[antiphospholipid syndrome]], [[autoimmune lymphoproliferative syndrome type 1]], [[autoimmune lymphoproliferative syndrome type 2]], [[factor H|complement factor H deficiency]], [[Evans syndrome]], [[immunodysregulation polyendocrinopathy and enteropathy, X-linked]], [[macrophage-activation syndrome]], [[neonatal alloimmune thrombocytopenia]], [[Omenn syndrome]], [[paraneoplastic syndrome]], [[systemic lupus erythematosus]], [[Wiskott-Aldrich syndrome]], [[X-linked hyperimmunoglobulin M syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| bgcolor="Beige" | [[Snakebites]]
|-
|}


===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
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*[[Acute promyelocytic leukemia]]
*[[Acute promyelocytic leukemia]]
*[[Acute respiratory distress syndrome]]
*[[Acute respiratory distress syndrome]]
*[[Ado-trastuzumab emtansine]]
*[[Aflibercept]]
*[[Aflibercept]]
*[[Aggrastat]]
*[[Aggrastat]]
*[[Aicardi goutieres syndrome]]
*[[Aicardi-Goutieres syndrome]]
*[[Albendazole]]
*[[Albendazole]]
*[[Alcohol]]
*[[Alcohol]]
Line 58: Line 171:
*[[Altretamine]]
*[[Altretamine]]
*[[Amiodarone]]
*[[Amiodarone]]
*[[Amoxicillin]]
*[[Amphotericin B]]
*[[Amphotericin B]]
*[[Amrinone]]
*[[Amrinone]]
Line 65: Line 179:
*[[Anticardiolipin syndrome]]
*[[Anticardiolipin syndrome]]
*[[Antiphospholipid syndrome]]
*[[Antiphospholipid syndrome]]
*[[Antithymocyte globulin]]
*[[Anti-thymocyte globulin]]
*[[Aplastic anemia]]  
*[[Aplastic anemia]]  
*[[Ardeparin]]
*[[Ardeparin]]
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*[[Autoimmune lymphoproliferative syndrome type 2]]
*[[Autoimmune lymphoproliferative syndrome type 2]]
*[[Azathioprine]]
*[[Azathioprine]]
*[[Aztreonam]]
*[[Bendamustine]]  
*[[Bendamustine]]  
*[[Benoxaprofen]]
*[[Benoxaprofen]]
*[[Bernard-Soulier syndrome]]
*[[Bernard-Soulier syndrome]]
*[[Bevacizumab]]
*[[Bevacizumab]]
*[[Boceprevir]]
*[[Bortezomib]]
*[[Bortezomib]]
*[[Bosutinib]]
*[[Bosutinib]]
Line 84: Line 200:
*[[Captopril]]
*[[Captopril]]
*[[Carboplatin]]
*[[Carboplatin]]
*[[Cardiac bypass]]  
*[[coronary artery bypass surgery|Cardiac bypass]]  
*[[Carfilzomib]]
*[[Carfilzomib]]
*[[Carmustine]]
*[[Carmustine]]
*[[Caspofungin]]  
*[[Caspofungin]]  
*[[Cefadroxil]]
*[[Cefepime]]
*[[Cefotaxime sodium]]
*[[Ceftazidime]]
*[[Chediak-Higashi disease]]
*[[Chediak-Higashi disease]]
*[[Chemotherapy]]
*[[Chemotherapy]]
*[[Chlorambucil]]
*[[Chlorambucil]]
*[[Chloramphenicol]]
*[[Chloramphenicol]]
*[[Chlorpropamide]]
*[[Cholesterol embolism]]
*[[Cholesterol embolism]]
*[[Chronic lymphocytic leukaemia]]
