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{{familytree/start |summary=Opioid withdrawal treatment algorithm.}}
{{familytree/start}}
{{familytree | | | | | | | | | | A01 | | | | | | | | | | |A01='''Induction: (day 1)'''}}
{{familytree | | | | | | | | | | | | A01 |-| A02 |-| A03 | | | | |A01=<div style="float: left; text-align: left; padding:1em">'''Confirmed aortic dissection''' <br> ❑ Check whether dissection occurred in ascending aorta </div>|A02=Yes |A03=Consider surgical management}}
{{familytree | | | | | | | | | | |!| | | | | | | | | | |}}
{{familytree | | | | | | | | | | | | |!| | | | | | | | | | | | | |}}
{{familytree | | | | | | | | | | B01 | | | | | |B01=Identify the opioid's the patient has been using}}
{{familytree | | | | | | | | | | | | B01 | | | | | | | | | | | | |B01=No}}
{{familytree | | | | | | |,|-|-|-|^|-|-|-|.| | | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | | | | | | |!| | | | | | | | | | | | | |}}
{{familytree | | | | | | C01 | | | | | | C02 | | | | | | | |C01=Short acting opioids|C02=Long acting opioids}}
{{familytree | | | | | | | | | | | | C01 | | | | | | | | | | | | |C01=<div style="float: left; text-align: left; padding:1em">❑ Start Medical management </div>}}
{{familytree | | | | | | |!| | | | | | | |!| | | | | | | | |}}
{{familytree | | | | | | | | | | | | |!| | | | | | | | | | | | | |}}
{{familytree | | | | | | D01 | | | | | | D03 | | | | | | | | |D01=<div style="float: left; text-align: left"> ❑ Discontinue short acting opioids <br> ❑ Look for withdrawal symptoms (12-24 hours after last dose)</div>|D03=<div style="float: left; text-align: left"> ❑ Taper down long acting opioids<br>
{{familytree | | | | | | | | | | | | D01 | | | | | | | | | | | | |D01=<div style="float: left; text-align: left; padding:1em">❑ Check Vitals <br>
:❑ Methadone to ≤ 30 mg/day
:❑ Blood pressure in both arms <br>
:❑ LAAM to ≤ 40 mg/48 hours<br>
:Take the highest reading for treatment or goal therapy <br>
❑ Look for withdrawal symptoms:<br>
❑ Is patient hemodynamically stable ?</div> }}
:❑ For methadone: 24+ hours after last dose
{{familytree | | | | | | | | |,|-|-|-|^|-|-|-|-|-|-|-|.| | | | | |}}
:❑ For LAAM: 48+ hours after last dose</div>}}
{{familytree | | | | | | | | E01 | | | | | | | | | | E02 | | | | |E01=Yes |E02=No}}
{{familytree | | | | | | |)|-|-|-|v|-|-|-|(| | | | | | |}}
{{familytree | | | | | | | | |!| | | | | | | |,|-|-|-|^|-|-|-|.| |}}
{{familytree | | | | | | E01 | | E02 | | E03 | | | | | |E01=<div style="float: left; text-align: left">'''Withdrawal symptoms present:'''<br> ❑ Administer buprenorphine/naloxone 4/1 mg <br> ❑ Observe for 2+ hours </div> |E02=<div style="float: left; text-align: left"> '''Withdrawal symptoms absent:''' <br> ❑ Reevaluate the suitability for induction </div> |E03==<div style="float: left; text-align: left">'''Withdrawal symptoms present:'''<br> ❑ Administer buprenorphine 2 mg <BR> Observe 2+ hours</div>}}
{{familytree | | | | | | | | F01 | | | | | | F02 | | | | | | F03 |F01=<div style="float: left; text-align: left; padding:1em">❑ Control rate and pressure<br>
{{familytree | | | | | | |)|-|-|-|v|-|-|-|(| | | | | | |}}
: I.V [[Beta blockers]] or [[labetalol]]
{{familytree | | | | | | F01 | | F02 | | F03 | | | | | |F01=<div style="float: left; text-align: left">'''Withdrawal symptoms not relieved:''' <br> ❑ Repeat buprenorphine 4mg (up to maximum of 8mg/24 hours <br> ❑ Naloxone 1 mg (up to maximum of 2 mg/24 hours)</div>|F02=<div style="float: left; text-align: left">'''Withdrawal symptoms relieved:'''<br> ❑ Day 1 dose established <BR> ❑ Send home patient <BR> ❑ Patient should return on day 2 for forward induction</div> |F03==<div style="float: left; text-align: left">'''Withdrawal symptoms not relieved:''' <br> ❑ Repeat<br>
: Substitute [[diltiazem]] and [[verapamil]]<br> If [[betablockers]] are contraindicated
:❑ Buprenorphine 2mg (up to maximum of 8mg/24 hours)</div> }}
----
{{familytree | | | | | | |`|-|-|-|v|-|-|-|'| | | | | | | | | |}}
❑ Goal Heart rate should be 60 beats per minute
{{familytree | | | | | | |,|-|-|-|^|-|-|-|.| | | | | | | | | |}}
