Topiramate overdosage: Difference between revisions
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{{CMG}}; {{AE}} {{PB}} | {{CMG}}; {{AE}} {{PB}} | ||
'''''For patient information, click [[Topiramate (patient information)|here]]''''' | '''''For patient information about topiramate, click [[Topiramate (patient information)|here]].''''' | ||
== | ==Drug Abuse and Dependence== | ||
====Controlled Substance==== | |||
Topiramate is not a controlled substance. | |||
===Abuse=== | |||
The abuse and dependence potential of topiramate has not been evaluated in human studies. | |||
===Dependence=== | |||
Topiramate has not been systematically studied in animals or humans for its potential for tolerance or physical dependence. | |||
==Overdosage== | |||
Overdoses of topiramate have been reported. Signs and symptoms included convulsions, drowsiness, speech disturbance, blurred vision, [[diplopia]], mentation impaired, [[lethargy]], abnormal coordination, stupor, [[hypotension]], abdominal pain, agitation, [[dizziness]], and [[depression]]. The clinical consequences were not severe in most cases, but deaths have been reported after poly-drug overdoses involving topiramate. | |||
Topiramate overdose has resulted in severe metabolic acidosis [see Warnings and Precautions (5.3)]. | |||
A patient who ingested a dose between 96 and 110 g topiramate was admitted to a hospital with a coma lasting 20 to 24 hours followed by full recovery after 3 to 4 days. | |||
In acute topiramate overdose, if the ingestion is recent, the stomach should be emptied immediately by lavage or by induction of emesis. Activated charcoal has been shown to adsorb topiramate in vitro. Treatment should be appropriately supportive. [[Hemodialysis]] is an effective means of removing topiramate from the body. | |||
Symptoms of overdose may include but are not limited to: | |||
* [[Seizures]] | |||
* [[Dizziness]], [[drowsiness]], tiredness | |||
* [[Agitation]] | |||
* [[Depression]] | |||
* Speech problems | |||
* Blurred vision, double vision | |||
* Troubled thinking | |||
* Loss of coordination | |||
* Inability to respond to things around you | |||
* Loss of consciousness | |||
* Confusion and coma | |||
* [[Fainting]] | |||
* Upset stomach and stomach pain | |||
* Loss of appetite and vomiting | |||
* Excessive hunger | |||
* Shortness of breath; fast, shallow breathing | |||
* Pounding or irregular heartbeat | |||
* Muscle weakness | |||
* Bone pain | |||
A specific antidote is not available. Treatment is entirely symptomatic.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TOPIRAMATE (TOPIRAMATE ) TABLET, FILM COATED [AUROBINDO PHARMA LIMITED] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=32b48ea0-a215-43b8-83b4-a5435a686d68 | publisher = | date = | accessdate = 6 February 2014 }}</ref> | |||
==References== | ==References== | ||
{{Reflist | {{Reflist}} | ||
{{FDA}} | |||
{{Antimigraine preparations}} | {{Antimigraine preparations}} | ||
[[Category:Antimigraine drugs]] | |||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Latest revision as of 02:11, 9 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
For patient information about topiramate, click here.
Drug Abuse and Dependence
Controlled Substance
Topiramate is not a controlled substance.
Abuse
The abuse and dependence potential of topiramate has not been evaluated in human studies.
Dependence
Topiramate has not been systematically studied in animals or humans for its potential for tolerance or physical dependence.
Overdosage
Overdoses of topiramate have been reported. Signs and symptoms included convulsions, drowsiness, speech disturbance, blurred vision, diplopia, mentation impaired, lethargy, abnormal coordination, stupor, hypotension, abdominal pain, agitation, dizziness, and depression. The clinical consequences were not severe in most cases, but deaths have been reported after poly-drug overdoses involving topiramate.
Topiramate overdose has resulted in severe metabolic acidosis [see Warnings and Precautions (5.3)].
A patient who ingested a dose between 96 and 110 g topiramate was admitted to a hospital with a coma lasting 20 to 24 hours followed by full recovery after 3 to 4 days.
In acute topiramate overdose, if the ingestion is recent, the stomach should be emptied immediately by lavage or by induction of emesis. Activated charcoal has been shown to adsorb topiramate in vitro. Treatment should be appropriately supportive. Hemodialysis is an effective means of removing topiramate from the body.
Symptoms of overdose may include but are not limited to:
- Seizures
- Dizziness, drowsiness, tiredness
- Agitation
- Depression
- Speech problems
- Blurred vision, double vision
- Troubled thinking
- Loss of coordination
- Inability to respond to things around you
- Loss of consciousness
- Confusion and coma
- Fainting
- Upset stomach and stomach pain
- Loss of appetite and vomiting
- Excessive hunger
- Shortness of breath; fast, shallow breathing
- Pounding or irregular heartbeat
- Muscle weakness
- Bone pain
A specific antidote is not available. Treatment is entirely symptomatic.[1]
References
- ↑ "TOPIRAMATE (TOPIRAMATE ) TABLET, FILM COATED [AUROBINDO PHARMA LIMITED]". Retrieved 6 February 2014.
Adapted from the FDA Package Insert.