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| __NOTOC__
| | #REDIRECT [[Cholestyramine]] |
| {{Cholestyramine}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Adverse Reactions==
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| The most common adverse reaction is [[constipation]]. When used as a cholesterol-lowering agent, predisposing factors for most complaints of [[constipation]] are high dose and increased age (more than 60 years old). Most instances of [[constipation]] are mild, transient, and controlled with conventional therapy. Some patients require a temporary decrease in dosage or discontinuation of therapy.
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| '''Less Frequent Adverse Reactions''': Abdominal discomfort and/or pain, [[flatulence]], [[nausea]], [[vomiting]], [[diarrhea]], [[dyspepsia]], [[eructation]], [[anorexia]], [[steatorrhea]], bleeding tendencies due to [[hypoprothrombinemia]] (Vitamin K deficiency) as well as Vitamin A (one case of night blindness reported) and D deficiencies, [[hyperchloremic]] acidosis in children, [[osteoporosis]], [[rash]] and [[irritation]] of the skin, tongue and perianal area. Rare reports of intestinal obstruction, including two deaths, have been reported in pediatric patients.
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| Occasional calcified material has been observed in the biliary tree, including calcification of the gallbladder, in patients to whom cholestyramine resin has been given. However, this may be a manifestation of the liver disease and not drug-related.
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| One patient experienced biliary colic on each of three occasions on which he took a cholestyramine for oral suspension product. One patient diagnosed as acute abdominal symptom complex was found to have a “pasty mass” in the transverse colon on x-ray.
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| Other events (not necessarily drug-related) reported in patients taking cholestyramine resin include:
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| Gastrointestinal—GI-rectal bleeding, black stools, hemorrhoidal bleeding, bleeding from known duodenal ulcer, [[dysphagia]], [[hiccups]], ulcer attack, sour taste, [[pancreatitis]], rectal pain, [[diverticulitis]].
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| *Laboratory test changes—Liver function abnormalities.
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| *Hematologic—Prolonged prothrombin time, [[ecchymosis]], [[anemia]].
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| *Hypersensitivity—[[Urticaria]], [[asthma]], [[wheezing]], shortness of breath.
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| *Musculoskeletal—Backache, muscle and joint pains, [[arthritis]].
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| *Neurologic—Headache, [[anxiety]], [[vertigo]], [[dizziness]], [[fatigue]], [[tinnitus]], [[syncope]], drowsiness, femoral nerve pain, [[paresthesia]].
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| *Eye—[[Uveitis]].
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| *Renal—[[Hematuria]], [[dysuria]], burnt odor to urine, [[diuresis]].
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| *Miscellaneous—Weight loss, weight gain, increased [[libido]], swollen glands, [[edema]], dental bleeding, dental caries, erosion of tooth enamel, tooth discoloration.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = PREVALITE (CHOLESTYRAMINE) POWDER, FOR SUSPENSION [UPSHER-SMITH LABORATORIES INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=dd434ef8-8af3-434c-a0a0-9a0b18459ba0 | publisher = | date = | accessdate = 10 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| {{Lipid modifying agents}}
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| [[Category:Hepatology]]
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| [[Category:Bile acid sequestrants]]
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| [[Category:Cardiovasuclar Drugs]]
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| [[Category:Drugs]]
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