----
{{familytree | | | | | | G01 | | | | | | G02 | | | | | | | | | |G01=<div style="float: left; text-align: left">'''Withdrawal symptoms relieved:'''<br>❑ Day 1 dose established<BR>❑ Send home patient<BR>❑ Patient should return on day 2 for forward induction</div>|G02=<div style="float: left; text-align: left">'''Withdrawal symptoms not relieved:'''<br>Manage withdrawal symptoms symptomatically<br>
❑ Pain control<br>
:❑ [[Clonidine]] 0.2 mg every 4 hours, tapered after day 3,<ref name="O'Connor-1995">{{Cite journal  | last1 = O'Connor | first1 = PG. | last2 = Waugh | first2 = ME. | last3 = Carroll | first3 = KM. | last4 = Rounsaville | first4 = BJ. | last5 = Diagkogiannis | first5 = IA. | last6 = Schottenfeld | first6 = RS. | title = Primary care-based ambulatory opioid detoxification: the results of a clinical trial. | journal = J Gen Intern Med | volume = 10 | issue = 5 | pages = 255-60 | month = May | year = 1995 | doi =  | PMID = 7616334 }}</ref><br>'''or'''<br>
: ❑ Use [[Opiates]]</div> |F02=<div style="float: left; text-align: left; padding:1em"> '''Type A dissection'''
:❑ [[Lofexidine]] 0.2 mg BD daily, titrated to 1.2 mg BD daily <ref name="Strang-1999">{{Cite journal  | last1 = Strang | first1 = J. | last2 = Bearn | first2 = J. | last3 = Gossop | first3 = M. | title = Lofexidine for opiate detoxification: review of recent randomised and open controlled trials. | journal = Am J Addict | volume = 8 | issue = 4 | pages = 337-48 | month =  | year = 1999 | doi = | PMID = 10598217 }}</ref><br>
----
:❑ Chlordiazepoxide as needed<BR>
❑ Expedited surgical consultation and consider surgery (Urgent)<br>
❑ Return next day for repeat induction attempt</div>}}
Maintain Euvolemic status<br>
{{familytree | | | | | | |!| | | | | | | | | | | | | | | | | |}}
: Intravenous fluid replacement<br>
{{familytree | | | | | | H01 | | | | | | | | | | | | | | | | | |H01='''Induction-day 2 forward'''}}
:❑ Maintain [[mean arterial pressure|mean arterial pressure (MAP)]] of 70 mm of hg<br>
{{familytree | | | | | | |)|-|-|-|-|-|-| I01 | | | | | | | | |I01=<div style="float: left; text-align: left">'''On return withdrawal symptoms absent:'''<br>❑ Administer a daily dose established equal to total buprenorphine & naloxone administered on previous day </div>}}
❑ Rule out complications using imaging study<br>
{{familytree | | | | | | J01 | | | | | | | | | | | | | | | | | |J01=<div style="float: left; text-align: left">'''On return withdrawal symptoms present:'''<br>❑ Administer dose equal to<br>Total amount of buprenorphine & naloxone administered on previous day<br>'''+'''<br>4mg of buprenorphine (up to maximum of 12mg on day 2)<br>&<br>1mg of naloxone (up to maximum of 3mg on day 2)<br>❑ Observe 2+ hours</div> }}
: ❑ [[Cardiac tamponade|Pericardial tamponade]]
{{familytree | | | | | | |)|-|-|-|-|-|-| K01 | | | | | | | | |K01=<div style="float: left; text-align: left">'''Withdrawal symptoms relieved:'''<br>❑ Daily buprenorphine & naloxone dose established </div>}}
: ❑ [[Aortic rupture|Rupture of aorta]]<br>
{{familytree | | | | | | L01 | | | | | | | | | | | | | | | | | |L01=<div style="float: left; text-align: left">'''Withdrawal symptoms not relieved:'''<br>❑ Administer buprenorphine 4 mg (up to maximum of 16mg on day 2) & naloxone 1 mg (up to maximum of 4 mg on day 2)</div> }}
: [[Aortic insufficiency]]</div>|F03=<div style="float: left; text-align: left; padding:1em">❑ Type B dissection
{{familytree | | | | | | |)|-|-|-|-|-|-| M01 | | | | | | | | |M01=<div style="float: left; text-align: left">'''Withdrawal symptoms relieved:'''<br>❑ Daily buprenorphine & naloxone dose established </div>}}
----
{{familytree | | | | | | N01 | | | | | | | | | | | | | | | | | |N01=<div style="float: left; text-align: left">'''Withdrawal symptoms not relieved:'''<br>Manage withdrawal symptoms symptomatically<br>
❑ Intravenous fluid replacement<br>