*[[Chronic lymphocytic leukaemia]]
*[[Chronic myeloid leukaemia]]
*[[Chronic myeloid leukaemia]]
*[[Cidofovir]]
*[[Cilazapril]]
*[[Cilazapril]]
*[[Cimetidine]]  
*[[Cimetidine]]  
Line 101: Line 223:
*[[Clofarabine]]
*[[Clofarabine]]
*[[factor H|Complement factor H deficiency]]  
*[[factor H|Complement factor H deficiency]]  
*[[Congenital amegakaryocytic thrombocytopenia (CAMT)]]  
*[[thrombocytopenia|Congenital amegakaryocytic thrombocytopenia (CAMT)]] 
*[[Cyclophosphamide]]
*[[Cytomegalovirus]]  
*[[Cytomegalovirus]]  
*[[Cytarabine]]
*[[Cytosine arabinoside]]  
*[[Cytosine arabinoside]]  
*[[Dacarbazine]]
*[[Dacarbazine]]
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*[[Dengue fever]]
*[[Dengue fever]]
*[[Desferrioxamine]]
*[[Desferrioxamine]]
*[[Desmopressin]]
*[[aminoaciduria|Dibasic aminoaciduria type 2]]
*[[aminoaciduria|Dibasic aminoaciduria type 2]]
{{col-break|width=33%}}
*[[Didanosine]]
*[[Disseminated intravascular coagulation]]
*[[Disseminated intravascular coagulation]]
*[[Docetaxel]]
*[[Docetaxel]]
*[[Doxorubicin]]
*[[Doxorubicin Hydrochloride]]
*[[Drug-induced thrombocytopenia]]
*[[platelet|Drug-induced thrombocytopenia]]
{{col-break|width=33%}}
*[[Eclampsia]]
*[[Eclampsia]]
*[[Efalizumab]]
*[[Efalizumab]]
*[[Eflornithine]]
*[[Eflornithine]]
*[[Ehrlichiosis]]
*[[Ehrlichiosis]]
*[[Elejalde syndrome - neuroectodermal melanolysosomal disease]]  
*[[Elejalde syndrome]]  
*[[Endocarditis]]  
*[[Endocarditis]]  
*[[Enoxaparin]]
*[[Enoxaparin]]
*[[Epirubicin]]  
*[[Epirubicin hydrochloride]]  
*[[Epstein syndrome]]
*[[Epstein's syndrome]]
*[[Epstein-Barr virus]]  
*[[Epstein-Barr virus]]  
*[[Eptifibatide]]
*[[Eptifibatide]]
*[[Eribulin]]
*[[Ethanol]]  
*[[Ethanol]]  
*[[Etoposide]]
*[[Etoposide]]
Line 134: Line 261:
*[[Fanconi anaemia]]
*[[Fanconi anaemia]]
*[[Fechtner syndrome]]
*[[Fechtner syndrome]]
*[[Flucytocine]]
*[[Filgastrim]]
*[[Flucytosine]]
*[[Fludarabine]]
*[[Fludarabine]]
*[[Fluorouracil]]
*[[Fluorouracil]]
Line 142: Line 270:
*[[Ganciclovir]]
*[[Ganciclovir]]
*[[Gasser syndrome]]  
*[[Gasser syndrome]]  
*[[GATA1-related cytopenia]]
*[[GATA1|GATA1-related cytopenia]]
*[[Gaucher disease]]
*[[Gaucher disease]]
*[[Gemcitabine]]
*[[Gemcitabine]]
Line 150: Line 278:
*[[Gold salts]]  
*[[Gold salts]]  
*[[Grey platelet syndrome]]
*[[Grey platelet syndrome]]
*[[Griscelli syndrome type 1]]  
*[[Griscelli syndrome|Griscelli syndrome type 1]]  
*[[Guanidinium]]  
*[[Guanidinium]]  
*[[Haem arginate]]
*[[Haem arginate]]
Line 164: Line 292:
*[[Holocarboxylase synthase deficiency]]
*[[Holocarboxylase synthase deficiency]]
