Template:Metoprolol: Difference between revisions

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{| style="margin: 0 0 3em 3em; border: 1px solid #696969; float: right; width:20em" cellpadding="0" cellspacing="0";
{{Drugbox
! style="padding: 0 5px; font-size: 100%; background:#F8F8FF" align=center | '''''[[Metoprolol|{{fontcolor|#6C7B8B|Metoprolol}}]]'''''
| verifiedrevid = 459444186
|-
| IUPAC_name = (''RS'')-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol
! style="padding: 0 5px; font-size: 85%; background:#F5F5F5" align=left | Lopressor<sup>®</sup>, Toprol XL<sup>®</sup> FDA Package Insert
| image = 2000px-Metoprolol structure.svg.png
|-
| drug_name = Metoprolol
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol indications and usage|Indications and Usage]]
 
|-
<!--Clinical data-->
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol dosage and administration|Dosage and Administration]]
| tradename = Lopressor, Toprol-xl
|-
| Drugs.com = {{drugs.com|monograph|metoprolol-succinate}}
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol dosage forms and strengths|Dosage Forms and Strengths]]
| MedlinePlus = a682864
|-
| licence_US = Metoprolol
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol contraindications|Contraindications]]
| pregnancy_AU = C
|-
| pregnancy_US = C
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol warnings and precautions|Warnings and Precautions]]
| legal_status = Rx-only
|-
| routes_of_administration = Oral, [[Intravenous|IV]]
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol adverse reactions|Adverse Reactions]]
 
|-
<!--Pharmacokinetic data-->
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol drug interactions|Drug Interactions]]
| bioavailability = 12%
|-
| metabolism = [[Liver|Hepatic]] via [[CYP2D6]], [[CYP3A4]]
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol use in specific populations|Use in Specific Populations]]
| elimination_half-life = 3-7 hours
|-
| excretion = [[Kidney|Renal]]
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol overdosage|Overdosage]]
 
|-
<!--Identifiers-->
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol description|Description]]
| CAS_number_Ref = {{cascite|correct|??}}
|-
| CAS_number = 51384-51-1
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol clinical pharmacology|Clinical Pharmacology]]
| ATC_prefix = C07
|-
| ATC_suffix = AB02
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol nonclinical toxicology|Nonclinical Toxicology]]
| PubChem = 4171
|-
| IUPHAR_ligand = 553
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol clinical studies|Clinical Studies]]
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
|-
| DrugBank = DB00264
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol how supplied storage and handling|How Supplied/Storage and Handling]]
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
|-
| ChemSpiderID = 4027
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol patient counseling information|Patient Counseling Information]]
| UNII_Ref = {{fdacite|correct|FDA}}
|-
| UNII = GEB06NHM23
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol labels and packages|Labels and Packages]]
| KEGG_Ref = {{keggcite|correct|kegg}}
|-
| KEGG = D02358
|}
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 6904
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 13
 
<!--Chemical data-->
| C=15 | H=25 | N=1 | O=3
| molecular_weight = 267.364&nbsp;[[gram|g]]/[[Mole (unit)|mol]]
| smiles = O(c1ccc(cc1)CCOC)CC(O)CNC(C)C
| InChI = 1/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
| InChIKey = IUBSYMUCCVWXPE-UHFFFAOYAN
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = IUBSYMUCCVWXPE-UHFFFAOYSA-N
| melting_point = 120
}}

Latest revision as of 15:36, 21 March 2014

Metoprolol
Clinical data
Trade namesLopressor, Toprol-xl
AHFS/Drugs.comMonograph
MedlinePlusa682864
[[Regulation of therapeutic goods |Template:Engvar data]]
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Routes of
administration		Oral, IV
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability12%
MetabolismHepatic via CYP2D6, CYP3A4
Elimination half-life3-7 hours
ExcretionRenal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC15H25NO3
Molar mass267.364 g/mol
3D model (JSmol)
Melting point120 °C (248 °F)
  (verify)
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