:❑ [[Clonidine]] 0.2 mg every 4 hours, tapered after day 3,<ref name="O'Connor-1995">{{Cite journal  | last1 = O'Connor | first1 = PG. | last2 = Waugh | first2 = ME. | last3 = Carroll | first3 = KM. | last4 = Rounsaville | first4 = BJ. | last5 = Diagkogiannis | first5 = IA. | last6 = Schottenfeld | first6 = RS. | title = Primary care-based ambulatory opioid detoxification: the results of a clinical trial. | journal = J Gen Intern Med | volume = 10 | issue = 5 | pages = 255-60 | month = May | year = 1995 | doi =  | PMID = 7616334 }}</ref><br>'''or'''<br>
: ❑ Maintain [[mean arterial pressure|mean arterial pressure (MAP)]] of 70 mm of hg<br>
:❑ [[Lofexidine]] 0.2 mg BD daily, titrated to 1.2 mg BD daily <ref name="Strang-1999">{{Cite journal  | last1 = Strang | first1 = J. | last2 = Bearn | first2 = J. | last3 = Gossop | first3 = M. | title = Lofexidine for opiate detoxification: review of recent randomised and open controlled trials. | journal = Am J Addict | volume = 8 | issue = 4 | pages = 337-48 | month =  | year = 1999 | doi =  | PMID = 10598217 }}</ref><br>
❑ Start vasopressor if still hypotensive
:❑ Chlordiazepoxide as needed<BR>
----
❑ On subsequent induction days, if the patient returns experiencing withdrawal symptoms, continue increasing dose (up to a maximum of buprenorphine 32 mg/day & naloxone 8 mg/day</div> }}
❑ Find out etiology of hypertension
:❑ Imaging to find out contained rupture
:❑ Perform [[Echocardiography|Transthoracic echocardiogram (TTE)]] to assess cardiac function
----
❑ Consider surgical evaluation</div> }}
{{familytree | | | | | | | | |!| | | | | | | |!| | | | | | | |!| |}}
{{familytree | | | | | | | | |!| | | | | | | G01 | | | | | | |!| |G01=<div style="float: left; text-align: left; padding:1em">❑ Can the cause of hypotension respond to surgical management</div>}}
{{familytree | | | | | | | | |!| | | |,|-|-|-|^|-|-|-|.| | | |!| |}}
{{familytree | | | | | | | | H01 |-| H02 | | | | | | H03 |-| H04 |H01=<div style="float: left; text-align: left; padding:1em">❑ Monitor vitals closely
: ❑ Maintain systolic BP <120 mm of Hg</div> |H02=No |H03=Yes |H04=Consider surgical management}}
{{familytree | | | | |,|-|-|-|^|-|-|-|.| | | | | | | | | | | | | |}}
{{familytree | | | | I01 | | | | | | I02 | | | | | | | | | | | | |I01=Yes |I02=No}}
{{familytree | | | | |!| | | | | | | |!| | | | | | | | | | | | | |}}
{{familytree | | | | |!| | | | | | | J01 |-|-|-|-|-| J02 | | | | |J01=<div style="float: left; text-align: left; padding:1em"> ❑ Check whether dissection involves ascending aorta</div> |J02=Yes}}
{{familytree | | | | |!| | | | | | | |!| | | | | | | |!| | | | | |}}
{{familytree | | | | |!| | | | | | | K01 | | | | | | |!| | | | | |K01=No}}
{{familytree | | | | |!| | | | | | | |!| | | | | | | |!| | | | | |}}
{{familytree | | | | |`|-|-| L01 |-|-|'| | | | | | | |!| | | | | |L01=<div style="float: left; text-align: left; padding:1em">❑ Control blood pressure
: ❑ Intravenous vasodilator</div>}}
{{familytree | | | | | | | | |!| | | | | | | | | | | |!| | | | | |}}
{{familytree | | | | | | | | M01 | | | | | | | | | | |!| | | | | |M01=<div style="float: left; text-align: left; padding:1em">❑ Monitor vitals closely
: ❑ Maintain systolic BP <120 mm of Hg</div>}}
{{familytree | | | | | | | | |!| | | | | | | | | | | |!| | | | | |}}
{{familytree | | | | | | | | N01 |-| N02 |-| N03 |-|-|'| | | | | |N01=<div style="float: left; text-align: left; padding:1em">❑ Check for any complications which might require surgery
----
: ❑ Malperfusion
: ❑ Progressing dissection
: ❑ Expansion of aortic aneurysm
: ❑ [[Hypertension causes|Uncontrolled or refractory hypertension]] </div> |N02=Yes|N03=<div style="float: left; text-align: left; padding:1em">❑ Consider surgical management</div>}}
{{familytree | | | | | | | | |!| | | | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | | O01 | | | | | | | | | | | | | | | | |O01=No}}
{{familytree | | | | | | | | |!| | | | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | | P01 | | | | | | | | | | | | | | | | |P01=<div style="float: left; text-align: left; padding:1em">❑ Switch to oral medications <br>
:❑ [[Betablockers]]
:❑ Antihypertensive regimen
----
❑ Follow up in the outpatient</div>}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | |}}
 