*[[Human granulocytic ehrlichiosis]]
*[[Human granulocytic ehrlichiosis]]
*[[Human monocytotropic ehrlichiosis]]
*[[ehrlichiosis|Human monocytotropic ehrlichiosis]]
*[[Hydroxycarbamide]]
*[[Hydroxycarbamide]]
*[[Hydroxyurea (patient information)]]
*[[Hypersplenism]]
*[[Hypersplenism]]
*[[Ibritumomab tiuxetan]]
*[[Ibritumomab tiuxetan]]
*[[Ibrutinib]]
*[[Ibrutinib]]
*[[Ibuprofen lysine]]
*[[Idarubicin]]
*[[Idarubicin]]
*[[Idiopathic thrombocytopenic purpura]]
*[[Idiopathic thrombocytopenic purpura]]
Line 175: Line 305:
*[[Iminodipeptiduria]]
*[[Iminodipeptiduria]]
*[[Immunodysregulation polyendocrinopathy and enteropathy, X-linked]]
*[[Immunodysregulation polyendocrinopathy and enteropathy, X-linked]]
*[[Indinavir]]
*[[Indomethacin]]
*[[Indomethacin]]
*[[Infections]]
*[[Infections]]
*[[Infectious mononucleosis]]
*[[Infectious mononucleosis]]
*[[Infliximab]]
*[[Integrilin]]
*[[Integrilin]]
*[[Interferon alpha]]  
*[[Interferon alpha]]  
*[[Interferon gamma]]
*[[Interleukin 10]]
*[[Interleukin 10]]
*[[Interleukin 2]]
*[[Interleukin 2]]
*[[Intra-aortic balloon pump placement]]
*[[intra-aortic balloon pump|Intra-aortic balloon pump placement]]
{{col-break|width=33%}}
*[[Irinotecan hydrochloride]]
*[[Irinotecan]]
*[[Iron deficiency]]
*[[Iron deficiency]]
*[[Isoniazid]]
*[[Isotretinoin]]
*[[Isotretinoin]]
*[[Isovaleric acidaemia]]
*[[Isovaleric acidaemia]]
Line 193: Line 326:
*[[Lassa fever]]
*[[Lassa fever]]
*[[Lenalidomide]]
*[[Lenalidomide]]
{{col-break|width=33%}}
*[[Leptospirosis]]
*[[Leptospirosis]]
*[[Linezolid]]
*[[Linezolid]]
*[[Liver failure]]
*[[Liver failure]]
*[[Lomustine]]
*[[Lomustine]]
*[[Low molecular weight heparins]]
*[[Low molecular weight heparin]]s
*[[Lymphoma]]
*[[Lymphoma]]
*[[Macrophage-activation syndrome]]
*[[Macrophage-activation syndrome]]
Line 212: Line 346:
*[[methylmalonic aciduria|Methylmalonic aciduria type 2]]
*[[methylmalonic aciduria|Methylmalonic aciduria type 2]]
*[[Methylphenidate]]
*[[Methylphenidate]]
*[[Micafungin]]
*[[Micafungin sodium]]
*[[Milnacipran hydrochloride]]
*[[Mithramycin]]  
*[[Mithramycin]]  
*[[Mitomycin C]]
*[[Mitomycin C]]
Line 228: Line 363:
*[[Neuroectodermal melanolysosomal disease]]
*[[Neuroectodermal melanolysosomal disease]]
*[[Niacin]]
*[[Niacin]]
*[[niemann-pick disease|Niemann-Pick disease type b]]
*[[Niemann-Pick disease|Niemann-Pick disease type b]]
*[[Nilotinib]]
*[[Nilotinib]]
*[[Nitisinone]]
*[[Nitisinone]]
*[[Non-hodgkins lymphoma]]
*[[Non-Hodgkins lymphoma]]
*[[Obinutuzumab]]
*[[Obinutuzumab]]
*[[Oklahoma tick fever]]  
*[[relapsing fever|Oklahoma tick fever]]  
