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| __NOTOC__
| | #REDIRECT [[Benazepril#Adult Indications and Dosage]] |
| {{Benazepril}}
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| {{CMG}}; {{AE}} {{AM}}
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| ==Dosage and Administration==
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| ====Hypertension====
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| ======Adults======
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| The recommended initial dose for patients not receiving a [[diuretic]] is 10 mg once a day. The usual maintenance dosage range is 20-40 mg per day administered as a single dose or in two equally divided doses. A dose of 80 mg gives an increased response, but experience with this dose is limited. The divided regimen was more effective in controlling trough (pre-dosing) blood pressure than the same dose given as a once-daily regimen. Dosage adjustment should be based on measurement of peak (2-6 hours after dosing) and trough responses. If a once-daily regimen does not give adequate trough response, an increase in dosage or divided administration should be considered. If blood pressure is not controlled with Lotensin alone, a [[diuretic]] can be added.
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| Total daily doses above 80 mg have not been evaluated.
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| Concomitant administration of Lotensin with [[potassium]] supplements, potassium salt substitutes, or potassium-sparing [[diuretic]]s can lead to increases of serum [[potassium]] (see PRECAUTIONS).
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| In patients who are currently being treated with a [[diuretic]], symptomatic [[hypotension]] occasionally can occur following the initial dose of Lotensin. To reduce the likelihood of [[hypotension]], the [[diuretic]] should, if possible, be discontinued two to three days prior to beginning therapy with Lotensin (see WARNINGS). Then, if [[blood pressure]] is not controlled with Lotensin alone, [[diuretic]] therapy should be resumed.
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| If the [[diuretic]] cannot be discontinued, an initial dose of 5 mg Lotensin should be used to avoid excessive [[hypotension]].
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| ======Pediatrics======
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| In children, doses of Lotensin between 0.1 and 0.6 mg/kg once daily have been studied, and doses greater than 0.1 mg/kg were shown to reduce blood pressure (see Pharmacodynamics). Based on this, the recommended starting dose of Lotensin is 0.2 mg/kg once per day as monotherapy. Doses above 0.6 mg/kg (or in excess of 40 mg daily) have not been studied in pediatric patients.
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| For pediatric patients who cannot swallow tablets, or for whom the calculated dosage (mg/kg) does not correspond to the available tablet strengths for Lotensin, follow the suspension preparation instructions below to administer benazepril HCl as a suspension.
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| Treatment with Lotensin is not advised for children below the age of 6 years (see PRECAUTIONS, Pediatric Use) and in pediatric patients with glomerular filtration rate <30 mL, as there are insufficient data available to support a dosing recommendation in these groups.
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| ====For Hypertensive Patients with Renal Impairment====
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| For patients with a [[creatinine clearance]] <30 mL/min/1.73 m2 (serum [[creatinine]] >3 mg/dL), the recommended initial dose is 5 mg Lotensin once daily. Dosage may be titrated upward until blood pressure is controlled or to a maximum total daily dose of 40 mg (see WARNINGS).
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| ====Preparation of Suspension (for 150 mL of a 2 mg/mL suspension)====
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| Add 75 mL of Ora-Plus®* oral suspending vehicle to an amber polyethylene terephthalate (PET) bottle containing fifteen Lotensin 20 mg tablets, and shake for at least 2 minutes. Allow the suspension to stand for a minimum of 1 hour. After the standing time, shake the suspension for a minimum of 1 additional minute. Add 75 mL of Ora-Sweet®* oral syrup vehicle to the bottle and shake the suspension to disperse the ingredients. The suspension should be refrigerated at 2-8°C (36-46°F) and can be stored for up to 30 days in the PET bottle with a child-resistant screw-cap closure. Shake the suspension before each use.
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| *Ora-Plus® and Ora-Sweet® are registered trademarks of Paddock Laboratories, Inc. Ora-Plus® contains carrageenan, citric acid, methylparaben, microcrystalline cellulose, carboxymethylcellulose sodium, potassium sorbate, simethicone, sodium phosphate monobasic, xanthan gum, and water. Ora-Sweet® contains citric acid, berry citrus flavorant, glycerin, methylparaben, potassium sorbate, sodium phosphate monobasic, sorbitol, sucrose, and water.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LOTENSIN (BENAZEPRIL HYDROCHLORIDE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4d954024-a191-46e3-ba71-2a7d5b0c65d5#nlm34067-9 | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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