==First Initial Rapid Evaluation of Suspected Aortic Dissection==
Shown below is an algorithm for the First Initial Rapid Evaluation (FIRE) of Aortic dissection.
{{familytree/start}}
{{familytree | | | | | | | | | | A01 | | | | | | | | | | |A01=❑ Identify cardinal signs and symptoms that increase the pretest probability of acute aortic rupture }}
{{familytree | | | | | | | | | | |!| | | | | | | | | | | | }}
{{familytree | | | | | | | | | | B01 | | | | | | | | | | |B01=<div style="text-align: left">❑ Sudden onset chest pain (tearing/ripping/sharp or stabbing)<br>
❑ Asymmetric blood pressure in extremities<br>
❑ Shock <br>
❑ Pulse deficit <br>
❑ Evolving aortic regurgitation murmur </div>}}
{{familytree | | | | | | |,|-|-|-|^|-|-|-|.| | | | | | | | }}
{{familytree | | | | | | C01 | | | | | | C02 | | | | | | |C01=<div style=" background: #F60A0A"> {{fontcolor|#F8F8FF|Unstable patient}} </div>|C02=Stable patient }}
{{familytree | | | | | | |!| | | | | | | |!| | | | | | | | }}
{{familytree | | | | | | D01 | | | | | | D02 | | | | | | |D01=<div style="background: #F60A0A; text-align: left"> {{fontcolor|#F8F8FF|❑ Order urgent TTE <br> ❑ Look for the following high risk features: <br>
:❑ Pericardial effusion <br>
:❑ Regional wall motion abnormality (RWMA) <br>
:❑ Dilated root <br>
:❑ Aortic regurgitation (AR)}} </div>  |D02=[[Aortic dissection resident survival guide#Diagnosis|Continue with diagnostic approach]] }}
{{familytree | | | | | | |!| | | | | | | | | | | | | | | | }}
{{familytree | | | | | | |!| | | | | | | | | | | | | | | | }}
{{familytree | | | | | | O01 | | | | | | | | | | | | | | |O01=<div style="float: left; text-align: left">'''Stabilization phase (1-2 months):''' <br> Transition when patient has:
{{familytree | | | | | | E01 | | | | | | | | | | | | | | |E01=<div style=" background: #F60A0A; text-align: left"> {{fontcolor|#F8F8FF|Aortic dissection confirmed
:No withdrawal symptoms <br>
Transfer to Cardio-thoracic unit
:Minimal or no side effects <br>
Perform TEE in CCU or cardiac OR }} </div>}}
:❑ No uncontrollable craving for opioid agonists <br>
{{familytree | | | | | | |!| | | | | | | | | | | | | | | | }}
❑ Begin with buprenorphine/naloxone combination, increasing dose by 2/0.5-4/1 mg per week till stabilization is achieved, most stabilizing at 16/4-24/6 mg <br> ❑ As patient stabilizes, transition to alternate day or every third day regimen by doubling and tripling daily doses respectively </div> }}
{{familytree | | | | | | F01 | | | | | | | | | | | | | | |F01=<div style=" background: #F60A0A"> {{fontcolor|#F8F8FF|Proceed to surgery}} </div> }}
{{familytree | | | | | | |!| | | | | | | | | | | }}
{{familytree | | | | | | P01 | | | | | | | | | |P01=<div style="float: left; text-align: left">'''Maintenance phase:''' <br>
Maintain at same dose as daily stabilization dose <br> ❑ Decide total treatment duration based on: <br>
:❑ Stable housing & income <br>
:❑ Patients motivation, doctors comfort in tapering <br>
:❑ Presence of psychosocial support
:❑ Absence of legal support
:❑ Other drugs & alcohol abuse </div> }}
{{familytree/end}}
{{familytree/end}}
Look for the following: Intimal flap and tear <br> Intimal entry <br> Mobile linear flap in short axis view <br> Small central true lumen communicating with false lumen