*[[Omacetaxine mepesuccinate]]  
*[[Omacetaxine mepesuccinate]]  
*[[Omenn syndrome]]
*[[Omenn syndrome]]
*[[Oxaliplatin]]
*[[Oxaliplatin]]
*[[Oxaprozin]]
*[[Paclitaxel]]  
*[[Paclitaxel]]  
*[[Palbociclib]]
*[[Pancytopenia]]
*[[Pancytopenia]]
*[[Panobinostat]]
*[[Panobinostat]]
Line 246: Line 383:
*[[Parvovirus]]
*[[Parvovirus]]
*[[Pazopanib]]
*[[Pazopanib]]
*[[Peginterferon Beta-1a]]
*[[Pemetrexed]]
*[[Pemetrexed]]
*[[Penicillamine]]  
*[[Penicillamine]]  
*[[Pentamidine]]
*[[Pentamidine]]
*[[Pentostatin]]
*[[Pentostatin]]
*[[Pergolide]]
*[[Phenylbutazone]]
*[[Phenylbutazone]]
*[[Phenytoin]]
*[[Phenytoin]]
*[[Pixantrone]]
*[[Pixantrone]]
*[[Platelet glycoprotein 4 deficiency]]
*[[CD36|Platelet glycoprotein 4 deficiency]]
*[[Platelet glycoprotein Ib deficiency]]
*[[Platelet glycoprotein Ib deficiency]]
*[[Plerixafor]]
*[[Pomalidomide]]  
*[[Pomalidomide]]  
*[[Ponatinib]]
*[[Ponatinib]]
{{col-break|width=33%}}
*[[Portal hypertension]]
*[[Portal hypertension]]
*[[Post-transfusion purpura]]  
*[[Post-transfusion purpura]]
*[[Pralatrexate]]
*[[Pralatrexate]]
*[[Pre-eclampsia]]  
*[[Pre-eclampsia]]  
Line 271: Line 410:
*[[Quinidine]]
*[[Quinidine]]
*[[Quinine]]
*[[Quinine]]
*[[Radial aplasia-thrombocytopenia syndrome]]
*[[TAR syndrome|Radial aplasia-thrombocytopenia syndrome]]
{{col-break|width=33%}}
*[[Radiation therapy]]
*[[Radiation therapy]]
*[[Radium chloride]]
*[[Raltitrexed]]
*[[Raltitrexed]]
*[[Ranitidine]]
*[[Ranitidine]]
Line 286: Line 427:
*[[Septicaemia]]  
*[[Septicaemia]]  
*[[Shwachman-Diamond syndrome]]
*[[Shwachman-Diamond syndrome]]
*[[Siltuximab]]
*[[Sirolimus]]
*[[Sirolimus]]
*[[Sitosterolemia]]  
*[[Sitosterolemia]]  
Line 291: Line 433:
*[[Sorafenib]]
*[[Sorafenib]]
*[[Stiripentol]]
*[[Stiripentol]]
*[[Streptozocin]]
*[[Strontium-89]]
*[[Strontium-89]]
*[[Sulfasalazine]]
*[[Sulfasalazine]]
*[[Sulfonamides]]
*[[Sulfonamides]]
*[[Sunitinib malate]]
*[[Sunitinib malate]]
*[[Syphilis (congenital)]]  
*[[Congenital syphilis]]  
*[[Systemic lupus erythematosus]]
*[[Systemic lupus erythematosus]]
*[[Tacrolimus]]
*[[Tamoxifen]]
*[[TAR syndrome]]  
*[[TAR syndrome]]  
*[[Temozolomide]]
*[[Temozolomide]]
Line 305: Line 450:
*[[thrombocytopenia absent radius|Thrombocytopenia absent radius syndrome]]
*[[thrombocytopenia absent radius|Thrombocytopenia absent radius syndrome]]
*[[Thrombotic thrombocytopenic purpura]]  
*[[Thrombotic thrombocytopenic purpura]]  
*[[Tick borne encephalitis]]
*[[Tiagabine]]
*[[Tick-borne encephalitis]]
*[[Ticlopidine]]
*[[Ticlopidine]]
*[[Tinzaparin]]
*[[Tinzaparin]]
Line 331: Line 477:
{{col-end}}
{{col-end}}


