DURACLON drug interactions: Difference between revisions
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==Drug Interactions== | ==Drug Interactions== | ||
Clonidine may potentiate the CNS-depressive effect of alcohol, barbiturates or other sedating drugs. Narcotic analgesics may potentiate the hypotensive effects of clonidine. [[Tricyclic anti-depressant]]s may antagonize the [[hypotensive]] effects of clonidine. The effects of [[tricyclic anti-depressant]]s on clonidine’s analgesic actions are not known. | |||
[[Beta-blocker]]s may exacerbate the hypertensive response seen with clonidine withdrawal. Also, due to the potential for additive effects such as [[bradycardia]] and [[AV block]], caution is warranted in patients receiving clonidine with agents known to affect sinus node function or AV nodal conduction, e.g., [[digitalis]], [[calcium channel blocker]]s, and [[beta-blocker]]s. | |||
There is one reported case of a patient with acute delirium associated with the simultaneous use of [[fluphenazine]] and oral clonidine. Symptoms resolved when clonidine was withdrawn and recurred when the patient was rechallenged with clonidine. | |||
Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including both sensory and motor blockade.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DURACLON (CLONIDINE HYDROCHLORIDE) INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8c126bb8-732a-4949-8754-2f50b5543638#i4i_clinical_pharmacology_id_a61d4026-7aae-4211-9bb5-332675db4e46 | publisher = | date = | accessdate = 6 February 2014 }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 16:53, 6 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
For patient information, click here.
Drug Interactions
Clonidine may potentiate the CNS-depressive effect of alcohol, barbiturates or other sedating drugs. Narcotic analgesics may potentiate the hypotensive effects of clonidine. Tricyclic anti-depressants may antagonize the hypotensive effects of clonidine. The effects of tricyclic anti-depressants on clonidine’s analgesic actions are not known.
Beta-blockers may exacerbate the hypertensive response seen with clonidine withdrawal. Also, due to the potential for additive effects such as bradycardia and AV block, caution is warranted in patients receiving clonidine with agents known to affect sinus node function or AV nodal conduction, e.g., digitalis, calcium channel blockers, and beta-blockers.
There is one reported case of a patient with acute delirium associated with the simultaneous use of fluphenazine and oral clonidine. Symptoms resolved when clonidine was withdrawn and recurred when the patient was rechallenged with clonidine.
Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including both sensory and motor blockade.[1]
References
- ↑ "DURACLON (CLONIDINE HYDROCHLORIDE) INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC]". Retrieved 6 February 2014.