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| __NOTOC__
| | #REDIRECT [[Benazepril#Adverse Reactions]] |
| {{Benazepril}}
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| {{CMG}} ; {{AE}} {{AM}}
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| ==Adverse Reactions==
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| Lotensin has been evaluated for safety in over 6000 patients with [[hypertension]]; over 700 of these patients were treated for at least one year. The overall incidence of reported adverse events was comparable in Lotensin and placebo patients.
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| The reported side effects were generally mild and transient, and there was no relation between side effects and age, duration of therapy, or total dosage within the range of 2 to 80 mg. Discontinuation of therapy because of a side effect was required in approximately 5% of U.S. patients treated with Lotensin and in 3% of patients treated with placebo.
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| The most common reasons for discontinuation were [[headache]] (0.6%) and [[cough]] (0.5%) (see PRECAUTIONS, Cough).
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| The side effects considered possibly or probably related to study drug that occurred in U.S. placebo-controlled trials in more than 1% of patients treated with Lotensin are shown below.
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| {|
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| | [[File:Los001.png|800px|thumb]]
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| Other adverse experiences reported in controlled clinical trials (in less than 1% of benazepril patients or with less than 1% difference in incidence between benazepril or placebo treatment), and rarer events seen in post-marketing experience, include the following (in some, a causal relationship to drug use is uncertain):
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| '''Dermatologic''': [[Stevens-Johnson syndrome]], [[pemphigus]], [[apparent hypersensitivity reactions]] (manifested by [[dermatitis]], [[pruritus]], or [[rash]]), [[photosensitivity]], and [[flushing]].
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| '''Gastrointestinal''': [[Nausea]], [[pancreatitis]], [[constipation]], [[gastritis]], [[vomiting]], and [[melena]].
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| '''Hematologic''': [[Thrombocytopenia]] and [[hemolytic anemia]].
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| Neurologic and Psychiatric: [[Anxiety]], decreased libido, [[hypertonia]], [[insomnia]], [[nervousness]], and [[paresthesia]].
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| Other: Fatigue, [[asthma]], [[bronchitis]], [[dyspnea]], [[sinusitis]], [[urinary tract infection]], frequent urination, infection, [[arthritis]], [[impotence]], [[alopecia]], [[arthralgia]],[[ myalgia]], [[asthenia]], sweating.
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| Another potentially important adverse experience, [[eosinophilic pneumonitis]], has been attributed to other [[ACE inhibitors]].
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| Pediatric Patients: The adverse experience profile for pediatric patients appears to be similar to that seen in adult patients.
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| ====Clinical Laboratory Test Findings====
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| Hemoglobin: Decreases in [[hemoglobin]] (a low value and a decrease of 5 g/dL) were rare, occurring in only 1 of 2,014 patients receiving Lotensin alone and in 1 of 1,357 patients receiving Lotensin plus a diuretic. No U.S. patients discontinued treatment because of decreases in hemoglobin.
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| Other (causal relationships unknown): Elevations of [[uric acid]], blood glucose, [[serum bilirubi]]n, and liver enzymes (see WARNINGS) have been reported, as have scattered incidents of [[hyponatremia]], electrocardiographic changes, , [[eosinophilia]], and [[proteinuria]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LOTENSIN (BENAZEPRIL HYDROCHLORIDE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4d954024-a191-46e3-ba71-2a7d5b0c65d5#nlm34067-9 | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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