==References==
{{Reflist|2}}


=====Mendelian inherited conditions=====
[[Category:Crowdiagnosis]]
*Autoimmune lymphoproliferative syndrome type 1
[[Category:Hematology]]
*Autoimmune lymphoproliferative syndrome type 2
*Radial aplasia-thrombocytopenia syndrome or [[Thrombocytopenia absent radius]] syndrome
*[[von Willebrand disease]], platelet type
 
=====Autosomal dominant conditions=====
*Arias oculootoradial syndrome
*Complement [[factor H|factor H deficiency]]
*[[Fechtner syndrome]]
*[[May-Hegglin anomaly]]
*Platelet glycoprotein 4 deficiency
*[[Sebastian platelet syndrome]]
 
=====Autosomal recessive conditions=====
*[[Chediak-Higashi disease]]
*Dibasic [[aminoaciduria]] type 2
*Familial [[histiocytic reticulosis]]
*[[Fanconi anaemia]]
*[[Folate]] malabsorption hereditary
*[[Gaucher disease]]
*[[Griscelli syndrome]] type 1
*[[Histiocytosis X]]
*[[Holocarboxylase synthase deficiency]]
*[[Iminodipeptiduria]]
*[[Isovaleric acidaemia]]
*[[Methylmalonic aciduria]] type 2
*Neuroectodermal melanolysosomal disease
*[[Niemann-Pick disease]] type B
*[[Omenn syndrome]]
*[[Platelet glycoprotein Ib deficiency]]
*[[Propionyl-CoA carboxylase deficiency]] PCCA type
*[[Sea blue histiocytosis]]
*[[Shwachman-Diamond syndrome]]
 
==Medication-induced==
Thrombocytopenia associated with medications can be due to either a reduction in production of platelets or increased destruction.
=====List of potential etiologies:=====
{{col-begin}}
{{col-break}}
 
[[Low molecular weight heparin]]s
 
Sulphonamides
 
Drugs, hormones and mediators
 
[[5-Azacytidine]]
 
[[Abciximab]]
 
Aclarubicin
 
[[Actinomycin D]]
 
[[Aggrastat]]
 
[[Albendazole]]
 
[[Alemtuzumab]]
 
[[Altretamine]]
 
[[Amiodarone]]
 
[[Amrinone]]
 
[[Anagrelide]]
 
Anazolene
 
Antithymocyte globulin
 
[[Ardeparin]]
 
[[Arsenic]] trioxide
 
[[Azathioprine]]
 
[[Bendamustine]]
 
[[Benoxaprofen]]
 
[[Bortezomib]]
 
[[Captopril]]
 
[[Caspofungin]]
 
[[Chloramphenicol]]
 
[[Cilazapril]]
 
[[Cimetidine]]
 
[[Cladribine]]
 
[[Clofarabine]]
 
[[Dasatinib]]
 
[[Decitabine]]
 
[[Desferrioxamine]]
 
[[Doxorubicin]]
 
[[Efalizumab]]
 
{{col-break}}
 
[[Eflornithine]]
 
[[Epirubicin]]
 
[[Eptifibatide]]
 
[[Ethanol]]
 
[[Flucytosine]]
 
[[Fondaparinux]]
 
[[Ganciclovir]]
 
[[Gemcitabine]]
 
[[Gemtuzumab ozogamicin]]
 
[[Gold salts]]
 
Guanidinium
 
Haem arginate
 
[[Heparin]]
 
[[Ibritumomab tiuxetan]]
 
[[Idarubicin]]
 
[[Imatinib mesylate]]
 
[[Indomethacin]]
 
[[Integrilin]]
 
[[Interferon alpha]]


[[Interleukin 10]]
{{WH}}
 
{{WS}}
[[Interleukin 2]]
 
[[Irinotecan]]
 
[[Ixabepilone]]
 
[[Lenalidomide]]
 
[[Lomustine]]
 
[[Melphalan]]
 
[[Mercaptopurine]]
 
[[Methyldopa]]
 
Methyldopate
 
[[Mithramycin]]
 
[[Nelarabine]]
 
[[Nilotinib]]
 
{{col-break}}
[[Nitisinone]]
 
[[Oxaliplatin]]
 
Para-amino [[salicylic acid]]
 
[[Pemetrexed]]
 
[[Penicillamine]]
 
[[Pentamidine]]
 
[[Phenylbutazone]]
 
[[Pyrimethamine]]
 
[[Quinidine]]
 
[[Quinine]]
 
[[Ranitidine]]
 
[[ReoPro]]
 
[[Rifampicin]]
 
[[Sirolimus]]
 
[[Sorafenib]]
 
[[Stiripentol]]
 
Sulphasalazine
 
Sunitinib malate
 
[[Temozolomide]]
 
