Lopressor/use in specific populations: Difference between revisions

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__NOTOC__
#REDIRECT [[Metoprolol tartrate#Use in Specific Populations]]
{{Metoprolol}}
{{CMG}}; {{AE}} {{AZ}}
 
==Pharmacokinetics Special populations==
====Geriatric patients====
The geriatric population may show slightly higher plasma concentrations of metoprolol as a combined result of a decreased metabolism of the drug in elderly population and a decreased hepatic blood flow. However, this increase is not clinically significant or therapeutically relevant.
====Renal impairment====
The systemic availability and half-life of Lopressor in patients with renal failure do not differ to a clinically significant degree from those in normal subjects.
====Hepatic Impairment====
Since the drug is primarily eliminated by hepatic metabolism, hepatic impairment may impact the pharmacokinetics of metoprolol. The elimination half-life of metoprolol is considerably prolonged, depending on severity (up to 7.2 h).
 
==Uses in Special Population==
 
===Pediatric patients===
No pediatric studies have been performed. The safety and efficacy of Lopressor in pediatric patients have not been established.
===Renal impairment===
No dose adjustment of Lopressor is required in patients with renal impairment.
===Hepatic impairment===
Lopressor blood levels are likely to increase substantially in patients with hepatic impairment. Therefore, Lopressor should be initiated at low doses with cautious gradual dose titration according to clinical response.
===Geriatric patients (>65 years)===
In general, use a low initial starting dose in elderly patients given their greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = LOPRESSOR (METOPROLOL TARTRATE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bb05420c-fd24-4672-9f62-fdd313819287 | publisher =  | date =  | accessdate = }}</ref>
==References==
{{Reflist}}
 
{{FDA}}
 
[[Category:Drugs]]

Latest revision as of 03:51, 22 July 2014

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