Latest revision as of 22:25, 1 April 2014

First Initial Rapid Evaluation of Suspected Aortic Dissection

Shown below is an algorithm for the First Initial Rapid Evaluation (FIRE) of Aortic dissection.

 
 
 
 
 
 
 
 
 
 
 
Confirmed aortic dissection
❑ Check whether dissection occurred in ascending aorta
 
Yes
 
Consider surgical management
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
No
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Start Medical management
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Check Vitals
❑ Blood pressure in both arms
❑ Take the highest reading for treatment or goal therapy
❑ Is patient hemodynamically stable ?
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Yes
 
 
 
 
 
 
 
 
 
No
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Control rate and pressure
❑ I.V Beta blockers or labetalol
❑ Substitute diltiazem and verapamil
If betablockers are contraindicated

❑ Goal Heart rate should be 60 beats per minute


❑ Pain control

❑ Use Opiates
 
 
 
 
 
Type A dissection

❑ Expedited surgical consultation and consider surgery (Urgent)
❑ Maintain Euvolemic status

❑ Intravenous fluid replacement
❑ Maintain mean arterial pressure (MAP) of 70 mm of hg

❑ Rule out complications using imaging study

Pericardial tamponade
Rupture of aorta
Aortic insufficiency
 
 
 
 
 
❑ Type B dissection

❑ Intravenous fluid replacement

❑ Maintain mean arterial pressure (MAP) of 70 mm of hg

❑ Start vasopressor if still hypotensive


❑ Find out etiology of hypertension

❑ Imaging to find out contained rupture
❑ Perform Transthoracic echocardiogram (TTE) to assess cardiac function

❑ Consider surgical evaluation
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Can the cause of hypotension respond to surgical management
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Monitor vitals closely
❑ Maintain systolic BP <120 mm of Hg
 
No
 
 
 
 
 
Yes
 
Consider surgical management
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Yes
 
 
 
 
 
No
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Check whether dissection involves ascending aorta
 
 
 
 
 
Yes
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
No
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Control blood pressure
❑ Intravenous vasodilator
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Monitor vitals closely
❑ Maintain systolic BP <120 mm of Hg
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Check for any complications which might require surgery
❑ Malperfusion
❑ Progressing dissection
❑ Expansion of aortic aneurysm
Uncontrolled or refractory hypertension
 
Yes
 
❑ Consider surgical management
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
No
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Switch to oral medications
Betablockers
❑ Antihypertensive regimen

❑ Follow up in the outpatient
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Identify cardinal signs and symptoms that increase the pretest probability of acute aortic rupture
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Sudden onset chest pain (tearing/ripping/sharp or stabbing)

❑ Asymmetric blood pressure in extremities
❑ Shock
❑ Pulse deficit

❑ Evolving aortic regurgitation murmur
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Unstable patient
 
 
 
 
 
Stable patient
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Order urgent TTE
❑ Look for the following high risk features:
❑ Pericardial effusion
❑ Regional wall motion abnormality (RWMA)
❑ Dilated root
❑ Aortic regurgitation (AR)
 
 
 
 
 
Continue with diagnostic approach
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Aortic dissection confirmed

❑ Transfer to Cardio-thoracic unit

❑ Perform TEE in CCU or cardiac OR
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
❑ Proceed to surgery
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Look for the following: Intimal flap and tear
Intimal entry
Mobile linear flap in short axis view
Small central true lumen communicating with false lumen