[[Ticlopidine]]
 
[[Tirofiban]]
 
[[Topotecan]]
 
[[Trabectedin]]
 
[[Trimetrexate]]
 
[[Valganciclovir]]
 
[[Valproic acid]]
 
[[Vancomycin]]
 
[[Vinorelbine]]
 
[[Vorinostat]]
 
|}
 
==References==
{{Reflist|2}}
[[Category:Needs content]]

Latest revision as of 21:43, 3 October 2018

Thrombocytopenia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2], Farbod Zahedi Tajrishi, M.D. [2]

Overview

There are two broad mechanisms for the causes of thrombocytopenia: Reduced platelet production and increased platelet destruction. Thrombocytopenia is seen in a variety of infectious and genetic disorders as well as a side effect of a large list of medications.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular Disseminated intravascular coagulation, endocarditis, pulmonary embolism
Chemical/Poisoning Strontium-89,zinc
Dental No underlying causes
Dermatologic Cholesterol embolism, Elejalde syndrome, Griscelli syndrome type 1, neuroectodermal melanolysosomal disease, post-transfusion purpura
Drug Side Effect Ado-trastuzumab emtansine, albendazole, alemtuzumab, altretamine, amiodarone, Amoxicillin, amphotericin B, amrinone, amsacrine, anagrelide, anazolene, anti-thymocyte globulin, ardeparin, Asenapine maleate, Aspirin, azathioprine, Azacitidine, Aztreonam, bendamustine, benoxaprofen, Beractant, bevacizumab, Boceprevir, bortezomib, bosutinib, brentuximab vedotin, cabazitaxel, Cabozantinib, capecitabine, captopril, carboplatin, carfilzomib, carmustine, caspofungin, Cefadroxil, Cefepime, Cefotaxime sodium, Ceftazidime, Cefaclor, Certolizumab pegol, Chlorpropamide , chlorambucil, chloramphenicol,clofarabine, Cidofovir, cilazapril, cimetidine, cisplatin, cladribine, Clemastine, clofarabine, Clobazam, Cyclophosphamide, Cytarabine, cytosine arabinoside, dacarbazine, Dactinomycin, dasatinib, daunorubicin, decitabine, deferasirox, desferrioxamine, Desmopressin, Dexchlorpheniramine, Dexrazoxane, Dextran Didanosine, diflunisal, docetaxel, Doxorubicin Hydrochloride, doxycycline, Rifampin drug-induced thrombocytopenia, efalizumab, eflornithine, Eltrombopag, enoxaparin, Epirubicin hydrochloride, eptifibatide, Eribulin, Ethambutol, Ethacrynic Acid, etoposide, everolimus, febuxostat, Felbamate, Filgastrim, flucytosine, fludarabine, fluorouracil, fondaparinux, foscarnet, ganciclovir, gemcitabine, gemtuzumab ozogamicin, glycoprotein IIb/IIIa inhibitors, gold salts, guanidinium, Guanidine, haem arginate, heparin, Hydrocodone bitartrate and acetaminophen, hydroxycarbamide, hydroxychloroquine, Hydroxyurea (patient information), ibitumomab tiuxetan, ibuprofen lysine, ibrutinib, idarubicin, ifosfamide, imatinib mesylate, Indinavir, indomethacin, integrilin, interferon alpha, interferon alfacon-1, Imipenem-Cilastatin,Interferon beta- 1a, Interferon gamma, interleukin 10, interleukin 2, irinotecan hydrochloride, Isoniazid, isotretinoin, ixabepilone, Lapatinib,lenalidomide, Letrozole, linezolid, lomustine, low molecular weight heparins, Loxapine, melphalan, mercaptopurine, Meropenem, methimazole, methotrexate, methyldopa, methyldopate, methylphenidate, micafungin sodium, Milnacipran hydrochloride, minocycline hydrochloride, miltefosine, mithramycin, mitomycin, mitoxantrone, MMR vaccine, montelukast, nabumetone, nelarabine, niacin, nilotinib, nitisinone, Nizatidine, obinutuzumab, Ofatumumab, Omacetaxine, omacetaxine mepesuccinate, Olsalazine, oxaliplatin, Oxaprozin, oxcarbazepine, Oxytetracycline, paclitaxel, Palbociclib, panobinostat, para-amino salicylic acid, pazopanib, Pegademase, Peginterferon Beta-1a,pemetrexed, penicillamine, pentamidine Isethionate, pentostatin, phenylbutazone, phenytoin, Pergolide, Pertuzumab, pixantrone, Plerixafor, pomalidomide, ponatinib, pralatrexate, pramipexole, procarbazine, promethazine, proton pump inhibitors, pyrimethamine, quinidine, quinine, Rabeprazole, Radium chloride, raltitrexed, ranitidine, regorafenib, reoPro, repaglinide, rifampicin, Ritonavir, rituximab, romidepsin, Romiplostim, ruxolitinib, Siltuximab, sirolimus, Sodium aurothiomalate, sorafenib, stiripentol, Streptozocin, Sulfacetamide, Sulfamethoxazole/Trimethoprim (oral), sulfasalazine, sulindac, sulfonamides, sunitinib malate, Spironolactone, Tacrolimus, Tamoxifen, temozolomide, temsirolimus, teniposide, thalidomide, thioguanine, thiotepa, Thiothixene, Tiagabine, ticlopidine, tinzaparin, tirofiban, tocilizumab, topotecan, Tolmetin, Tolazamide, Toremifene, tositumomab iodine-131, trabectedin, Trimethadione, trimethoprim-sulfamethoxazole, tolbutamide, valganciclovir, valproic acid, vancomycin, Vinblastine, Vincristine sulfate liposome vinflunine, vinorelbine, vorinostat, ziv-aflibercept, zonisamide
Ear Nose Throat Alport syndrome, Arias oculootoradial syndrome, Epstein's syndrome, Fechtner syndrome
Endocrine Immunodysregulation polyendocrinopathy and enteropathy, X-linked
Environmental No underlying causes
Gastroenterologic Dibasic aminoaciduria type 2, liver failure, Niemann-Pick disease type b, portal hypertension, Shwachman-Diamond syndrome
Genetic Aicardi-Goutieres syndrome, Alport syndrome, Chediak-Higashi disease, complement factor H deficiency, Elejalde syndrome, Fanconi anaemia, Fechtner syndrome, Griscelli syndrome type 1, holocarboxylase synthase deficiency, iminodipeptiduria, Jacobsen syndrome, MELAS, neuroectodermal melanolysosomal disease, Niemann-Pick disease type b, Omenn syndrome, Paris-Trousseau thrombocytopenia, Shwachman-Diamond syndrome, TAR syndrome, Thrombocytopenia absent radius syndrome, Von Willebrand disease, platelet type, Wiskott-Aldrich syndrome, X-linked hyperimmunoglobulin M syndrome
Hematologic Acquired pure megakaryocytic aplasia, aplastic anemia, Bernard-Soulier syndrome, congenital amegakaryocytic thrombocytopenia (CAMT), disseminated intravascular coagulation, Epstein's syndrome, familial histiocytic reticulosis, Gasser syndrome, GATA1-related cytopenia, Glanzmann's thrombasthenia, grey platelet syndrome, hemolytic uremic syndrome, histiocytosis X, hypersplenism, idiopathic thrombocytopenic purpura, Jacobsen syndrome, Kasabach-Merritt syndrome, May-Hegglin anomaly, Moschcowitz syndrome, myelodysplastic syndrome, myelofibrosis, neonatal alloimmune thrombocytopenia, pancytopenia, Paris-Trousseau thrombocytopenia, paroxysmal nocturnal hemoglobinuria, post-transfusion purpura, pulmonary embolism, radial aplasia-thrombocytopenia syndrome, Sebastian platelet syndrome, Shwachman-Diamond syndrome, thrombotic thrombocytopenic purpura, Von Willebrand disease, platelet type, Werlhof disease, Wiskott-Aldrich syndrome
Iatrogenic Cardiac bypass, chemotherapy, intra-aortic balloon pump placement, massive blood transfusion, radiation therapy
Infectious Disease Congenital syphilis, cytomegalovirus, Dengue fever, ehrlichiosis, Epstein-Barr virus, hantavirus, hepatitis C, HIV, human granulocytic ehrlichiosis, human monocytotropic ehrlichiosis, infections, infectious mononucleosis, lassa fever, leptospirosis, malaria, measles, mumps, mycoplasma pneumonia, Oklahoma tick fever, parvovirus, Q fever, rubella, septicaemia, tick-borne encephalitis, toxic shock syndrome (staphylococcal), varicella, visceral leishmaniasis
Musculoskeletal/Orthopedic Arias oculootoradial syndrome, cholesterol embolism, radial aplasia-thrombocytopenia syndrome, TAR syndrome, thrombocytopenia absent radius syndrome
Neurologic Aicardi-Goutieres syndrome, Jacobsen syndrome
Nutritional/Metabolic Dibasic aminoaciduria type 2, folate deficiency, Gaucher disease, holocarboxylase synthase deficiency, iminodipeptiduria, iron deficiency, isovaleric acidaemia, methylmalonic aciduria type 2, platelet glycoprotein 4 deficiency, platelet glycoprotein Ib deficiency, prolidase deficiency, propionyl-CoA carboxylase deficiency, sea blue histiocytosis, sitosterolemia, vitamin B12 deficiency
Obstetric/Gynecologic Eclampsia, HELLP syndrome, pre-eclampsia
Oncologic Acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, chronic lymphocytic leukaemia, chronic myeloid leukaemia, hairy cell leukaemia, hepatosplenic T-cell lymphoma, histiocytosis X, Kasabach-Merritt syndrome, lymphoma, myeloma, Non-Hodgkins lymphoma, paraneoplastic syndrome
Ophthalmologic Arias oculootoradial syndrome
Overdose/Toxicity Alcohol, arsenic trioxide, ethanol
Psychiatric No underlying causes
Pulmonary Acute respiratory distress syndrome, Niemann-Pick disease type b, pulmonary embolism
Renal/Electrolyte Alport syndrome, cholesterol embolism, Dibasic aminoaciduria type 2, Epstein's syndrome, Fechtner syndrome, hemolytic uremic syndrome
Rheumatology/Immunology/Allergy Anticardiolipin syndrome, antiphospholipid syndrome, autoimmune lymphoproliferative syndrome type 1, autoimmune lymphoproliferative syndrome type 2, complement factor H deficiency, Evans syndrome, immunodysregulation polyendocrinopathy and enteropathy, X-linked, macrophage-activation syndrome, neonatal alloimmune thrombocytopenia, Omenn syndrome, paraneoplastic syndrome, systemic lupus erythematosus, Wiskott-Aldrich syndrome, X-linked hyperimmunoglobulin M syndrome
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Snakebites

Causes in Alphabetical Order

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Stasi R (2012). "How to approach thrombocytopenia". Hematology Am Soc Hematol Educ Program. 2012: 191–7. doi:10.1182/asheducation-2012.1.191. PMID 23233580.
  2. ↑ 2.0 2.1 2.2 2.3 Greenberg EM, Kaled ES (2013). "Thrombocytopenia". Crit Care Nurs Clin North Am. 25 (4): 427–34, v. doi:10.1016/j.ccell.2013.08.003. PMID 24267279.
  3. ↑ Farid J, Gul N, Qureshi WU, Idris M (2012). "Clinical presentations in immune thrombocytopenic purpura". J Ayub Med Coll Abbottabad. 24 (2): 39–40. PMID 24397048.
  4. ↑ Nisha S, Amita D, Uma S, Tripathi AK, Pushplata S (2012). "Prevalence and characterization of thrombocytopenia in pregnancy in Indian women". Indian J Hematol Blood Transfus. 28 (2): 77–81. doi:10.1007/s12288-011-0107-x. PMC 3332269. PMID 23730013.
  5. ↑ Abdel Karim N, Haider S, Siegrist C, Ahmad N, Zarzour A, Ying J; et al. (2013). "Approach to management of thrombotic thrombocytopenic purpura at university of cincinnati". Adv Hematol. 2013: 195746. doi:10.1155/2013/195746. PMC 3876823. PMID 24396345.

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